Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer [0.03%]
定量生物发光共振能量转移法检测活细胞中的阿片受体同源和异源二聚化
Danxin Wang,Xiaochun Sun,Laura M Bohn et al.
Danxin Wang et al.
Opioid receptors have been shown to dimerize or oligomerize among themselves and each other, affecting their functional properties. This study used bioluminescence resonance energy transfer (BRET) between the mu, delta, and kappa opioid rec...
Comparative Study
Molecular pharmacology. 2005 Jun;67(6):2173-84. DOI:10.1124/mol.104.010272 2005
Potential role of cAMP response element-binding protein in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene transcription in fetal mouse cortical cells [0.03%]
环磷腺苷反应元件结合蛋白在酒精诱导的胎儿小鼠皮质细胞N-甲基-D-天冬氨酸受体2B亚单位基因转录中的潜在作用
C S Sheela Rani,Mei Qiang,Maharaj K Ticku
C S Sheela Rani
We have shown previously that long-term ethanol treatment causes an up-regulation of N-methyl-D-aspartate (NMDA) receptor 2B subunit (NR2B) number and function in cultured fetal mouse cortical neurons. To examine the intracellular signaling...
Comparative Study
Molecular pharmacology. 2005 Jun;67(6):2126-36. DOI:10.1124/mol.104.007872 2005
Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation [0.03%]
蛋白激酶C对5-羟色胺转运蛋白功能、内吞作用和磷酸化产生双相效应的证据
Lankupalle D Jayanthi,Devadoss J Samuvel,Randy D Blakely et al.
Lankupalle D Jayanthi et al.
The serotonin transporter (SERT) regulates 5-hydroxytryptamine (serotonin) (5-HT) neurotransmission and is a high-affinity target for antidepressants and psychostimulants. In the present study, we investigated the mechanisms that contribute...
Comparative Study
Molecular pharmacology. 2005 Jun;67(6):2077-87. DOI:10.1124/mol.104.009555 2005
Differential spatial approximation between cholecystokinin residue 30 and receptor residues in active and inactive conformations [0.03%]
活性和非活性构象下胆囊收缩素残基30与受体残基的空间相对定位差异
Maoqing Dong,Elizabeth M Hadac,Delia I Pinon et al.
Maoqing Dong et al.
Understanding the structures of active and inactive agonist- and antagonist-bound receptor complexes is of great interest. In this work, we focus on position 30 of cholecystokinin (CCK) and its spatial approximation with the type A CCK rece...
Activating protein 1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun [0.03%]
激活蛋白1介导的环氧合酶-2表达独立于c-Jun氨基末端磷酸化
Lei-Chin Chen,Ben-Kuen Chen,Wen-Chang Chang
Lei-Chin Chen
Transcriptional activation of the cyclooxygenase (COX)-2 gene is responsible for high level of prostaglandin production during inflammation and carcinogenesis. We found previously that c-Jun induction plays a crucial role in epidermal growt...
Comparative Study
Molecular pharmacology. 2005 Jun;67(6):2057-69. DOI:10.1124/mol.104.010900 2005
Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1 [0.03%]
促动力素2β的鉴定与药理学表征及其作为促动力素受体1的选择性配体作用
Jingcai Chen,Chester Kuei,Steven Sutton et al.
Jingcai Chen et al.
Prokineticins 1 and 2 (PK1 and PK2) have been recently identified from humans and other mammals and play multiple functional roles. PK proteins are ligands for two G protein-coupled receptors, PK receptor 1 (PKR1) and PK receptor 2 (PKR2). ...
Comparative Study
Molecular pharmacology. 2005 Jun;67(6):2070-6. DOI:10.1124/mol.105.011619 2005
Expression of native alpha3beta4* neuronal nicotinic receptors: binding and functional studies investigating turnover of surface and intracellular receptor populations [0.03%]
表达α3β4*原代神经尼古丁乙酰胆碱受体：研究细胞表面和胞内受体库的更新机制
R Benjamin Free,Susan B McKay,Paul D Gottlieb et al.
R Benjamin Free et al.
Several pathological conditions involve alterations in expression of neuronal nicotinic acetylcholine receptors (nAChRs). Although some studies have addressed processes involved with muscle nAChR expression, knowledge of the regulation of n...
Comparative Study
Molecular pharmacology. 2005 Jun;67(6):2040-8. DOI:10.1124/mol.104.009282 2005
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action [0.03%]
抗癌前药7-乙基-10-[4-(1-哌啶)-1-哌啶]-卡博氧(camptothecin (cpt-11))与torpedocalifornica乙酰胆碱酯酶的复合金刚石结构为其胆碱能效应提供了分子解释
Michal Harel,Janice L Hyatt,Boris Brumshtein et al.
Michal Harel et al.
The anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino-]carbonyloxycamptothecin (CPT-11) is a highly effective camptothecin analog that has been approved for the treatment of colon cancer. It is hydrolyzed by carboxylesterases to ...
Cell cycle signaling by endothelin-1 requires Src nonreceptor protein tyrosine kinase [0.03%]
血管内皮素-1的细胞周期信号转导需要Src非受体酪氨酸激酶
Rangnath Mishra,Yuan Wang,Michael S Simonson
Rangnath Mishra
Cross-talk between G protein-coupled receptors and protein tyrosine kinases is well established, but the phenotypic consequences of these signaling interactions are not completely understood. To investigate the role of Src family kinases in...
Comparative Study
Molecular pharmacology. 2005 Jun;67(6):2049-56. DOI:10.1124/mol.104.010546 2005
DNA methylation-related chromatin modification in the regulation of mouse delta-opioid receptor gene [0.03%]
DNA甲基化相关染色质修饰在小鼠δ-阿片受体基因表达调控中的作用研究
Guilin Wang,Tiancheng Liu,Li-Na Wei et al.
Guilin Wang et al.
DNA methylation plays critical roles in gene-silencing through chromatin modification. We reported previously that promoter-region CpG methylation repressed mouse delta-opioid receptor (mDOR) gene expression. In the current study, we demons...
Comparative Study
Molecular pharmacology. 2005 Jun;67(6):2032-9. DOI:10.1124/mol.105.011056 2005