Steven H Liang,Neil Vasdev
Steven H Liang
The logic of total synthesis transformed a stagnant state of medicinal and synthetic organic chemistry when there was a paucity of methods and reagents to synthesize drug molecules and/or natural products. Molecular imaging by positron emis...
On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials [0.03%]
关于小分子Berberine-INF55（5-硝基-2-苯基吲哚）复合抗菌机制研究
Naveen K Dolla,Chao Chen,Jonah Larkins-Ford et al.
Naveen K Dolla et al.
Berberine-INF55 hybrids are a promising class of antibacterials that combine berberine and the NorA multidrug resistance pump inhibitor INF55 (5-nitro-2-phenylindole) together in one molecule via a chemically stable linkage. Previous studie...
Molecular Characterization of Collagen Hydroxylysine O-Glycosylation by Mass Spectrometry: Current Status [0.03%]
质谱表征胶原羟基赖氨酸O-糖基化修饰的现状
Irina Perdivara,Mitsuo Yamauchi,Kenneth B Tomer
Irina Perdivara
The most abundant proteins in vertebrates - the collagen family proteins - play structural and biological roles in the body. The predominant member, type I collagen, provides tissues and organs with structure and connectivity. This protein ...
An Oxidized Abasic Lesion as an Intramolecular Source of DNA Adducts [0.03%]
一种氧化的无嘌呤/嘧啶碱基位点在DNA加合物形成中的潜在作用
Lirui Guan,Marc M Greenberg
Lirui Guan
5'-(2-Phosphoryl-1,4-dioxobutane) (DOB) is a lesion produced in DNA via a variety of damaging agents. The DOB lesion spontaneously generates cis- and trans-but-2-en-1,4-dial (1) via β-elimination. Cis- and trans-but-2-en-1,4-dial forms exo...
Saliniquinones A-F, New Members of the Highly Cytotoxic Anthraquinone-γ-Pyrones from the Marine Actinomycete Salinispora arenicola [0.03%]
来源于海洋放线菌Salinispora arenicola的新高效抗肿瘤蒽醌-γ-吡喃类化合物_saliquinones A-F
Brian T Murphy,Tadigoppula Narender,Christopher A Kauffman et al.
Brian T Murphy et al.
Six new anthraquinone-γ-pyrones, saliniquinones A-F (1-6), which are related to metabolites of the pluramycin/altromycin class, were isolated from a fermentation broth of the marine actinomycete Salinispora arenicola (strain CNS-325). Thei...
Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase [0.03%]
作为PI3激酶抑制剂的4-亚胺噻唑烷酮的合成与药理学评价
Jo-Anne Pinson,Oleg Schmidt-Kittler,Mark Frazzetto et al.
Jo-Anne Pinson et al.
The thiazolidinedione, compound 1, has previously shown pan-inhibition of the phosphoinositide 3-kinase (PI3K) class I isoforms. We hypothesized the derivatization of the thiazolidinedione core of compound 1 could introduce isoform selectiv...
Chemically Specific Imaging Through Stimulated Raman Photoexcitation and Ultrasound Detection: Minireview [0.03%]
化学特异性拉曼光激发和超声检测成像：述评
Vladislav V Yakovlev,Georgi I Petrov,Hao F Zhang et al.
Vladislav V Yakovlev et al.
A powerful combination of chemically specific Raman excitation and deep tissue ultrasound imaging holds the promise to attain spatially resolved distribution of chemical compounds inside the scattering medium. In this report, an attempt is ...
Tobias Weidner,Joe E Baio,Alexander Mundstock et al.
Tobias Weidner et al.
Thin films of 1,3-diethylbenzimidazol-2-ylidene (BIEt) were fabricated from THF solution on solid gold substrates and characterised by high-resolution X-ray photoelectron and near-edge X-ray absorption fine structure spectroscopy. The surfa...
Progress Towards Simple and Direct Detection of Adenylosuccinate Lyase Deficiency in Human Urine [0.03%]
人类尿液中腺苷磺酸裂解酶缺乏简单直接检测方法的研究进展
Soojin Lim,Mark Lowry,Robert M Strongin
Soojin Lim
A rhodamine based boronic acid linearly responds to increasing 5-aminoimidazole-4-carboxamide riboside (AICAr) concentrations in human urine. This method is thus an advance in detecting adenylosuccinate lyase (ADSL) deficiency as AICAr is a...
N-Heterocyclic Carbene-Promoted Rauhut]Currier Reactions between Vinyl Sulfones and α,β-Unsaturated Aldehydes [0.03%]
咪唑类碳烯促进的烯基硫氧化物与α，β-不饱和醛的Rauhut-Currier反应
Roxanne L Atienza,Karl A Scheidt
Roxanne L Atienza
N-heterocyclic carbenes (NHCs) promote the addition of 1,1-bis(phenylsulfonyl)ethylene to the α-position of α,β-unsaturated aldehydes. The proposed reaction pathway for this Rauhut-Currier-type reaction includes an unusual conjugate addi...