Understanding Dichromic Fluorescence Manifested in Certain ICG Analogs [0.03%]
理解某些ICG类似物中表现出的二色荧光性质
Zongren Zhang,Jeff Kao,André D&#x;Avignon et al.
Zongren Zhang et al.
Fluorescence has advanced our understanding in various aspects of biological processes. Fluorescence in the near infrared (NIR) region avoids background autofluorescence from biological samples leading to improved image quality. In searchin...
Phosphoramidite-Rhodium Complexes as Catalysts for the Asymmetric [2+2+2] Cycloaddition of Alkenyl Isocyanates and Alkynes [0.03%]
用于烯基异氰酸酯和炔烃[2+2+2]环加成反应的磷酰胺-铑催化剂研究
Rebecca Keller Friedman,Kevin M Oberg,Derek M Dalton et al.
Rebecca Keller Friedman et al.
The discovery and development of the asymmetric rhodium-catalyzed [2+2+2] cycloaddition of alkenyl isocyanates and exogenous alkynes to form indolizinone and quinolizinone scaffolds is described. This methodology has been expanded to includ...
An ignored risk factor in toxicology: The total imprecision of exposure assessment [0.03%]
毒理学中被忽略的风险因素：暴露评估的总不精确性
Philippe Grandjean,Esben Budtz-Jørgensen
Philippe Grandjean
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of ...
David R Williams,Martin J Walsh,Christopher D Claeboe et al.
David R Williams et al.
The process of allylic transposition in S(E)' reactions is a significant construct for synthesis. The flexibility of a variety of allylation strategies provides for the rational design of pathways to a diverse array of complex targets. Our ...
Recent Applications of Imines as Key Intermediates in the Synthesis of Alkaloids and Novel Nitrogen Heterocycles [0.03%]
近期利用亚胺作为合成生物碱和新型氮杂环化合物的关键中间体的研究进展
Stephen F Martin
Stephen F Martin
One of the major challenges in contemporary synthetic organic chemistry is the design and development of new tactics and strategies and their application to concise and efficient syntheses of biologically active natural products. Strategies...
A Douglas Kinghorn,Esperanza J Carcache de Blanco,Hee-Byung Chai et al.
A Douglas Kinghorn et al.
A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi....
Application of Rhodium-Catalyzed Cyclohydrocarbonylation to the Syntheses of Enantiopure Homokainoids [0.03%]
钌催化环烃化在合成纯荷包酸中的应用
Wen-Hua Chiou,Angèle Schoenfelder,André Mann et al.
Wen-Hua Chiou et al.
Kainic acid, rigidified (S)-glutamic acid, is a well-known kainite receptor agonist for the excitatory transmission in the central nerve system. Our interest in highly selective kainite ligands, prompted us to design a series of new kainic ...
Minimalist proteins: Design of new molecular recognition scaffolds [0.03%]
minimalist proteins：新分子识别支架的设计
Jumi A Shin
Jumi A Shin
We hypothesize that we can exploit what Nature has already evolved by manipulating the alpha-helix molecular recognition scaffold. Therefore, minimalist proteins capable of sequence-specific, high-affinity binding of DNA were generated to p...
Alexander A Bachmanov,Danielle R Reed,Xia Li et al.
Alexander A Bachmanov et al.
Inbred mouse strains display marked differences in avidity for sweet solutions due in part to genetic differences among strains. Using several techniques, we have located a number of regions throughout the genome that influence sweetener ac...