Combining cytotoxic agents with continuous dose levels in seamless phase I-II clinical trials [0.03%]
基于无缝设计的一期和二期临床试验中细胞毒性药物连续剂量水平的组合研究
José L Jiménez,Mourad Tighiouart
José L Jiménez
Phase I-II cancer clinical trial designs are intended to accelerate drug development. In cases where efficacy cannot be ascertained in a short period of time, it is common to divide the study in two stages: i) a first stage in which dose is...
Utility-based Bayesian personalized treatment selection for advanced breast cancer [0.03%]
基于效用的贝叶斯个性化治疗选择在晚期乳腺癌中的应用
Juhee Lee,Peter F Thall,Bora Lim et al.
Juhee Lee et al.
A Bayesian method is proposed for personalized treatment selection in settings where data are available from a randomized clinical trial with two or more outcomes. The motivating application is a randomized trial that compared letrozole plu...
Bayesian modelling strategies for borrowing of information in randomised basket trials [0.03%]
随机篮子试验中借信息的贝叶斯建模策略
Luke O Ouma,Michael J Grayling,James M S Wason et al.
Luke O Ouma et al.
Basket trials are an innovative precision medicine clinical trial design evaluating a single targeted therapy across multiple diseases that share a common characteristic. To date, most basket trials have been conducted in early-phase oncolo...
Yang Li,Hao Liu,Xiaoshen Wang et al.
Yang Li et al.
Length of stay (LOS) is an essential metric for the quality of hospital care. Published works on LOS analysis have primarily focused on skewed LOS distributions and the influences of patient diagnostic characteristics. Few authors have cons...
Daniel K Sewell
Daniel K Sewell
Screening is a powerful tool for infection control, allowing for infectious individuals, whether they be symptomatic or asymptomatic, to be identified and isolated. The resource burden of regular and comprehensive screening can often be pro...
Assessing predictive discrimination performance of biomarkers in the presence of treatment-induced dependent censoring [0.03%]
在治疗诱导的依赖性删失存在的情况下评估生物标志物的预测区分性能
Cuihong Zhang,Jing Ning,Steven H Belle et al.
Cuihong Zhang et al.
In medical studies, some therapeutic decisions could lead to dependent censoring for the survival outcome of interest. This is exemplified by a study of paediatric acute liver failure, where death was subject to dependent censoring due to l...
Sean M Devlin,Alexia Iasonos,John O&#x;Quigley
Sean M Devlin
We develop three approaches to phase I dose finding designs for engineered T cells in oncology. Our goal is to address a very particular difficulty in this clinical setting: an inability to fully administer the dose allocated to some patien...
Regularized regression on compositional trees with application to MRI analysis [0.03%]
基于正则化的组合树回归及其在磁共振成像分析中的应用
Bingkai Wang,Brian S Caffo,Xi Luo et al.
Bingkai Wang et al.
A compositional tree refers to a tree structure on a set of random variables where each random variable is a node and composition occurs at each non-leaf node of the tree. As a generalization of compositional data, compositional trees handl...
Generalizing trial evidence to target populations in non-nested designs: Applications to AIDS clinical trials [0.03%]
非嵌套设计中将试验证据推广至目标人群的研究：艾滋病临床试验中的应用
Fan Li,Ashley L Buchanan,Stephen R Cole
Fan Li
Comparative effectiveness evidence from randomized trials may not be directly generalizable to a target population of substantive interest when, as in most cases, trial participants are not randomly sampled from the target population. Motiv...
Shaun R Seaman,Pantelis Samartsidis,Meaghan Kall et al.
Shaun R Seaman et al.
Understanding the trajectory of the daily number of COVID-19 deaths is essential to decisions on how to respond to the pandemic, but estimating this trajectory is complicated by the delay between deaths occurring and being reported. In Engl...