Nikolaos Scarmeas,Jason Brandt,Deborah Blacker et al.
Nikolaos Scarmeas et al.
Background: Disruptive behavior is common in Alzheimer disease (AD). There are conflicting reports regarding its ability to predict cognitive decline, functional decline, institutionalization, and mortality. ...
Multicenter Study
Archives of neurology. 2007 Dec;64(12):1755-61. DOI:10.1001/archneur.64.12.1755 2007
Elizabeth P Helzner,Nikolaos Scarmeas,Stephanie Cosentino et al.
Elizabeth P Helzner et al.
Background: High rates of leisure activity have been associated with reduced risk of Alzheimer disease (AD). Objective: To determine wh...
Variability of age at onset in siblings with familial Alzheimer disease [0.03%]
家族性阿尔茨海默病患者中发病年龄的变异性
Estrella Gómez-Tortosa,M Sagrario Barquero,Manuel Barón et al.
Estrella Gómez-Tortosa et al.
Background: Variability of age at onset (AO) of Alzheimer disease (AD) among members of the same family is important as a biological clue and because of its clinical effects. ...
Christiane Reitz,Ming-Xin Tang,Jennifer Manly et al.
Christiane Reitz et al.
Objective: To explore whether hypertension is associated with the risk of mild cognitive impairment (MCI), an intermediate stage of dementia, because there are conflicting data relating hypertension to the risk of Alzheim...
Christian Amdahl,Espen H Alseth,Nils E Gilhus et al.
Christian Amdahl et al.
Background: Relevant genetic markers for myasthenia gravis (MG) include tumor necrosis factors alpha and beta, Fcgamma receptor IIa, and interleukin 10. The corresponding gene products are thought to be involved in MG pat...
Heart valve regurgitation, pergolide use, and parkinson disease: an observational study and meta-analysis [0.03%]
心脏瓣膜反流、培高利特使用及帕金森病：一项观察性研究和荟萃分析
Jean-Christophe Corvol,Jean-Baptiste Anzouan-Kacou,Elodie Fauveau et al.
Jean-Christophe Corvol et al.
Objective: To investigate the prevalence and risk factors of heart valve disease in patients having PD treated with pergolide. Design: ...
Mehdi Tafti,Norbert B Ghyselinck
Mehdi Tafti
Vitamin A is necessary for normal embryonic development, but its role in the adult brain is poorly understood. Vitamin A derivatives, retinoids, are involved in a complex signaling pathway that regulates gene expression and, in the central ...
Mayowa O Owolabi,James H Bower,Adesola Ogunniyi
Mayowa O Owolabi
Although neurology originated in Africa, there is little modern African contribution to the advancement of knowledge in this field. We present the African neurologic service and scientific productivity indices and suggest a development plan...
The wind of change [0.03%]
变革风起
Johan A Aarli
Johan A Aarli
Combination therapy with interferon beta-1a and doxycycline in multiple sclerosis: an open-label trial [0.03%]
干扰素β-1a与多西环素联合治疗多发性硬化症的开放试验
Alireza Minagar,J Steven Alexander,Robert N Schwendimann et al.
Alireza Minagar et al.
Objective: To evaluate the efficacy, safety, and tolerability of combination therapy with intramuscular interferon beta-1a and oral doxycycline, a potent inhibitor of matrix metalloproteinases, in patients with relapsing-...
Clinical Trial
Archives of neurology. 2008 Feb;65(2):199-204. DOI:10.1001/archneurol.2007.41 2008