G Leardini,C Bernardi,E Vaccaro
G Leardini
The anti-TNF-alpha are undoubtedly an efficacious cure in the treatment of rheumatoid arthritis, but their costs are so high that a thorough pharmacoeconomical evaluation is needed in order to identify the specific conditions in which their...
[The safety of interleukin-1 receptor antagonist (anakinra) in the treatment of rheumatoid arthritis] [0.03%]
白细胞介素-1受体拮抗剂（阿那白滞素）治疗类风湿性关节炎的临床安全性分析
L Riente
L Riente
The safety profile of interleukin-1 receptor antagonist (anakinra) has been studied with randomised, placebo-controlled trials involving 2932 patients affected by rheumatoid arthritis. The most frequently reported adverse events were repres...
[IL-1Ra (recombinant human IL-1 receptor antagonist) in the treatment of rheumatoid arthritis: the efficacy] [0.03%]
重组人白细胞介素-1受体拮抗剂治疗类风湿性关节炎的疗效观察
U Fiocco,M Vezzù,L Cozzi et al.
U Fiocco et al.
Interleukin 1 receptor antagonist (IL-1Ra) is a naturally occurring IL-1 inhibitor, acting as a "receptor antagonist", which blocks IL-1 mediated signal transduction. In 1990 IL-1Ra was cloned and later on, a large numbers of studies led to...
M C Boissier,N Bessis
M C Boissier
Rheumatoid arthritis (RA) is a severe autoimmune systemic disease. Chronic synovial inflammation results in destruction of the joints. No conventional treatment is efficient in RA. Gene therapy of RA targets mainly the players of inflammati...
[Reconstructing the pyramid as a therapeutic approach to rheumatoid arthritis] [0.03%]
[重塑金字塔作为治疗类风湿性关节炎的方法]
G Ferraccioli
G Ferraccioli
Several recent clinical studies have clearly established that rheumatoid arthritis (RA) is a disease identifiable since its early phases, a disease that can be adequately and efficaciously treated provided the therapeutic program can be sta...
M Cutolo
M Cutolo
Interleukin-1 (IL-1) is one of the pivotal cytokines in initiating and driving the processes of rheumatoid arthritis (RA), and the body's natural response, IL-1 receptor antagonist (IL-1Ra), has been shown conclusively to block its effects....
[Correlation between radiographic, echographic and MRI changes and rheumatoid arthritis progression] [0.03%]
放射学、超声及磁共振成像改变与类风湿性关节炎进展的相关性
M A Cimmino,M Parodi,E Silvestri et al.
M A Cimmino et al.
Objectives: To review the imaging methods used for the evaluation of disease progression in rheumatoid arthritis (RA) and to evaluate the results of their application in pharmacological trials. ...
C Montecucco
C Montecucco
Predicting which patients will develop severe rheumatoid arthritis is essential for selection of the most appropriate treatment regimen in early arthritis. The key outcomes in rheumatoid arthritis are persistence of the disease, joint damag...
G Valesini,F Barone,D Bompane et al.
G Valesini et al.
The pathogenesis of Rheumatoid Arthritis (RA) is still largely unknown. From the seminal experimental studies, suggesting a multifactorial mechanism leaded by an antigen specific activation, the direct role of innate immunity in the disease...
[Biological modulation of IL-1 activity: role and development of its natural inhibitor IL-1Ra] [0.03%]
[细胞因子il-1活性的生物学调控：其天然抑制因子il-1ra的作用及发展]
J-M Dayer
J-M Dayer
IL-1 and TNF-alpha are potent inducers of matrix metalloproteinases (MMP), eicosanoids, nitric oxide oxydase (iNOS), receptor activator of NF-kB ligand (RANKL), products involved in the destruction of the extracellular matrix, the cartilage...