Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations [0.03%]
肽键到酯基的突变揭示反式反平行β-折叠中主链氢键对蛋白质折叠的动态与热力学的影响
Evan T Powers,Songpon Deechongkit,Jeffery W Kelly
Evan T Powers
The contribution of backbone-backbone hydrogen bonds (H-bonds) to protein folding energetics has been controversial. This is due, at least in part, to the inability to perturb backbone-backbone H-bonds by traditional methods of protein muta...
Potential functions for hydrogen bonds in protein structure prediction and design [0.03%]
氢键位势在蛋白质结构预测和设计中的应用
Alexandre V Morozov,Tanja Kortemme
Alexandre V Morozov
Hydrogen bonds are an important contributor to free energies of biological macromolecules and macromolecular complexes, and hence an accurate description of these interactions is important for progress in biomolecular modeling. A simple des...
Paul J Rothwell,Gabriel Waksman
Paul J Rothwell
DNA polymerases are molecular motors directing the synthesis of DNA from nucleotides. All polymerases have a common architectural framework consisting of three canonical subdomains termed the fingers, palm, and thumb subdomains. Kinetically...
Murray Stewart,Thomas M Roberts
Murray Stewart
Nematode sperm provide a simple and specialized system for studying the molecular mechanism of amoeboid cell motility. Locomotion is generated by the assembly dynamics of their cytoskeleton, which is based on the major sperm protein (MSP). ...
Rotary molecular motors [0.03%]
旋转分子马达
Stephan Wilkens
Stephan Wilkens
The F-, V-, and A-adenosine triphosphatases (ATPases) represent a family of evolutionarily related ion pumps found in every living cell. They either function to synthesize adenosine triphosphate (ATP) at the expense of an ion gradient or th...
A Marx,J Müller,E Mandelkow
A Marx
Microtubules are the intracellular tracks for two classes of motor proteins: kinesins and dyneins. During the past few years, the motor domain structures of several kinesins from different organisms have been determined by X-ray crystallogr...
Microtubules and maps [0.03%]
微管与地图
Linda A Amos,Daniel Schlieper
Linda A Amos
Microtubules are very dynamic polymers whose assembly and disassembly is determined by whether their heterodimeric tubulin subunits are in a straight or curved conformation. Curvature is introduced by bending at the interfaces between monom...
John M Squire,Carlo Knupp
John M Squire
Michael A Geeves,Kenneth C Holmes
Michael A Geeves