Sze-Sze Ng,Chun-Yu Ho,Kristin D Schleicher et al.
Sze-Sze Ng et al.
Several reactions of simple, unactivated alkenes with electrophiles under nickel(0) catalysis are discussed. The coupling of olefins with aldehydes and silyl triflates provides allylic or homoallylic alcohol derivatives, depending on the su...
The role of G-quadruplex/i-motif secondary structures as cis-acting regulatory elements [0.03%]
G-四聚体/i- motif二级结构作为顺式作用调控元件的作用
Samantha Kendrick,Laurence H Hurley
Samantha Kendrick
The nature of DNA has captivated scientists for more than fifty years. The discovery of the double-helix model of DNA by Watson and Crick in 1953 not only established the primary structure of DNA, but also provided the mechanism behind DNA ...
Julie A Aaron,David W Christianson
Julie A Aaron
Terpenoid synthases are ubiquitous enzymes that catalyze the formation of structurally and stereochemically diverse isoprenoid natural products. Many isoprenoid coupling enzymes and terpenoid cyclases from bacteria, fungi, protists, plants,...
Lessons from the Total Synthesis of (±) Phalarine: Insights Into the Mechanism of the Pictet-Spengler Reaction [0.03%]
菲拉林的全合成及其对派克特-施彭格勒反应机理的新认识
John D Trzupek,Chaomin Li,Collin Chan et al.
John D Trzupek et al.
The furanobisindole alkaloid, phalarine, possesses a unique structural framework within the alkaloid family of natural products. Our laboratory recently disclosed the racemic total synthesis of phalarine, featuring an efficient azaspiroindo...
Understanding Dichromic Fluorescence Manifested in Certain ICG Analogs [0.03%]
理解某些ICG类似物中表现出的二色荧光性质
Zongren Zhang,Jeff Kao,André D&#x;Avignon et al.
Zongren Zhang et al.
Fluorescence has advanced our understanding in various aspects of biological processes. Fluorescence in the near infrared (NIR) region avoids background autofluorescence from biological samples leading to improved image quality. In searchin...
Phosphoramidite-Rhodium Complexes as Catalysts for the Asymmetric [2+2+2] Cycloaddition of Alkenyl Isocyanates and Alkynes [0.03%]
用于烯基异氰酸酯和炔烃[2+2+2]环加成反应的磷酰胺-铑催化剂研究
Rebecca Keller Friedman,Kevin M Oberg,Derek M Dalton et al.
Rebecca Keller Friedman et al.
The discovery and development of the asymmetric rhodium-catalyzed [2+2+2] cycloaddition of alkenyl isocyanates and exogenous alkynes to form indolizinone and quinolizinone scaffolds is described. This methodology has been expanded to includ...
An ignored risk factor in toxicology: The total imprecision of exposure assessment [0.03%]
毒理学中被忽略的风险因素：暴露评估的总不精确性
Philippe Grandjean,Esben Budtz-Jørgensen
Philippe Grandjean
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of ...
David R Williams,Martin J Walsh,Christopher D Claeboe et al.
David R Williams et al.
The process of allylic transposition in S(E)' reactions is a significant construct for synthesis. The flexibility of a variety of allylation strategies provides for the rational design of pathways to a diverse array of complex targets. Our ...
Recent Applications of Imines as Key Intermediates in the Synthesis of Alkaloids and Novel Nitrogen Heterocycles [0.03%]
近期利用亚胺作为合成生物碱和新型氮杂环化合物的关键中间体的研究进展
Stephen F Martin
Stephen F Martin
One of the major challenges in contemporary synthetic organic chemistry is the design and development of new tactics and strategies and their application to concise and efficient syntheses of biologically active natural products. Strategies...
A Douglas Kinghorn,Esperanza J Carcache de Blanco,Hee-Byung Chai et al.
A Douglas Kinghorn et al.
A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi....