Gabriella Liszkay
Gabriella Liszkay
The objective of the work is presentation of the available therapeutic results of the clinical trials with anti CTLA-4 and anti PD-1 treatment, which are operating on the immune checkpoints registered in advanced melanoma, and the results o...
Review
Magyar onkologia. 2016 Mar 2;60(1):11-5. DOI: 2016
Andrea Ladányi
Andrea Ladányi
Immune checkpoint agents, representing a new class of immunotherapeutic modalities, have proven their beneficial effect inducing durable clinical response in a widening spectrum of tumor types. To enhance their efficacy it is of primary imp...
Review
Magyar onkologia. 2016 Mar 2;60(1):4-10. DOI: 2016
[Biologic mechanisms of mitotic abnormalities and chromosome number changes in malignant tumors] [0.03%]
恶性肿瘤有丝分裂异常和染色体数变化的生物学机制
Katalin Hegyi
Katalin Hegyi
The main goal of this work was to study the effect of Aurora kinase expression on cell ploidy and tumorigenesis. Fifty invasive breast cancer, 50 diffuse large B-cell lymphoma and 10 reactive lymph node samples were recruited in the study. ...
Gabriella Liszkay
Gabriella Liszkay
Despite the continuously increasing incidence of melanoma, over decades the therapy has barely changed. However, since 2011 the "still water" moves, now with multiple medications the patient survival can be improved. Dabrafenib is the secon...
[The prognostic role of expression of p16 tumor suppressor gene in Hungarian patients with oral squamous cell carcinoma] [0.03%]
匈牙利口腔鳞癌患者中肿瘤抑制基因p16表达的预后作用研究
Judit Borbála Vánkos,Violetta Piurkó,Zsuzsanna Suba et al.
Judit Borbála Vánkos et al.
Beside smoking and alcohol consumption, human papillomavirus (HPV) infection is the most common risk factor of squamous cell carcinoma in the head and neck region (HNSCC). The latter group of patients associates with better prognosis. Durin...
[PI3K/AKT pathway activation and therapeutic consequences in breast cancer] [0.03%]
[乳腺癌中PI3K/Akt途径活化及其治疗作用]
Judit Olasz,Zoltán Doleschall,Zsuzsanna Dunai et al.
Judit Olasz et al.
The phosphatidylinositol-3-kinase/AKT (PI3K/AKT) pathway is commonly deregulated in breast cancer through several mechanisms, including PI3K catalytic subunit alpha (PIK3CA) mutations and loss of phosphatase and tensin homolog (PTEN). The h...
[Relevance of animal models in the development of compounds targeting multidrug resistant cancer] [0.03%]
药物作用于多药耐药癌症的作用机制及其动物模型的相关性研究
András Füredi,Szilárd Tóth,Lilla Hámori et al.
András Füredi et al.
Anticancer compounds are typically identified in in vitro screens. Unfortunately, the in vitro drug sensitivity of cell lines does not reflect treatment efficiency in animal models, and neither show acceptable correlation to clinical result...
Sarolta Gundy
Sarolta Gundy
The author provides a comprehensive picture on introduction and application of chromosome biodosimetry in Hungary for measuring and estimation of biological doses of ionizing radiation. She describes different mathematical equations existin...
[Potential role of patient-derived tumor xenografts (PDTXs) in the selection of optimal therapeutic strategy] [0.03%]
[基于患者肿瘤异种移植模型（PDTX）的选择最佳治疗方案的潜在作用]
József Tóvári
József Tóvári
The rapid selection of the efficient anticancer therapy may decrease the unwanted burden to patients and has financial consequences. Tumor models including xenografts in mice were used previously mostly in the development of new anticancer ...
[Role of tumour cell invasion/migration in the vascularisation of experimental lung metastases] [0.03%]
肿瘤细胞入侵/迁移在实验性肺转移血管化中的作用
Vanessza Szabó,Edina Bugyik,Katalin Dezsõ et al.
Vanessza Szabó et al.
Treatment of patients with lung metastases remains a major challenge. A possible target for therapies is the inhibition of vascularization of metastases. Our study aimed to determine the possible mechanisms of the experimental lung metastas...