Monitoring of cerebral hemodynamics and oxygenation to detect delayed ischemic neurological deficit after aneurysmal subarachnoid hemorrhage [0.03%]
监测颅内血流动力学和氧合以检测动脉瘤性蛛网膜下腔出血后迟发型神经功能缺损
Martin Seule,Carl Muroi,Christopher Sikorski et al.
Martin Seule et al.
One of the major goals in the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH) is early detection and treatment of delayed ischemic neurologic deficits (DINDs) to prevent cerebral infarction and thus poor outcome or even...
Proposed mechanism of cerebral vasospasm: our hypothesis and current topics [0.03%]
脑血管痉挛的发病机制：我们的假设及当前的研究热点
Tomio Sasaki,Yuichiro Kikkawa
Tomio Sasaki
Increased vascular contractility plays an important role in the development of cerebral vasospasm following subarachnoid hemorrhage (SAH). Increased vascular contractility can be attributed to either endothelial dysfunction or increased con...
Prolonged intravenous infusion of sodium nitrite delivers nitric oxide (NO) in humans [0.03%]
长时间静脉输注亚硝酸钠可使人体内递送一氧化氮（NO）
Ryszard M Pluta
Ryszard M Pluta
In preclinical studies, infusion of sodium nitrite delivers nitric oxide (NO) as treatment of vasospasm after subarachnoid hemorrhage. We evaluated safety and toxicity of intravenous nitrite administration in healthy volunteers infused with...
Magnesium sulphate for aneurysmal subarachnoid hemorrhage: why, how, and current controversy [0.03%]
动脉瘤性蛛网膜下腔出血的硫酸镁治疗：为何、如何以及当前争议
George Kwok Chu Wong,Wai Sang Poon
George Kwok Chu Wong
The neuroprotective effect of magnesium sulphate infusion has been confirmed in experimental models. Pilot clinical trials using magnesium sulphate in patients with acute aneurysmal subarachnoid hemorrhage (SAH) have reported a trend toward...
Development of nicardipine prolonged-release implants after clipping for preventing cerebral vasospasm: from laboratory to clinical trial [0.03%]
尼卡地平缓释植入剂预防动脉瘤性蛛网膜下腔出血后脑血管痉挛的实验室及临床研究
Hidetoshi Kasuya
Hidetoshi Kasuya
We have developed a drug delivery system using a vasodilating drug that can be implanted intracranially at the time of surgery for aneurysm clipping, without systemic side effects or side effects associated with long-term intrathecal drug a...
Randomized Controlled Trial
Acta neurochirurgica. Supplement. 2013:115:41-4. DOI:10.1007/978-3-7091-1192-5_9 2013
Angiographic vasospasm versus cerebral infarction as outcome measures after aneurysmal subarachnoid hemorrhage [0.03%]
动脉瘤性蛛网膜下腔出血后的血管痉挛与脑梗死的结局差异研究
Nima Etminan,Mervyn D I Vergouwen,R Loch Macdonald
Nima Etminan
Background and purpose: Despite a significant reduction of angiographic vasospasm, the reduction of poor functional outcome in clinical trials on aneurysmal subarachnoid hemorrhage (SAH) remains challenging. While there i...
Randomised trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2) [0.03%]
有关蛛网膜下腔出血患者的随机试验（CONSCIOUS-2）：在进行外科手术夹闭的患者中，使用内皮素受体拮抗剂Clazosentan的效果
R Loch Macdonald,Randall T Higashida,Emanuela Keller et al.
R Loch Macdonald et al.
We report here results of a randomized, double-blind, placebo-controlled study ( http://www.ClinicalTrials.gov , NCT00558311) that investigated the effect of clazosentan (5 mg/h, n = 768) or placebo (n = 389) administered for up to 14 days ...
Protein biomarkers in patients with subarachnoid hemorrhage, vasospasm, and delayed ischemic neurological deficits [0.03%]
蛛网膜下腔出血、血管痉挛和迟发性神经功能缺损患者的蛋白质生物标志物
Paul A Nyquist,Honghui Wang,Anthony F Suffredini
Paul A Nyquist
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurological disease. It has many sequelae, including vasospasm and delayed ischemic neurological deficits (DINDs). We explored the blood proteome in patients with aSAH using transc...
Global cerebral atrophy after subarachnoid hemorrhage: a possible marker of acute brain injury and assessment of its impact on outcome [0.03%]
蛛网膜下腔出血后的全球脑萎缩：可能是急性脑损伤的标志并评估其对预后的影响
Alan K H Tam,Don Ilodigwe,Zeyu Li et al.
Alan K H Tam et al.
There is a correlation between poor neuropsychological outcome and focal regions of atrophy in patients with subarachnoid hemorrhage (SAH). No study has investigated the impact of global brain atrophy on outcome after SAH. In other neurolog...
Randomized Controlled Trial
Acta neurochirurgica. Supplement. 2013:115:17-21. DOI:10.1007/978-3-7091-1192-5_5 2013
Identifying patient report outcomes relevant to aneurysmal subarachnoid hemorrhage follow-up [0.03%]
确定用于动脉瘤性蛛网膜下腔出血随访的患者报告结果指标
Stuart Ross,Deepti Bhargava,Yahia Al-Tamimi et al.
Stuart Ross et al.
Patients recovered from subarachnoid hemorrhage can be assessed for neuropsychological dysfunction using postal questionnaires. We assessed 214 patients using various tests of memory, mood and strategic thinking. Patients in good outcome ca...