Michael A Rogers,Lutz Langbein,Silke Praetzel-Wunder et al.
Michael A Rogers et al.
Elucidation of the genes encoding structural proteins of the human hair follicle has advanced rapidly during the last decade, complementing nearly three previous decades of research on this subject in other species. Primary among these adva...
Cell and molecular biology of the exosome: how to make or break an RNA [0.03%]
细胞和分子生物学中的外泌体：如何制造或降解RNA
Geurt Schilders,Erwin van Dijk,Reinout Raijmakers et al.
Geurt Schilders et al.
The identification and characterization of the exosome complex has shown that the exosome is a complex of 3' --> 5' exoribonucleases that plays a key role in the processing and degradation of a wide variety of RNA substrates. Advances in th...
Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model [0.03%]
克服癌细胞凋亡耐受性的当前策略——以黑色素瘤为例
Peter Hersey,L Zhuang,X D Zhang
Peter Hersey
Most anticancer agents mediate their effects through common pathways which induce apoptosis or in some cases necrosis of cancer cells. The apoptotic pathways are regulated by Bcl-2 family proteins, which include both pro- and anti-apoptotic...
Matthew B Heintzelman
Matthew B Heintzelman
Gliding is a form of substrate-dependent cell locomotion exploited by a variety of disparate cell types. Cells may glide at rates well in excess of 1 microm/sec and do so without the gross distortion of cellular form typical of amoeboid cra...
Steven D Harris
Steven D Harris
The formation of highly polarized hyphae that grow by apical extension is a defining feature of the filamentous fungi. High-resolution microscopy and mathematical modeling have revealed the importance of the cytoskeleton and the Spitzenkorp...
Roles of PACAP-containing retinal ganglion cells in circadian timing [0.03%]
视网膜分泌PACAP的视ganglia细胞在生物钟中的作用
Jens Hannibal
Jens Hannibal
The brain's biological clock located in the suprachiasmatic nucleus (SCN) generates circadian rhythms in physiology and behavior. The clock-driven rhythms need daily adjustment (entrainment) to be synchronized with the astronomical day of 2...
María Angélica Santana,Fernando Esquivel-Guadarrama
María Angélica Santana
T cells are major components of the adaptive immune system. They can differentiate into two different populations of effector cells-type one and type two-and may also become tolerant. T cells respond to immune challenges by interacting with...
Georg Kraal,Reina Mebius
Georg Kraal
In the marginal zone of the spleen the bloodstream passes through an open system of reticular cells and fibers in which various myeloid and lymphoid cells are located. Macrophages in this region are well equipped to recognize pathogens and ...
Julie Lafond,Lucie Simoneau
Julie Lafond
The human placenta is a transitory organ, representing during pregnancy the unique connection between the mother and her fetus. The syncytiotrophoblast represents the specialized unit in the placenta that is directly involved in fetal nutri...
A model for lymphatic regeneration in tissue repair of the intestinal muscle coat [0.03%]
肠肌层组织修复淋巴管再生的模型研究
Hiroshi Shimoda,Seiji Kato
Hiroshi Shimoda
The gastrointestinal lymphatic system, which comprises a network of thin-walled vessels, is essential for the regulation of tissue fluid volume, immune function, and transport of fatty nutrients. The identification of specific lymphatic end...