Almost Three Decades of Post-Marketing Experience With A Human Intravenous Immunoglobulin 5%: Analysis of A Propriety Pharmacovigilance Database [0.03%]
人静脉注射免疫球蛋白5%上市后近三十年的用药经验分析：一项基于药物流行病学数据库的研究
Davide Susini,Roberto Crea,Paolo Morabito et al.
Davide Susini et al.
Background: Intravenous immunoglobulin (IVIg) therapies are widely used for replacement and immunomodulatory indications but are associated with known risks of adverse drug reactions (ADRs), underscoring the importance of...
The Berberine Derivative BBR684 Inhibits VDAC Oligomerization to Suppress Ferroptosis in Acute Kidney Injury [0.03%]
巴布期衍生化合物BBR684通过抑制VDAC寡聚化来抑制急性肾损伤中铁死亡的研究
Zihao Jiang,Wenhao Zhang,Jiawei Zhu et al.
Zihao Jiang et al.
Background: Ferroptosis is an iron-dependent form of programmed cell death driven by lipid peroxidation and is implicated in acute kidney injury (AKI). Ob...
A Prospective-Retrospective Observational Cohort Study of Short-Term Health Outcomes of Preterm Very Low Birth Weight Infants Receiving Oropharyngeal Administration of Own Mother's Colostrum [0.03%]
一项前瞻性-回顾性观察队列研究：早期应用自体初乳经口咽喂养对极低出生体重早产儿短期健康结局的影响
Snehal V Mavchi,Rahul M Dawre,Isha Deshmukh et al.
Snehal V Mavchi et al.
Introduction: Mother's milk has been associated with better health outcomes in preterm infants, including reduced sepsis and necrotizing enterocolitis (NEC) severity, as well as improved neurodevelopment. This study aims ...
Conduction of Pragmatic Clinical Trials in Routine Clinical Settings: Guidelines for Development of Protocol [0.03%]
pragmatic临床试验方案的设计指南
Smruti Besekar,Sangita Jogdand,Satywam Singh Patel
Smruti Besekar
Background: The relationships between treatments and real-world healthcare outcomes can be effectively evaluated through the implementation of a pragmatic clinical trial or practical clinical trial (PCT). ...
Acute PGAD-Like Genital Arousal in a 59-Year-Old Woman After Duloxetine Withdrawal: A 36-Month Follow-Up Case Report [0.03%]
度洛西汀撤药后出现急性类似PGAD的女性(59岁)生殖器兴奋：为期36个月的病例报告
Nathan Jacobs,Laurie Ferret,Vassili Fague et al.
Nathan Jacobs et al.
We report the case of a 59-year-old woman who experienced an acute episode of genital arousal symptoms consistent with Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia (PGAD/GPD), but not fulfilling the duration criterion. The ...
Efficacy of Orlistat on Cardiometabolic Indices in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A GRADE-Assessed Systematic Review and Meta-Analysis of RCTs [0.03%]
奥利司他改善代谢功能障碍相关肝脂肪变性患者心代谢指标的疗效：基于RCT的系统评价和GRADE meta分析
Mehdi Karimi,Seyed Morteza Ali Pourfaraji,Peyvand Parhizkar Roudsari et al.
Mehdi Karimi et al.
Background and aim: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiometabolic abnormalities. Orlistat has demonstrated potential benefits on metabolic parameters, yet its effica...
As-Needed Medication Use for Agitation Across Valproic Acid Formulations [0.03%]
不同丙戊酸盐配方的激越按需用药情况分析
Michael Ley,Casey Tiefenthaler,Jamie Kneebusch et al.
Michael Ley et al.
Background: Pharmacokinetic differences between immediate-, delayed- and extended-release (IR, DR, ER) formulations of valproic acid (VPA) may impact therapeutic outcomes. As-needed, pro re nata (PRN) medications may serv...
The Effects of Yacon Consumption on Body Weight and C-reactive Protein: A Systematic Review and Meta-analysis of Randomized Controlled Trials [0.03%]
菊莲果对体重和C-反应蛋白的影响：随机对照试验的系统评价和meta分析
Fariborz Porbafrani,Mohammad Samadi,Karim Parastouei
Fariborz Porbafrani
Background: The rising global challenges of obesity and chronic inflammation contribute to an increased prevalence of metabolic disorders and cardiovascular diseases. ...
Facts and Issues of Submitting Applications (Public Knowledge-Based Applications) for Unapproved and Off-label Drugs With High Medical Needs in Japan [0.03%]
日本高医疗需求未批准药品和超适应症用药公共知识型申请的相关事实与问题分析
Akiko Hinomura,Daisuke Obata,Jun Matsubayashi et al.
Akiko Hinomura et al.
Background: In Japan, to promote the development and application of unapproved and off-label drugs, a review pathway known as the "public knowledge-based application" was established in 1999. This pathway allows companies...
Understanding Pharmacokinetic-Drug Interactions With Drugs Approved by the US Food and Drug Administration in 2024 to Better Manage the Risk of Drug Interactions With Concomitant Medications: A Review of Clinical Data From New Drug Applications [0.03%]
通过回顾新药申请的临床数据来更好地管理与伴随药物相互作用的风险：2024年美国食品药品监督管理局批准的药物中的药代动力学-药物相互作用的理解综述
Jingjing Yu,Sophie Argon,Katie Owens et al.
Jingjing Yu et al.
Objective: This analysis aimed to provide a mechanistic understanding and an evaluation of the clinical relevance of pharmacokinetic drug-drug interactions (DDIs) associated with drugs approved by the Food and Drug Admini...