NEW SPIROHYDANTOIN DERIVATIVES - SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDY [0.03%]
新型螺杂环丁酰脲衍生物的合成、药理评价及分子建模研究
Anna Czopek,Agnieszka Zagorska,Marcin Kolaczkowski et al.
Anna Czopek et al.
A series of new arylpiperazinylpropyl derivatives of 8/6-phenyl-1,3-diazaspiro[4.5]decan-2,4-dione and spiro[imidazolidine-4,1'-indene/naphthalene]-2,5-dione was synthesized and their affinity was evaluated toward serotonin 5-HTIA, 5-HT2A, ...
ANTI-ADHESIVE AND ANTI-BIOFILM ACTIVITIES IN VITRO OF LINEZOLID, VANCOMYCIN, TIGECYCLINE AND DAPTOMYCIN AGAINST STAPHYLOCOCCUS HAEMOLYTICUS [0.03%]
利奈唑胺、万古霉素、替加环素和达托霉素对溶血葡萄球菌的体外抗粘附和抗生物被膜活性作用研究
Marek Juda,Pawel Helon,Anna Malm
Marek Juda
Biofilm may be formed on wide variety of surfaces, including indwelling medical devices, leading to several infectious diseases, e.g., bacteremia and sepsis. The most,important pathogens related with infections associated with medical devic...
Comparative Study
Acta poloniae pharmaceutica. 2016 Nov;73(6):1539-1543. DOI: 2016
INACTIVATION OF ALDEHYDE DEHYDROGENASE BY NITROGLYCERIN IN THE PRESENCE AND ABSENCE OF LIPOIC ACID AND DIHYDROLIPOIC ACID. IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO [0.03%]
在有无和无左旋肉碱及左旋肉碱的情况下的硝酸甘油对醛脱氢酶的失活。这对体内和体外使用左旋肉碱的不同效果的问题的意义
Anna Bilska-Wilkosz,Magdalena Gorny,Magdalena Dudek et al.
Anna Bilska-Wilkosz et al.
Lipoic acid (LA-(SS), LA) and its reduced form - dihydrolipoic acid DHLA-(SH)2, DHLA) are synthesized mainly in the mammalian liver. In this study, we investigated in viti the inactivation of yeast aldehyde dehydrogenase (ALDH) by nitroglyc...
EFFECT OF COLLA CORNUS CERVI COMBINED WITH LV-MEDIATED BMP7 TRANSFECTED BMSCs ON ANFH IN RATS [0.03%]
鹿角胶联合携带BMP7基因的骨髓间充质干细胞治疗对大鼠股骨头缺血性坏死的影响
Ping Wang,Bin Shi,Zhi-Hui Gao et al.
Ping Wang et al.
In the present study, we investigated the combined effect of Colla Comus Cervi (CCC) and BMP7-overexpressing bone marrow-derived mesenchymal stem cells (BMSCs) on osteogenic induction and the treatment of avascular necrosis of the femoral h...
IN VITRO ANTIFUNGAL ACTIVITY OF 2,4-DIHYDROXY-N-(3-THIOXO-3H- 1,2,4-DITHIAZOL-5-YL)BENZENECARBOTHIOAMIDE [0.03%]
2,4-二羟基-N-(3-硫代-3H-1,2,4-二噻唑-5-基)苯甲酰胺的体外抗真菌活性
Cecylia Lukaszuk,Elzbieta Krajewska-Kulak,Andrzej Niewiadomy et al.
Cecylia Lukaszuk et al.
An increase in infections due to non albicans species of Candida has been observed in the recent years. The aims of this study were to determine the antifungal activity of 2,4-dihydroxy-N-(3-thioxo-3H-l1,2,4-dithiazol-5-yl)benzenecarbothioa...
Renata Francik,Natalia Szkaradek,Dorota Zelaszczyk et al.
Renata Francik et al.
Certain xanthone derivatives, such as these present in mangosteen fruits, show strong antioxidant activity. On the other hand, evidences accumulated that oxidative stress is involved in epileptogenesis. Therefore, the aim of the present stu...
Comparative Study
Acta poloniae pharmaceutica. 2016 Nov;73(6):1505-1509. DOI: 2016
HPLC-UV ASSAY OF IMATINIB IN HUMAN PLASMA OPTIMIZED FOR BIOEQUIVALENCE STUDIES [0.03%]
用于生物等效性研究的人血浆中伊马替尼的HPLC-UV测定条件的优化
Michal Kaza,Edyta Piorkowska,Monika Filist et al.
Michal Kaza et al.
lmatimb is an anticancer drug approved for the treatment of a number of cancers, mostly used in chronic myeloid leukemia. Numerous bioanalytical methods using high performance liquid chromatography coupled to ultraviolet detection point at ...
ENVIRONMENTALLY FRIENDLY LC/MS DETERMINATION OF EPLERENONE IN HUMAN PLASMA [0.03%]
用于人血浆中厄利孕酮分析的高效液相色谱-串联质谱法测定及相关代谢产物的形成研究
Katarzyna Bus-Kwasnik,Monika Filist,Piotr J Rudzki
Katarzyna Bus-Kwasnik
Eplerenone (EPL), a selective aldosterone receptor antagonist, is indicated in the treatment of chronic heart failure and hypertension. It is hard to find a green assay among a few published methods for its determination in human plasma or ...
RP-HPLC ANALYSIS OF ACIDIC AND BASIC DRUGS IN SYSTEMS WITH DIETHYLAMINE AS ELUENTS ADDITIVE [0.03%]
二乙胺为流动相添加剂的酸性和碱性药物的手性HPLC分析研究英文名称：RP-HPLC ANALYSIS OF ACIDIC AND BASIC DRUGS IN SYSTEMS WITH DIETHYLAMINE AS ELUENTS ADDITIVE
Anna Petruczynik,Karol Wroblewski,Szymon Strozek et al.
Anna Petruczynik et al.
The chromatographic behavior of some basic and acidic drugs was studied on Cl 8, Phenyl-Hexyl and Polar RP columns with methanol or acetonitrile as organic modifiers of aqueous mobile phases containing addition of diethylamine. Diethylamine...
Comparative Study
Acta poloniae pharmaceutica. 2016 Nov;73(6):1475-1485. DOI: 2016
IDENTIFICATION AND DETERMINATION OF RUPATADINE AND FEXOFENADINE BY DENSITOMETRIC METHOD [0.03%]
密度测定法鉴定和测定卢帕他定和非索非那定
Krystyna Czerwinska,Elzbieta Wyszomirska,Elzbieta Kublin et al.
Krystyna Czerwinska et al.
Simple, precise and accurate densitometric methods were developed for the determination of two antihistamine drugs. rupatadine and fexofenadine. Silica gel 60 F₂₅₄ HPTLC plates were used as stationary phase, while mixtures of acetonitril...