H Tchórzewski
H Tchórzewski
TNF alpha gen is localised in macrophages, granulocytes, T lymphocytes, astrocytes, NK cells. Virus and bacteria superantigens are main potent inducers of TNF alpha production. TNF alpha activate nuclear transcription factors and is respons...
[Circulating cell differentiation antigens as markers of activity in lymphoproliferative diseases] [0.03%]
循环细胞分化抗原作为淋巴增殖性疾病的活性标志物
I Frydecka
I Frydecka
The presence of soluble differentiation antigens has been recently shown in the sera of healthy subjects and in different pathological disorders. These soluble antigens represent truncated froms of membrane receptors that lack transmembrane...
[Molecular mechanisms of regulating human erythropoiesis--theoretic basis--new treatment strategies] [0.03%]
人类促红细胞生成调控的分子机制及其理论基础和新的治疗策略
M Z Ratajczak
M Z Ratajczak
In this paper the regulation of erythropoiesis is reviewed. The production of red blood cells is discussed at the levels of the genes regulating cell proliferation, the signal transduction proteins, and the stimulatory and inhibitory cytoki...
C Radzikowski,E Pajtasz-Piasecka,H Glazman-Kuśnierczyk
C Radzikowski
The attempts to augment the immune responses in patients with solid tumors have been undertaken since long time ago. Recognition of the nature and biologic functions of cytokines and their receptors was the turning point in the studies on p...
A Chybicka
A Chybicka
Interleukins are the family of growth factors with a wide range of biological activities, which plays a major role in every immunological challenge, cancer defence, acute phase response and inflammation. Their functions are used in therapy ...
[Molecular basis of chronic granulocytic leukemia: from test-tube to patient] [0.03%]
[慢性粒细胞白血病的分子基础：从试验管到病人]
T Skórski
T Skórski
BCR/ABL tyrosine kinases are encoded by hybrid oncogene bcr/abl which is a result of t(9;22) reciprocal translocation. Bcr/abl oncogene is located on Philadelphia chromosome which is detectable in hematopoietic cells of more than 95% of pat...
S Kotlarek-Haus
S Kotlarek-Haus
Undesirable side-effects of some cytokines (including haematopoietic growth (factors) were overviewed. Effects of the secondary release of proinflammatory cytokines stimulation were discussed as well as means of overcoming them.
[Use of hematopoietic growth factors in nonmalignant neutropenias in adults] [0.03%]
造血生长因子用于成人非恶性中性粒细胞减少症患者的研究进展
L Konopka
L Konopka
The results of clinical trials suggest that human hematopoietic factors are very usefull in overcoming neutropenia. Particularly, the great clinical benefit after G-CSF, GM-CSF therapy is observed in different types of neutropenia (cyclic, ...
[Recombinant human tumor necrosis factor alpha (TNF): preclinical studies and results of early clinical trials] [0.03%]
重组人肿瘤坏死因子α(TNF)的实验研究和临床初步试验结果
A Płuzańska
A Płuzańska
The direct cytostatic and cytotoxic effect of recombinant human TNF alpha on human tumor xenografts encourages further clinical investigation. The most commonly observed toxicities (even after low doses), include constitutional symptoms, su...
A Hellmann
A Hellmann
Interleukin 2 (IL-2) is a cytokine which activates cytotoxic cells and stimulates T suppressor cells and may play a role in the treatment of neoplastic disorders. The majority of clinical trials were performed in renal carcinoma and melanom...