Elizabeth C Theil,Rabindra K Behera,Takehiko Tosha
Elizabeth C Theil
Ferritins, highly symmetrical protein nanocages, are reactors for Fe2+ and dioxygen or hydrogen peroxide that are found in all kingdoms of life and in many different cells of multicellular organisms. They synthesize iron concentrates requir...
Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols [0.03%]
探究氧化应激：金属离子、活性氧以及硫醇的荧光分子探针
Lynne M Hyman,Katherine J Franz
Lynne M Hyman
Oxidative stress is a common feature shared by many diseases, including neurodegenerative diseases. Factors that contribute to cellular oxidative stress include elevated levels of reactive oxygen species, diminished availability of detoxify...
Applications of pulsed EPR spectroscopy to structural studies of sulfite oxidizing enzymes() [0.03%]
脉冲EPR光谱在亚硫酸盐氧化酶结构研究中的应用()
Eric L Klein,Andrei V Astashkin,Arnold M Raitsimring et al.
Eric L Klein et al.
Sulfite oxidizing enzymes (SOEs), including sulfite oxidase (SO) and bacterial sulfite dehydrogenase (SDH), catalyze the oxidation of sulfite (SO(3) (2-)) to sulfate (SO(4) (2-)). The active sites of SO and SDH are nearly identical, each ha...
Jeffrey J Warren,Maraia E Ener,Antonín Vlček Jr et al.
Jeffrey J Warren et al.
Biological redox machines require efficient transfer of electrons and holes for function. Reactions involving multiple tunneling steps, termed "hopping," often promote charge separation within and between proteins that is essential for ener...
Jeffrey J Warren,Jay R Winkler,Harry B Gray
Jeffrey J Warren
Photosynthetic reaction centers (PRCs) employ multiple-step tunneling (hopping) to separate electrons and holes that ultimately drive the chemistry required for metabolism. We recently developed hopping maps that can be used to interpret th...
Recent advances in phenoxyl radical complexes of salen-type ligands as mixed-valent galactose oxidase models [0.03%]
近年来salen型配体phenox基自由基配合物作为混合价态乳糖氧化酶模型的研究进展
Christopher T Lyons,T Daniel P Stack
Christopher T Lyons
The interplay between redox-active transition metal ions and redox-active ligands in metalloenzyme sites is an area of considerable research interest. Galactose oxidase (GO) is the archetypical example, catalyzing the aerobic oxidation of p...
Iron metabolism in aerobes: managing ferric iron hydrolysis and ferrous iron autoxidation [0.03%]
好氧生物的铁代谢：调控三价铁水解和二价铁自氧化反应
Daniel J Kosman
Daniel J Kosman
Aerobes and anaerobes alike express a plethora of essential iron enzymes; in the resting state, the iron atom(s) in these proteins are in the ferrous state. For aerobes, ferric iron is the predominant environmental valence form which, given...
The Rich Electrochemistry and Redox Reactions of the Copper Sites in the Cellular Prion Protein [0.03%]
细胞朊蛋白中铜位点的丰富电化学和氧化还原反应
Feimeng Zhou,Glenn L Millhauser
Feimeng Zhou
This paper reviews recent electrochemical studies of the copper complexes of prion protein (PrP) and its related peptides, and correlates their redox behavior to chemical and biologically relevant reactions. Particular emphasis is placed on...
Anti-diabetic effects of a series of vanadium dipicolinate complexes in rats with streptozotocin-induced diabetes [0.03%]
钒茋化合物的抗糖尿病作用研究
Gail R Willsky,Lai-Har Chi,Michael Godzala rd et al.
Gail R Willsky et al.
The effects of oral treatment of rats with streptozotocin-induced diabetes with a range of vanadium dipicolinate complexes (Vdipic) and derivatives are reviewed. Structure-reactivity relationships are explored aiming to correlate properties...
Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions [0.03%]
一氧化氮合酶调节机制：电子传递与结构域相互作用
Changjian Feng
Changjian Feng
Nitric oxide synthase (NOS), a flavo-hemoprotein, tightly regulates nitric oxide (NO) synthesis and thereby its dual biological activities as a key signaling molecule for vasodilatation and neurotransmission at low concentrations, and also ...