Advancing Metal-Free Asymmetric Hydrogenation: From FLP Catalyst Design to Synthetic Innovations [0.03%]
从金属自由不对称氢化催化剂设计到合成创新的发展路程
Nikolay V Shcherbakov,Josep Mas-Roselló
Nikolay V Shcherbakov
Asymmetric hydrogenation (AH) is one of the most important transformations in organic synthesis, enabling efficient access to enantioenriched molecular building blocks used in pharmaceuticals, agrochemicals, and fine chemicals. AH is largel...
Chiral Bifunctional Photocatalysts with Aromatic Ketones as Photosensitizers [0.03%]
具有芳香酮光敏剂的手性双功能光催化剂
Giuseppe Zuccarello
Giuseppe Zuccarello
Because the biological activity of a molecule is directly linked to its three-dimensional configuration, the preparation of chiral compounds is a central discipline in synthetic organic chemistry. With the exploitation of photoredox catalys...
Eléonore Moore,Amy E Fraley
Eléonore Moore
Cyclic natural products offer important, unique scaffolds and functionalities for the pharmaceutical industry. They are produced by enzymes catalyzing a wide range of cyclization reactions. This large family of enzymes creates distinctive c...
Ana I Benítez-Mateos
Ana I Benítez-Mateos
Enzymes are emerging as a central element of green chemistry due to their high selectivity, biodegradability, and biocompatibility. However, their application in biotechnology is often limited by their poor stability under non-native condit...
Tailored Compound Specific Carbon Isotopes Analysis in Heritage Science [0.03%]
遗产科学中的定制化化合物特异碳同位素分析法研究
Lionel Rumpf,Edith Sandström,Clémence Iacconi et al.
Lionel Rumpf et al.
Radiocarbon dating has long been a cornerstone of archaeological science, offering a reliable method to determine the age of organic materials. Yet when applied to cultural heritage objects, traditional bulk analysis methods often fall shor...
Minghan Hu
Minghan Hu
At the microscale, robotic intelligence cannot rely on circuits or processors; instead, it must emerge directly from responsive materials. Chemistry provides the means: polymers, catalytic and magnetic materials enable single responsive mec...
Disentangling a Complex Biomolecular World with Single-Molecule Resolution [0.03%]
利用单分子分辨率拨开复杂生物分子世界的面纱
Wenxian Tang,David Fuentenebro Navas,Benjamin Vermeer et al.
Wenxian Tang et al.
Biological systems rely on a complex and precisely controlled mix of biomolecules to sustain life as we know it. In addition to their compositional heterogeneity, individual biomolecules undergo dynamic rearrangements to fulfil their cellul...
Transport, Dynamics, and Phase Behavior of Soft Matter Under Nanoconfinement [0.03%]
软物质纳米限域下的输运、动力学及相行为研究进展
Yang Yao
Yang Yao
Nanoscale confinement strongly alters the behavior of soft matter, from polymer crystallization to lipid self-assembly. In this mini review, we summarize recent progress on how confinement impacts molecular transport, crystallization, dynam...
Beyond the Canonical 20: Peptide Discovery with Non-Canonical Amino Acids [0.03%]
超越标准的20种氨基酸：非标准氨基酸肽发现
Nathalie M Grob
Nathalie M Grob
Amino acids are central to biology as signaling molecules and as the building blocks of peptides and proteins, which represent an expanding class of drugs with vast therapeutic potential. The precise modulation of individual residues in the...
Chemigenetic Approaches for the Development of Fluorescent Biosensors for Biological Imaging [0.03%]
化学遗传学方法开发生物荧光生物传感器用于生物学成像
Elias Dressler,Michelle S Frei
Elias Dressler
Fluorescent biosensors are essential for probing analyte dynamics and enzyme activities with high spatial and temporal resolution in living cells by functional microscopy. Recently hybrid, or so called chemigenetic, biosensors have emerged,...