Differential membrane binding of α/β-peptide foldamers: implications for cellular delivery and mitochondrial targeting [0.03%]
α/β-肽折叠体在细胞膜上的不同结合行为：其对细胞递送和线粒体靶向的影响
Tzong-Hsien Lee,James W Checco,Tess Malcolm et al.
Tzong-Hsien Lee et al.
The intrinsic pathway of apoptosis is regulated by the Bcl-2 family of proteins. Inhibition of the anti-apoptotic members represents a strategy to induce apoptotic cell death in cancer cells. We have measured the membrane binding properties...
Jeffrey Y W Mak
Jeffrey Y W Mak
PULCON (Pulse Length Based Concentration Determination) is a powerful, versatile, non-invasive, and accurate technique for measuring solution concentrations during routine NMR spectroscopy. As solutes are quantified directly by their unique...
A theoretical assessment of structure determination of multi-span membrane proteins by oriented sample solid-state NMR spectroscopy [0.03%]
理论评估多跨膜蛋白结构测定的取向样品固态NMR光谱法
Daniel K Weber,Gianluigi Veglia
Daniel K Weber
Oriented sample solid state NMR (OS-ssNMR) spectroscopy allows direct determination of the structure and topology of membrane proteins reconstituted into aligned lipid bilayers. While OS-ssNMR theoretically has no upper size limit, its appl...
John S Albin,Bradley L Pentelute
John S Albin
Organisms from all kingdoms of life have evolved a vast array of peptidic natural products to defend against microbes. These are known collectively as antimicrobial peptides (AMPs) or host defense peptides, reflecting their abilities to not...
On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe [0.03%]
一种标记α-康托克斯毒素的新型方法：荧光染料Cy5修饰的RgIA及其在活体动物中成像α9α10型烟碱乙酰胆碱受体中的应用
Markus Muttenthaler,Simon T Nevin,Marco Inserra et al.
Markus Muttenthaler et al.
In-solution conjugation is the most commonly used strategy to label peptides and proteins with fluorophores. However, lack of site-specific control and high costs of fluorophores are recognised limitations of this approach. Here, we establi...
William C Wimley,Kalina Hristova
William C Wimley
Peptide-induced permeabilization of lipid vesicles has been measured for decades and has provided many insights into the sequence-structure-function relationships of membrane-active peptides. However, researchers in the field have noted tha...
Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2) [0.03%]
生物活性果蝇胰岛素样肽2(DILP2)的全固相合成法
Feng Lin,Mohammed Akhter Hossain,Stephanie Post et al.
Feng Lin et al.
In the fruit fly Drosophila melanogaster, there are eight insulin-like peptides (DILPs) with DILPs 1-7 interacting with a sole insulin-like receptor tyrosine kinase (DInR) while DILP8 interacts with a single G protein-coupled receptor (GPCR...
Photoinduced Cycloadditions in the Diversity-Oriented Synthesis Toolbox: Increasing Complexity with Straightforward Postphotochemical Modifications [0.03%]
多样性导向合成中的光诱导环加成反应：通过简单的光化学后修饰增加复杂性
Weston J Umstead,Olga A Mukhina,N N Bhuvan Kumar et al.
Weston J Umstead et al.
Rapid growth of complexity and unprecedented molecular architectures are realized via the excited-state intramolecular proton transfer (ESIPT) in o-acylamidobenzaldehydes and ketones followed by [4+2] or [4+4] cycloadditions with subsequent...
Synthetic Models for Nickel-Iron Hydrogenase Featuring Redox-Active Ligands [0.03%]
含氧化还原活性配体的镍铁氢酶合成模型
David Schilter,Danielle L Gray,Amy L Fuller et al.
David Schilter et al.
The nickel-iron hydrogenase enzymes efficiently and reversibly interconvert protons, electrons, and dihydrogen. These redox proteins feature iron-sulfur clusters that relay electrons to and from their active sites. Reported here are synthet...
Milena Kolpaczynska,Christopher A DeRosa,William A Morris et al.
Milena Kolpaczynska et al.
Difluoroboron β-diketonates have impressive optical properties in both solution and the solid state. In particular, both fluorescence and room-temperature phosphorescence are present when the dyes are confined to a rigid matrix, such as po...