Robert E Oswald
Robert E Oswald
Ionotropic glutamate receptors are the major excitatory neurotransmitters in mammalian brain but are found throughout the animal kingdom as well as in plants and bacteria. A great deal of progress in understanding the structure of these ess...
Roland K Strong,Benjamin J McFarland
Roland K Strong
NK cells are crucial components of the innate immune system, capable of directly eliminating infected or tumorigenic cells and regulating down-stream adaptive immune responses. Unlike T cells, where the key recognition event driving activat...
Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily [0.03%]
肿瘤坏死因子受体超家族的信号转导复合物组装
Hao Wu
Hao Wu
The tumor necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins that are structurally related in their extracellular domains and specifically activated by the corresponding superfamily of TNF...
The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors [0.03%]
生长激素-催乳素系统中激素和受体的生物学信号、调节和特异性的结构基础
Anthony A Kossiakoff
Anthony A Kossiakoff
The pituitary hormones growth hormone (GH), prolactin (PRL) and placental lactogen (PL), are members of an extensive cytokine superfamily of hormones and receptors that share many of the same general structure-function relationships in expr...
Shared cytokine signaling receptors: structural insights from the gp130 system [0.03%]
共享细胞因子信号受体：来自gp130系统的结构见解
Martin J Boulanger,K Christopher Garcia
Martin J Boulanger
The vast majority of cytokine signaling is mediated by "shared" receptors that form central signaling components of higher-order complexes incorporating ligand-specific receptors. These include the common gamma chain (gamma(c)), common beta...
William A Barton,Juha-Pekka Himanen,Alexander Antipenko et al.
William A Barton et al.
The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion [0.03%]
整合素及其配体的三维结构及其介导细胞粘附的构象调控机制研究
Timothy A Springer,Jia-Huai Wang
Timothy A Springer
Integrins are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, inte...
Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors [0.03%]
表皮生长因子（EGF/ErbB）受体家族的结构和功能
Daniel J Leahy
Daniel J Leahy
Adam Wood,Ali Shilatifard
Adam Wood