Evaluation of the expression of metalloproteinases 2 and 9 and their tissue inhibitors in colon cancer cells treated with phytic acid [0.03%]
植酸对结肠癌细胞金属蛋白酶2和9及其组织抑制剂表达的影响评价研究
Małgorzata Kapral,Joanna Wawszczyk,Magdalena Jurzak et al.
Małgorzata Kapral et al.
Matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9) belong to a zinc dependent family of enzymes that degrade components of extracellular matrix. One postulated mechanism by which inositol hexaphosphate (phytic acid, IP6), an ubiquitous plant...
Possible role of HSP60 in synergistic action of anthracyclines and sulindac in HeLa cells [0.03%]
热休克蛋白60可能在蒽环类药物和索林达可在HeLa细胞中的协同作用中起一定作用
Beata M Gruber,Jolanta Krzysztoń-Russjan,Irena Bubko et al.
Beata M Gruber et al.
As was observed in the earlier studies, doxorubicin (DOX) induced apoptosis in HeLa cells and that effect was potentiated significantly by sulindac (SUL). The aim of the current work was to study the effects of DOX and SUL on HSP60, HSF1 an...
Salivary aldehyde dehydrogenase activity--influence of drugs intake, preliminary research [0.03%]
唾液醛脱氢酶活性-药物摄入的影响-初步研究
Joanna Giebułtowicz,Piotr Wroczyński,Jacek Wierzchowski
Joanna Giebułtowicz
The salivary aldehyde dehydrogenase (ALDH3A1) oxidizes mainly aromatic and long chain aliphatic aldehydes. This enzyme protects organisms from aldehydes originating from food and air pollution, and can also be an important factor in chemica...
The effect of a novel dinuclear platinum complex with berenil and 2-picoline ligands on growth of human breast cancer cells [0.03%]
一种含berenil和2-吡啶
Krzysztof Bielawski,Anna Bielawska,Bozena Popławska et al.
Krzysztof Bielawski et al.
Evaluation of the cytotoxicity of a novel dinuclear platinum(II) complex of formula Pt2(2-picoline)4(berenil)2 employing a MTT assay and inhibition of [3H]thymidine incorporation into DNA in both MDA-MB-231 and MCF-7 breast cancer cells dem...
Comparative Study
Acta poloniae pharmaceutica. 2010 Nov-Dec;67(6):609-14. DOI: 2010
Use of hyphenated LC-MS/MS technique for characterization of impurity profile of quetiapine during drug development [0.03%]
喹硫平研发过程中应用液相色谱-串联质谱联用技术表征杂质概况
Elzbieta U Stolarczyk,Andrzej Kutner
Elzbieta U Stolarczyk
As a part of an integrated quality concept in drug development, the multidimensional evaluation of impurity profiles by LC-MS/MS is presented for quetiapine--an active pharmaceutical ingredient (API). LC-UV is commonly employed for the dete...
Determination of impurities in medical products containing metformin hydrochloride [0.03%]
盐酸二甲双胍制剂中的杂质鉴定
Gabriela Kłaczkow,Elzbieta L Anuszewska
Gabriela Kłaczkow
The object of this study was to present a high-performance liquid chromatography (HPLC) method allowing to identify and quantify the impurities in medical products in which the only active substance is metformin hydrochloride. Metformin (di...
Determination of total hypericins in St. John's wort and herbal medicinal products [0.03%]
定量分析圣约翰草及其复方制剂中的超氧阴离子清除剂总量
Małgorzata Anyzewska,Anna Kowalczuk,Anna Łozak et al.
Małgorzata Anyzewska et al.
The work aimed to determine the levels of hypericins expressed as hypericin in the herbal substance of St. John's wort, in capsules and tablets containing the extract of St. John's wort, tablets containing powdered herb and in tincture and ...
Comparative Study
Acta poloniae pharmaceutica. 2010 Nov-Dec;67(6):586-92. DOI: 2010
Teresa Brodniewicz,Grzegorz Grynkiewicz
Teresa Brodniewicz
Life sciences provide reasonably sound prognosis for a number and nature of therapeutic targets on which drug design could be based, and search for new chemical entities--future new drugs, is now more than ever based on scientific principle...
Synthesis and in vivo anticonvulsant evaluation of 2-chloroquinolinyl hydrazone derivatives [0.03%]
2-氯喹啉基腙衍生物的合成及其抗惊厥活性评价
Suresh Kumar,Sandhya Bawa,Sushma Drabu et al.
Suresh Kumar et al.
New cinnamyl ester and polyalcohol derivative from the rhizomes of Curcuma oligantha var. oligantha [0.03%]
来自大地瓜根茎的新香豆素酯和多元醇衍生物
Shamim Ahmad,Mohammed Ali,Shahid H Ansari
Shamim Ahmad