Takaaki Kubota,Teppei Suzuki,Kan&#x;ichiro Ishiuchi et al.
Takaaki Kubota et al.
Three new Daphniphyllum alkaloids, daphnezomines T-V (1-3), were isolated from the leaves and branches of Daphniphyllum humile (Daphniphyllaceae). The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectrosco...
Deletion of single amino acid E235 affects the structure and lipid interaction of human apolipoprotein A-I C-terminal peptides [0.03%]
切除单个氨基酸E235影响人源清道蛋白A-I的C端多肽结构及与脂类相互作用
Toshitaka Tanaka,Masafumi Tanaka,Makiko Sugiura et al.
Toshitaka Tanaka et al.
The C-terminal domain of apolipoprotein (apo) A-I plays an important role in lipid binding. ApoA-I Nichinan, a naturally occurring human apoA-I variant with a deletion of E235 located in the C-terminus, is associated with low high-density l...
Xiaohua Li,Liangxiong Xu,Ping Wu et al.
Xiaohua Li et al.
Four novel prenylflavonols, macaranones A-D (1-4), were isolated from the leaves of Macaranga sampsonii. Their structures were elucidated on the basis of spectroscopic data. Macaranones C (3) and D (4) represent first two examples of flavon...
Antidiabetogenic constituents from the Thai traditional medicine Cotylelobium melanoxylon [0.03%]
泰国传统草药Cotylelobium melanoxylon中的抗糖尿病成分
Hisashi Matsuda,Yasunobu Asao,Seikou Nakamura et al.
Hisashi Matsuda et al.
The methanolic extracts from the wood and bark of Cotylelobium melanoxylon were found to inhibit plasma glucose elevation after sucrose loading in rats and triglyceride elevation after olive oil loading in mice. A new stilbene dimer, melano...
Interaction of DNA minor groove binder Hoechst 33258 with bovine serum albumin [0.03%]
DNA小沟结合剂Hoechst 33258与牛血清白蛋白的相互作用
Himanshu Ojha,Bhaskar Mohan Murari,Sneh Anand et al.
Himanshu Ojha et al.
Hoechst 33258 belongs to bisbenzimidazole class of molecules having anticancer properties for their ability to inhibit topoisomerase and many other cellular processes. The aim of the present study is to understand the nature of Hoechst 3325...
Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds [0.03%]
烷基对羟基肉桂酸酯及其类似物的合成及对DNA聚合酶α和β抑制活性研究
Katsumi Nishimura,Yukiko Takenaka,Manami Kishi et al.
Katsumi Nishimura et al.
trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases alpha and beta. Among 30 com...
4-Hydroxy-3-methoxymethamphetamine glucuronide as a phase II metabolite of 3,4-methylenedioxymethamphetamine: enzyme-assisted synthesis and involvement of human hepatic uridine 5'-diphosphate-glucuronosyltransferase 2B15 in the glucuronidation [0.03%]
3,4-亚甲基二氧基甲基安非他明的二期代谢产物：4-羟基-3-甲氧甲基麻黄素葡萄糖醛酸酯的酶促合成及其在人肝UDP-葡萄糖醛酸转移酶2B15介导的葡糖醛酸化的参与作用
Takuji Shoda,Kiyoshi Fukuhara,Yukihiro Goda et al.
Takuji Shoda et al.
3,4-Methylenedioxymethamphetamine (MDMA), one of the most popular illicit recreational drugs, is metabolized primarily into 4-hydroxy-3-methoxymethamphetamine (HMMA) by drug-metabolizing enzymes. HMMA is further metabolized by phase II enzy...
Application of hot-melt coating process for designing a lipid based controlled release drug delivery system for highly aqueous soluble drugs [0.03%]
热熔包衣工艺在高水溶性药物的脂质控释递送系统设计中的应用研究
Zdravka Knezevic,Darko Gosak,Marin Hraste et al.
Zdravka Knezevic et al.
Hot-melt coating process (HMCP) was applied to develop a lipid based oral controlled release matrix system (tablet) to deliver highly aqueous soluble drugs using paracetamol as a model drug. Granules prepared from paracetamol and particular...
The influence of water on the stability of lyophilized formulations with inositol and mannitol as excipients [0.03%]
甘油酸和右旋糖作为赋形剂的冷冻干燥制剂中水分对稳定性的影响
Akira Terakita,Hirokazu Matsunaga,Tetsuro Handa
Akira Terakita
The stability of a moisture-sensitive drug in lyophilized products was investigated under conditions with varying water content and temperature using two model formulations: a formulation containing inositol (IF) as the excipient and a form...
Physicochemical characterization and drug release of thermosensitive hydrogels composed of a hyaluronic acid/pluronic f127 graft [0.03%]
由透明质酸/Pluronic F127接枝物组成的热敏水凝胶的理化性质及药物释放性能研究
Shu-Hui Hsu,Yann-Lii Leu,Jiuan-Wen Hu et al.
Shu-Hui Hsu et al.
Pluronic F127 (PF127) is a copolymer which forms thermosensitive hydrogels. Hyaluronic acid (HA) was grafted to PF127 to form a new hydrogel matrix (HP) for delivery of cisplatin and carboplatin. The physicochemical properties and drug deli...