Joseph Moran,Michael J Krische
Joseph Moran
Ruthenium-catalyzed transfer hydrogenation of diverse π-unsaturated reactants in the presence of aldehydes provides products of carbonyl addition. Dehydrogenation of primary alcohols in the presence of the same π-unsaturated reactants pro...
First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme [0.03%]
(±)-2-甲氧基-6-十七炔酸和相关2-甲氧基化类似物作为有效抑制利什曼原生动物拓扑异构酶IB的首例全合成化合物
Néstor M Carballeira,Michelle Cartagena,Fengyu Li et al.
Néstor M Carballeira et al.
The fatty acids (±)-2-methoxy-6Z-heptadecenoic acid (1), (±)-2-methoxy-6-heptadecynoic acid (2) and (±)-2-methoxyheptadecanoic acid (3) were synthesized and their inhibitory activity against the Leishmania DNA topoisomerase IB enzyme (Ld...
Synthesis of Lipid A and Inner Core LPS ligands containing 4-amino-4-deoxy-l-arabinose units [0.03%]
含4-氨基-4-脱氧-L-阿拉伯糖单位的脂质A和内核LPS配体合成
Alla Zamyatina,Ralph Hollaus,Markus Blaukopf et al.
Alla Zamyatina et al.
Attachment of 4-amino-4-deoxy-l-arabinose to phosphates or sugar hydroxyl groups of lipopolysaccharide contributes to bacterial resistance against common antibiotics. For a detailed study of antigenic properties and binding interactions, Ar...
Balancing life with glycoconjugates: monitoring unfolded protein response-mediated anti-angiogenic action of tunicamycin by Raman Spectroscopy [0.03%]
糖复合物与生命平衡：利用拉曼光谱技术监测硫酸粘多糖的未折叠蛋白反应介导的抗血管生成作用
Maria O Longas,Ashok Kotapati,Kilari Pvrk Prasad et al.
Maria O Longas et al.
Asparagine-linked protein glycosylation is a hallmark for glycoprotein structure and function. Its impairment by tunicamycin [a competitive inhibitor of N-acetylglucosaminyl 1-phosphate transferase (GPT)] has been known to inhibit neo-vascu...
Design, synthesis, and characterization of novel nanowire structures for photovoltaics and intracellular probes [0.03%]
新型纳米线结构的设计、合成与表征用于光伏和胞内探测器
Bozhi Tian,Charles M Lieber
Bozhi Tian
Semiconductor nanowires (NWs) represent a unique system for exploring phenomena at the nanoscale and are expected to play a critical role in future electronic, optoelectronic, and miniaturized biomedical devices. Modulation of the compositi...
Brian P Jackson,Vivien F Taylor,Tracy Punshon et al.
Brian P Jackson et al.
Arsenic exposure to humans is pervasive, and, increasingly, studies are revealing adverse health effects at ever lower doses. Drinking water is the main route of exposure for many individuals; however, food can be a significant source of ar...
Sze-Sze Ng,Chun-Yu Ho,Kristin D Schleicher et al.
Sze-Sze Ng et al.
Several reactions of simple, unactivated alkenes with electrophiles under nickel(0) catalysis are discussed. The coupling of olefins with aldehydes and silyl triflates provides allylic or homoallylic alcohol derivatives, depending on the su...
The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements [0.03%]
G-四聚体/i- motif二级结构作为顺式作用调控元件的作用
Samantha Kendrick,Laurence H Hurley
Samantha Kendrick
The nature of DNA has captivated scientists for more than fifty years. The discovery of the double-helix model of DNA by Watson and Crick in 1953 not only established the primary structure of DNA, but also provided the mechanism behind DNA ...
Julie A Aaron,David W Christianson
Julie A Aaron
Terpenoid synthases are ubiquitous enzymes that catalyze the formation of structurally and stereochemically diverse isoprenoid natural products. Many isoprenoid coupling enzymes and terpenoid cyclases from bacteria, fungi, protists, plants,...
Lessons from the Total Synthesis of (±) Phalarine: Insights Into the Mechanism of the Pictet-Spengler Reaction [0.03%]
菲拉林的全合成及其对派克特-施彭格勒反应机理的新认识
John D Trzupek,Chaomin Li,Collin Chan et al.
John D Trzupek et al.
The furanobisindole alkaloid, phalarine, possesses a unique structural framework within the alkaloid family of natural products. Our laboratory recently disclosed the racemic total synthesis of phalarine, featuring an efficient azaspiroindo...