Chiara Gamberi,Oona Johnstone,Paul Lasko
Chiara Gamberi
RNA binding proteins are fundamental mediators of gene expression. The use of the model organism Drosophila has helped to elucidate both tissue-specific and ubiquitous functions of RNA binding proteins. These proteins mediate all aspects of...
Esther P Haber,Joaquim Procópio,Carla R O Carvalho et al.
Esther P Haber et al.
Insulin resistance states as found in type 2 diabetes and obesity are frequently associated with hyperlipidemia. Both stimulatory and detrimental effects of free fatty acids (FFA) on pancreatic beta cells have long been recognized. Acute ex...
Christiane Gebhardt,Renate Schmidt,Katharina Schneider
Christiane Gebhardt
Plants are the basis for the survival of all "higher" organisms on Earth. Development of molecular genetics tools has allowed analysis of the structure, evolution, and function of whole plant genomes, rather than individual genes. DNA-based...
Dimitri A Kramerov,Nikita S Vassetzky
Dimitri A Kramerov
Short retroposons (SINEs) are repetitive elements amplified in the genome via an RNA intermediate, using the enzymatic machinery of autonomous retroposons (LINEs). SINEs are widely distributed in eukaryotes; for instance, all tested mammali...
Hypothalamic tanycytes: a key component of brain-endocrine interaction [0.03%]
下丘脑原绒细胞：大脑内分泌相互作用的关键因素
Esteban M Rodríguez,Juan L Blázquez,Francisco E Pastor et al.
Esteban M Rodríguez et al.
Tanycytes are bipolar cells bridging the cerebrospinal fluid (CSF) to the portal capillaries and may link the CSF to neuroendocrine events. During the perinatal period a subpopulation of radial glial cells differentiates into tanycytes, a c...
Sally P Wheatley,Iain A McNeish
Sally P Wheatley
Survivin is a fascinating little protein that acts as a component of the chromosomal passenger complex, which is essential for cell division, and as an inhibitor of apoptosis. With dual roles in promoting cell proliferation and preventing a...
Takahisa Hayashi,Kouki Yoshida,Yong Woo Park et al.
Takahisa Hayashi et al.
Many bacterial genomes contain a cellulose synthase operon together with a cellulase gene, indicating that cellulase is required for cellulose biosynthesis. In higher plants, there is evidence that cell growth is enhanced by the overexpress...
Howard J Worman,Jean-Claude Courvalin
Howard J Worman
The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases. While t...
Atsuo Ogura,Narumi Ogonuki,Hiromi Miki et al.
Atsuo Ogura et al.
Microinsemination has been widely used in basic reproductive research and in human-assisted reproductive technology for treating infertility. Historically, microinsemination in mammals started with research on the golden hamster; since then...
Maria Fällman,Anna Gustavsson
Maria Fällman
Upon host-cell contact, human pathogenic Yersinia species inject Yop virulence effectors into the host through a Type III secretion-and-translocation system. These virulence effectors cause a block in phagocytosis (YopE, YopT, YpkA, and Yop...