S A Sohrab
S A Sohrab
Plantar reflex has been an integral component of neurological examination since its introduction more than a century ago. Despite its simplicity of description, elicitation and interpretation of the reflex and inter-observer agreement have ...
L Tyvaert
L Tyvaert
The International League Against Epilepsy (ILAE) is proposing a new nomenclature, replacing the confusing term antiepileptic drugs (AEDs) with antiseizure medications (ASMs). This approach has been partly motivated by the emergence of new t...
Detection of brain somatic mutations from stereo-EEG electrodes in focal epilepsy: Current advances and future perspectives [0.03%]
癫痫局灶性脑区内嵌式皮层电极检测体细胞突变的现状与未来展望
R Checri,S Baldassari,S Baulac
R Checri
Brain somatic mutations are increasingly recognized as major drivers of focal epilepsy particularly in malformations of cortical development. While traditionally relying on surgically resected tissue for genetic analysis, recent advances in...
H Catenoix,W Grabon,S Rheims et al.
H Catenoix et al.
Epilepsy is a notable comorbidity in multiple sclerosis (MS), with a prevalence significantly higher than in the general population. This co-occurrence suggests shared pathophysiological mechanisms, including cortical demyelination, chronic...
Artificial intelligence applied to epilepsy imaging: Current status and future perspectives [0.03%]
应用于癫痫影像的人工智能：现状与未来展望
M Berger,R Licandro,K-H Nenning et al.
M Berger et al.
In recent years, artificial intelligence (AI) has become an increasingly prominent focus of medical research, significantly impacting epileptology as well. Studies on deep learning (DL) and machine learning (ML) - the core of AI - have expl...
Sophie Dupont
Sophie Dupont
Numerous epidemiological and pathophysiological arguments suggest a bidirectional link between late-onset epilepsy and Alzheimer's disease. However, the temporal and causal relationship between the pathophysiological processes underlying th...
Trends in the real-world management of patients with active relapsing-remitting multiple sclerosis treated with natalizumab (TYSABRI®) in France: An analysis of the PMSI database over five years (2019-2023) [0.03%]
法国接受那他珠单抗(TYSABRI®)治疗的活动性复发缓解型多发性硬化症患者的现实世界管理趋势：五年(PMSI数据库)(2019-2023年)分析
E Le Page,C Emery,A Fravalo et al.
E Le Page et al.
Several factors are changing the way relapsing-remitting multiple sclerosis (RRMS) is currently managed with natalizumab (NTZ), with increasing use of injections in home hospitalization structures, change in treatment formulation, strategy ...
Recent progress and challenges in gene therapy for pharmacoresistant focal epilepsy [0.03%]
药物难治性局灶性癫痫基因治疗的近期进展和挑战
D M Kullmann
D M Kullmann
Pharmacoresistant focal epilepsy represents a major unmet need. Recent years have seen several gene therapy strategies validated mainly in rodent models of temporal lobe epilepsy, and some of these have been de-risked for clinical trials. T...
F Bartolomei,J Makhalova,J Benoit et al.
F Bartolomei et al.
Temporal lobe epilepsies (TLEs) are among the forms of epilepsy most frequently encountered in surgical evaluations, characterized by a wide range of anatomical, functional, and electroclinical subtypes. Traditional classifications, such as...
C Alvarado-Rojas,G Huberfeld
C Alvarado-Rojas
Artificial intelligence (AI) is progressively transforming all fields of medicine, promising substantial changes in clinical practice. In the context of epilepsy, electroencephalography (EEG), a technique used for over a century, has histor...