Increased frequency of learning disability in patients with primary progressive aphasia and their first-degree relatives [0.03%]
原发进行性失语及其一级亲属中学习困难更常见
Emily Rogalski,Nancy Johnson,Sandra Weintraub et al.
Emily Rogalski et al.
Background: Although risk factors for Alzheimer disease have been well studied, much less is known about risk factors for primary progressive aphasia (PPA). ...
Comparative Study
Archives of neurology. 2008 Feb;65(2):244-8. DOI:10.1001/archneurol.2007.34 2008
Voxel-based assessment of differences in damage and distribution of white matter lesions between patients with primary progressive and relapsing-remitting multiple sclerosis [0.03%]
基于体素的评估原发进展型和复发缓解型多发性硬化患者损伤及白质病变分布差异的方法
Carol Di Perri,Marco Battaglini,Maria L Stromillo et al.
Carol Di Perri et al.
Background: Several studies have reported lower focal demyelination and inflammatory activity in primary progressive multiple sclerosis (PPMS) than in relapsing-remitting MS (RRMS). However, very little is known about pos...
Comparative Study
Archives of neurology. 2008 Feb;65(2):236-43. DOI:10.1001/archneurol.2007.51 2008
Specificity and correlation with disease activity of cerebrospinal fluid osteopontin levels in patients with multiple sclerosis [0.03%]
多发性硬化患者脑脊液骨桥蛋白水平的特异性及其与疾病活动性的相关性
Soheli A Chowdhury,Jerry Lin,Saud A Sadiq
Soheli A Chowdhury
Background: Despite recent advances in therapy that have improved the overall disease course in multiple sclerosis (MS), the prognosis at the outset remains unpredictable. ...
Diederik van de Beek,Walter Kremers,Richard C Daly et al.
Diederik van de Beek et al.
Objective: To study neurologic complications after heart transplant. Design: Retrospective cohort study. ...
Status epilepticus without an underlying cause and risk of death: a population-based study [0.03%]
一项基于人口的科学研究：无病因难治性癫痫持续状态与死亡风险的关系
Giancarlo Logroscino,Dale C Hesdorffer,Gregory Cascino et al.
Giancarlo Logroscino et al.
Objective: To determine the independent effect of status epilepticus (SE) on risk of death. Design: Retrospective cohort study. The inc...
Natural course and pathogenesis of transient focal neurologic symptoms during pregnancy [0.03%]
孕期一过性局灶性神经症状的自然进程及发病机制
Anatoly Liberman,Dimitrios Karussis,Tamir Ben-Hur et al.
Anatoly Liberman et al.
Objectives: To determine the pathogenesis and course of transient focal neurologic symptoms in pregnant women and to identify prognostic variables that will enable targeted workup. ...
Christopher H Gibbons,Steven A Vernino,Roy Freeman
Christopher H Gibbons
Background: Autoimmune autonomic ganglionopathy is a disorder defined by antibodies to the nicotinic acetylcholine receptor of the autonomic ganglia. Patients present with symptoms of autonomic failure, including syncope,...
Vivien H Lee,Eelco F M Wijdicks,Edward M Manno et al.
Vivien H Lee et al.
Background: Reversible posterior leukoencephalopathy syndrome (RPLS) is characterized by neuroimaging findings of reversible vasogenic subcortical edema without infarction. The clinical syndrome of RPLS typically involves...
Effect of low concentrations of apomorphine on parkinsonism in a randomized, placebo-controlled, crossover study [0.03%]
一项随机双盲交叉对照研究中低剂量阿朴吗啡对帕金森病的影响
Steven A Gunzler,Caroline Koudelka,Nichole E Carlson et al.
Steven A Gunzler et al.
Objective: To determine whether low concentrations of a dopamine agonist worsen parkinsonism, which would suggest that activation of presynaptic dopamine autoreceptors causes a super-off state. ...
Randomized Controlled Trial
Archives of neurology. 2008 Feb;65(2):193-8. DOI:10.1001/archneurol.2007.58 2008
Claudio Soto,Lisbell D Estrada
Claudio Soto
A key molecular pathway implicated in diverse neurodegenerative diseases is the misfolding, aggregation, and accumulation of proteins in the brain. Compelling evidence strongly supports the hypothesis that accumulation of misfolded proteins...