Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis [0.03%]
核苷酸磷酸酶负调节CXCR4介导的G蛋白活化和化学趋向性
Wenbo Zhang,Jean-Marc Navenot,Nicole M Frilot et al.
Wenbo Zhang et al.
CXCR4, the primary receptor for CXCL12, plays a critical role in the development of hematopoietic, vascular, central nervous, and immune systems by mediating directional migration of precursor cells. This mechanism promotes homing of tumor ...
Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor [0.03%]
人源血清素5-HT2A受体激动剂配体结合和效力的丝氨酸5.43（239）和5.46（242）的作用评估
Michael R Braden,David E Nichols
Michael R Braden
We assessed the relative importance of two serine residues located near the top of transmembrane helix 5 of the human 5-HT(2A) receptor, comparing the wild type with S5.43(239)A or S5.46(242)A mutations. Using the ergoline lysergic acid die...
Disruption of clock gene expression alters responses of the aryl hydrocarbon receptor signaling pathway in the mouse mammary gland [0.03%]
时钟基因表达紊乱扰乱小鼠乳腺芳烃受体信号通路反应
Xiaoyu Qu,Richard P Metz,Weston W Porter et al.
Xiaoyu Qu et al.
The biological effects of many environmental toxins are mediated by genes containing Per-Arnt-Sim (PAS) domains, the aryl hydrocarbon receptor (AhR), and AhR nuclear translocator. Because these transcription factors interact with other PAS ...
Gbetagamma interferes with Ca2+-dependent binding of synaptotagmin to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex [0.03%]
Gbethetagamma干扰Ca2+依赖性结合到可溶的N-乙基马来酰亚胺敏感因素附着蛋白受体（SNARE）复合物中
Eun-Ja Yoon,Tatyana Gerachshenko,Bryan D Spiegelberg et al.
Eun-Ja Yoon et al.
Presynaptic inhibitory G protein-coupled receptors (GPCRs) can decrease neurotransmission by inducing interaction of Gbetagamma with the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex. We have shown th...
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution [0.03%]
人类细胞色素P450 2B6的理性工程改造可增强其表达和稳定性：Leu264->Phe取代的重要性
Santosh Kumar,Yonghong Zhao,Ling Sun et al.
Santosh Kumar et al.
Despite the emerging importance of human P450 2B6 in xenobiotic metabolism, thorough biochemical and biophysical characterization has been impeded as a result of low expression in Escherichia coli. Comparison with similar N-terminal truncat...
Evaluation of action mechanisms of toxic chemicals using JFCR39, a panel of human cancer cell lines [0.03%]
人癌细胞系板(JFCR39)在有毒化学品作用机制评估中的应用研究
Noriyuki Nakatsu,Tomoki Nakamura,Kanami Yamazaki et al.
Noriyuki Nakatsu et al.
We previously established a panel of human cancer cell lines, JFCR39, coupled to an anticancer drug activity database; this panel is comparable with the NCI60 panel developed by the National Cancer Institute. The JFCR39 system can be used t...
Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70 [0.03%]
牻牛儿基牻牛儿基乙酸酯通过诱导70kDa热休克蛋白(HSP70)的表达来激发未折叠蛋白数目变化并独立于HSP70决定细胞命运
Satoshi Endo,Nobuhiko Hiramatsu,Kunihiro Hayakawa et al.
Satoshi Endo et al.
Geranylgeranylacetone (GGA), an antiulcer agent, has the ability to induce 70-kDa heat shock protein (HSP70) in various cell types and to protect cells from apoptogenic insults. However, little is known about effects of GGA on other HSP fam...
Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1 [0.03%]
由皮层蛋白调节D1型多巴胺受体的转运和信号转导
Michael M C Kong,Ahmed Hasbi,Michael Mattocks et al.
Michael M C Kong et al.
There is accumulating evidence that G protein-coupled receptor signaling is regulated by localization in lipid raft microdomains. In this report, we determined that the D1 dopamine receptor (D1R) is localized in caveolae, a subset of lipid ...
Role of protein kinase Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries [0.03%]
蛋白激酶Cζ及其适配蛋白p62在肺动脉电压门控钾通道调节中的作用
Laura Moreno,Giovanna Frazziano,Angel Cogolludo et al.
Laura Moreno et al.
Voltage-gated potassium (K(V)) channels play an essential role in regulating pulmonary artery function, and they underpin the phenomenon of hypoxic pulmonary vasoconstriction. Pulmonary hypertension is characterized by inappropriate vasocon...
Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor [0.03%]
葡萄糖调节蛋白94和HSP90在CB2型大麻素受体介导的细胞迁移中的作用：HSP90在G蛋白藕联受体迁移信号转导中的新作用
Fang He,Zhuan-Hong Qiao,Jian Cai et al.
Fang He et al.
The endocannabinoid 2-arachidonoylglycerol (2-AG) enhances cell migration through the CB2 cannabinoid receptor. In this study, using an immunoprecipitation and mass spectrometry-based proteomic approach, we first identified the 90-kDa heat ...