Polypseudorotaxane formation of randomly-pegylated insulin with cyclodextrins: slow release and resistance to enzymatic degradation [0.03%]
随机PEG化胰岛素与环糊精结合的聚合物假轮烷形成：缓慢释放及抗酶降解性
Taishi Higashi,Fumitoshi Hirayama,Shogo Misumi et al.
Taishi Higashi et al.
Pegylation technology has been widely used to improve therapeutic efficacies of protein drugs and a number of selective- or randomly-substituted pegylated proteins are on the market. In this study, we prepared a insulin derivative substitut...
Enhancement of chemically-induced HL-60 cell differentiation by 3,3'-diindolylmethane derivatives [0.03%]
茋类衍生物DIMCl对化学诱导的HL-60细胞分化正向调节作用的研究
Tomomi Noguchi-Yachide,Masashi Tetsuhashi,Hiroshi Aoyama et al.
Tomomi Noguchi-Yachide et al.
3,3'-Diindolylmethane (DIM, 1) and its derivatives have been prepared, and their enhancing effects on chemically-induced HL-60 cell differentiation were analyzed. Among the prepared compounds, IndDIM (12) showed the most potent enhancing ef...
Three minor novel triterpenoids from the leaves of Diospyros kaki [0.03%]
从柿树（Diospyros kaki Thunb.）叶子中分离的三个三萜新骨架化合物
Guang Chen,Zong-Quan Wang,Ji-Ming Jia
Guang Chen
Two novel 18, 19-secoursane triterpenoids, kakisaponin B (1) and kakisaponin C (2), an ursane type 28-nortriterpene, kakidiol (3) and one known triterpenoid rosamultin (4), were isolated from the leaves of Diospyros kaki. The structures of ...
Dan Bi,Xing-Yun Chai,Yue-Lin Song et al.
Dan Bi et al.
Two new bile acids, tauroselocholic acid (1) and tauroansocholic acid (2), a new natural bile acid, cygnocholic acid (3) were respectively isolated from bear bile powder Selenaretos thibetanus CUVIER and bile of geese Anser anser domesticus...
New terpenoids from Isodon sculponeata [0.03%]
Iso香茶菜素_indsobulenosides A 和 B及邻羟基苯甲酰葡萄糖酯_indsobulenoid C 的研究
Fei Wang,Xiang-Mei Li,Ji-Kai Liu
Fei Wang
Two new ent-kaurane diterpene derivatives, sculponeatins N (1) and O (2), and a new A-ring contracted oleanane triterpenoid, sculponeatic acid (5), were isolated from the plant Isodon sculponeata. Their structures were elucidated on the bas...
Guang-Bo Xie,Si-Xiang Zhou,Ya-Nan Lu et al.
Guang-Bo Xie et al.
Ten triterpenoid glycosides, including five new ones (1-5), were isolated from the leaves of Ilex pernyi. The chemical structures of 1-5 were determined on the basis of the chemical and spectroscopic evidence.
Tetsuro Ito,Naohito Abe,Zulfiqar Ali et al.
Tetsuro Ito et al.
Phytochemical investigation of an acetone extract of Upuna borneensis (Dipterocarpaceae) resulted in the isolation of two new resveratrol tetramers, upunaphenols O (1) and P (2). The structures were elucidated by spectroscopic analysis incl...
New bibenzyl derivatives from the tubers of Pleione yunnanensis [0.03%]
云南球茎 Pleione yunnanensis中新倍半萜茋类成分研究
Hai-Ling Dong,Chun-Lan Wang,Shun-Xing Guo et al.
Hai-Ling Dong et al.
Four new bibenzyl derivatives, shancigusins A-D (1-4) and five known bibenzyls (5-9) were isolated from the tubers of Pleione yunnanensis (Orchidaceae). The structures of these compounds were determined by extensive analyses of their spectr...
Interesting nickel-catalyzed 1,2-addition to alpha,beta-unsaturated aldehydes with arylborates [0.03%]
有趣的镍催化α,β-不饱和醛与arylborates的1,2-加成反应
Fumie Sakurai,Kazuhiro Kondo,Toyohiko Aoyama
Fumie Sakurai
Ni-Et-Duphos-catalyzed 1,2-addition of potassium aryltrifluoroborates to alpha,beta-unsaturated aldehydes is described.
Satomi Niwayama,Hanjoung Cho
Satomi Niwayama
A practical large-scale synthesis of monomethyl malonate and monoethyl malonate, which are among the most commonly applied half-esters in organic synthesis, is described, applying the highly efficient selective monohydrolysis of symmetric d...