Optimizing the Production of Therapeutic Bacteriophages Through Quality by Design: A Case Study on Pseudomonas Aeruginosa [0.03%]
基于质量设计的治疗噬菌体生产优化——铜绿假单胞菌噬菌体生产案例研究
Carmen Jungo,Samuel Garcia,Jean-François Brunet et al.
Carmen Jungo et al.
A Failure Modes and Effects Analysis (FMEA) risk assessment was conducted to evaluate and document the criticality of process parameters and material attributes involved in a Pseudomonas aeruginosa phage production process. This assessment ...
Visible Light Induced One-pot Synthesis of Spirocyclopropyl Oxindoles from Isatin Derivatives and Glycine Ester Hydrochloride [0.03%]
以吲哚衍生物和甘氨酸酯盐酸盐为原料的一锅法合成螺环氧化吲哚类化合物
Subhankar Bera,Tejas Prabakar,Khushi Verma et al.
Subhankar Bera et al.
An integrated one pot protocol for the in situ generation of hazardous alkyl diazoacetates (from glycine ester hydrochloride) and their subsequent reaction with 3-alkenyl oxoindoles (generated via the in situ Wittig reaction from isatin der...
Sarban Kumar Yadav,Bhawana Nagar,Basab Bijayi Dhar
Sarban Kumar Yadav
Quinone motifs play a crucial role in a wide range of living organisms, including bacteria, fungi, higher plants, and some animals. They are also present in numerous natural pigments. This review summarizes recent advances in the direct fun...
Green Synthesis of Stereodefined Tri- and Tetrasubstituted Alkenes via 100% Atomeconomic and Regio-, and Stereoselective Halo-chalcogenation and Sulfonylation of Alkynes [0.03%]
通过原子经济百分比的以及区域和立体选择性的卤化/硫属元素化与磺酰化合成非对映体单一的三取代和四取代烯烃
Appanapalli N V Satyanarayana,Tanmay Chatterjee
Appanapalli N V Satyanarayana
Achieving 100% atom economy in an organic transformation is a challenging task but it is always desirable in the context of green chemistry. Difunctionalization of alkynes using a bifunctional reagent is a useful strategy to achieve 100% at...
Mechanochemical Degradation of Active Pharmaceutical Ingredients (APIs): A Simple Tool for the Prediction of Drug Stability [0.03%]
药物稳定性的机械化学降解预测方法研究
Ulrike Holzgrabe,Helmut Buschmann,Norbert Handler et al.
Ulrike Holzgrabe et al.
Knowledge of the potential degradation products of active pharmaceutical ingredients (APIs) is of major interest for the development and approval of new drugs. Therefore, methodologies for the time-efficient and precise prediction of degrad...
Solvent Selection for Circular Designs - Bridging Process Needs and Sustainability Goals [0.03%]
溶剂的选择以符合循环设计的工艺需求和可持续发展目标为目标
Michael U Luescher,Alessia Valotta,Julien Haber et al.
Michael U Luescher et al.
Pharmaceutical industries play a crucial role in enhancing global health outcomes; however, like many other sectors, they also encounter significant environmental challenges. The extraction of raw materials and the manufacture of active pha...
Bridging Innovation and Efficiency: The Promises and Challenges of Self-Driving Labs as Sustainable Drivers for Chemistry [0.03%]
创新与效率的桥梁：自动驾驶实验室作为化学可持续驱动力的机遇与挑战
Florian A Formica,Edlyn Wu,Lucien Brey et al.
Florian A Formica et al.
Self-driving laboratories (SDLs) are reshaping scientific discovery by combining robotics, artificial intelligence (AI), and data science to automate the full Design-Make-Test-Analyze (DMTA) cycle. This review highlights how SDLs address th...
Ludovic Gremaud,Fabrice Gallou
Ludovic Gremaud
Editorial
Chimia. 2025 Sep 10;79(9):597. DOI:10.2533/chimia.2025.597 2025
Innovation in Route Design, (Bio)Catalysis and Process Development Applied to the Second Generation Synthesis of Sacubitril [0.03%]
应用于沙库必曲特第二代合成的路线设计、（生）催化及工艺开发创新
Florian Kleinbeck
Florian Kleinbeck
Commercial manufacturing processes in the pharmaceutical industry need to address numerous goals, ranging from cost effectiveness over process safety to environmental sustainability. While the design of the synthetic route may commonly be c...
Trace-level Multi-residue Analysis of Pesticides in Soil: Advances, Challenges, and Future Directions [0.03%]
土壤中痕量农药多残留分析：进展、挑战与未来方向
Andrea Rösch,Thomas D Bucheli
Andrea Rösch
Pesticides are frequently applied in large quantities in agriculture, resulting in their widespread presence in agricultural areas. Additionally, processes such as drift and volatilization contribute to their dispersion far beyond treated s...