Application of Rhodium-Catalyzed Cyclohydrocarbonylation to the Syntheses of Enantiopure Homokainoids [0.03%]
钌催化环烃化在合成纯荷包酸中的应用
Wen-Hua Chiou,Angèle Schoenfelder,André Mann et al.
Wen-Hua Chiou et al.
Kainic acid, rigidified (S)-glutamic acid, is a well-known kainite receptor agonist for the excitatory transmission in the central nerve system. Our interest in highly selective kainite ligands, prompted us to design a series of new kainic ...
Minimalist proteins: Design of new molecular recognition scaffolds [0.03%]
minimalist proteins：新分子识别支架的设计
Jumi A Shin
Jumi A Shin
We hypothesize that we can exploit what Nature has already evolved by manipulating the alpha-helix molecular recognition scaffold. Therefore, minimalist proteins capable of sequence-specific, high-affinity binding of DNA were generated to p...
Alexander A Bachmanov,Danielle R Reed,Xia Li et al.
Alexander A Bachmanov et al.
Inbred mouse strains display marked differences in avidity for sweet solutions due in part to genetic differences among strains. Using several techniques, we have located a number of regions throughout the genome that influence sweetener ac...
Redesigning nucleic acids [0.03%]
核苷酸的重新设计
S A Benner,T R Battersby,B Eschgfaller et al.
S A Benner et al.
A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit geneti...
G F Joyce
G F Joyce
An RNA-based evolution system was constructed in the laboratory and used to develop RNA enzymes with novel catalytic function. By controlling the nature of the catalytic task that the molecules must perform in order to survive, it is possib...
O Isler,R Rüegg,U Schwieter
O Isler