Pavel Polák,Jana Špeldová,Monika Bratová et al.
Pavel Polák et al.
Pembrolizumab belongs to so called immune checkpoint inhibitors. Frequent adverse event of this therapy is hypothyroidism. The authors present a case report of patient treated with pembrolizumab for non-small cell lung carcinoma, in whom se...
Case Reports
Vnitrni lekarstvi. 2021 Summer;67(3):175-179. DOI: 2021
Jan Vachek
Jan Vachek
Moxonidine is an oral antihypertensive drug from the group of 2nd generation sympatholytics. In patients with mild to moderate hypertension, moxonidine lowers blood pressure (BP) as effectively as most first-line antihypertensives when used...
Rivaroxaban for the treatment and prevention of reccurence of venous thromboembolism in children [0.03%]
用于儿童静脉血栓栓塞性疾病治疗和预防复发的利伐沙班研究
Eliška Boženková,Miroslav Souček
Eliška Boženková
Venous thromboembolism in children is rare, but the incidence has increased sharply during the last years. The standard of care for treating this disease consists of warfarin, unfractionated heparin, low-molecular-weight heparins and fondap...
Therapy of 3 patients with Erdhiem-Chester disease with cladribin or cladribin in combination with cyclophosphamide. Case report and review of the therapy [0.03%]
克拉屈滨或克拉屈滨与环磷酰胺联用治疗3例 Erdheim-Chester 病患者的疗效：病例报告及文献复习
Zdeněk Král,Zdeněk Řehák,Marta Krejčí et al.
Zdeněk Král et al.
Three adult patients with confirmed Erdheim-Chester disease (ECD) are followed at our department. Cladribine in monotherapy or in combination with cyclophosphamide were used for first line therapy. The median number of cycles of cladribine ...
Case Reports
Vnitrni lekarstvi. 2021 Summer;67(3):157-164. DOI: 2021
Petra Bělohlávková
Petra Bělohlávková
The heterogeneous nature of myelodysplastic syndrome (MDS) brings a very variable prognosis of patients with the need for individualized treatment. The prognosis and treatment depend on the conventional determination of IPSS (International ...
What's new in the 2020 update of the CEAP classification system of chronic venous disease? [0.03%]
2020年CEAP慢性静脉疾病分类系统更新要点
Dalibor Musil
Dalibor Musil
The aim of the 2020 update of the CEAP (Clinical-Etiology-Anatomy-Pathophysiology) classification is provide the reproducibility of clinical findings between physicians, enable comparison of old and new versions of the CEAP classification, ...
Don't we forget about biological therapy of hypercholesterolemia with PCSK9-inhibitors? [0.03%]
我们不会忘记用PCSK9抑制剂进行高胆固醇的生物治疗吗？
Vladimír Soška,Ondřej Kyselák
Vladimír Soška
In many patients it is difficult to achieve the current very low target LDL-cholesterol levels, recommended for the prevention of atherosclerotic cardiovascular events. If statin therapy or statins in combination with ezetimibe are not suff...
Šárka Špeciánová
Šárka Špeciánová
Application of intestinal microbiome (Fecal Microbiota Transplantation) is currently discussed treatment procedure which is the subject of professional interest not only when it comes to its medical aspects, but also its legal regulation. T...
Bashar Aldhoon
Bashar Aldhoon
In response to the COVID-19 pandemic many health care systems have attempted to reorganize healthcare workforce. Many doctors and nurses have been redeployed to acute care wards. In order to ensure the best quality of care it is essential f...
Veronika Zvárová,Jiří Dolina,Michal Šenkyřík et al.
Veronika Zvárová et al.
Liver cirrhosis is a chronic liver disease in which the liver tissue and the vascular beds are remodeled leading to impaired hepatic function. Portal hypertension and subsequent esophageal varices are a frequent complication of liver cirrho...