Paradigm shifting vaccines: prophylactic vaccines against latent varicella-zoster virus infection and against HPV-associated cancer [0.03%]
划时代的疫苗:潜伏性水痘-带状疱疹病毒预防性疫苗和人乳头瘤病毒相关癌症疫苗
Ian H Frazer,Myron J Levin
Ian H Frazer
We compare the design, mechanism of action, and clinical efficacy of two recently licensed paradigm shifting vaccines. Zostavax is the first vaccine licensed to prevent disease in patients already infected with a pathogen, and is contrasted...
Anna-Barbara Moscicki
Anna-Barbara Moscicki
G Assmann,K Sotlar
G Assmann
About 7-8% of all human cancers are thought to be related to infections with high-risk (HR) human papilloma virus (HPV). Besides cervical cancer, especially squamous cell carcinomas of the anogenital and oropharyngeal regions are associated...
Aimée R Kreimer,Anil K Chaturvedi
Aimée R Kreimer
It is not known whether a human papillomavirus (HPV)-induced oropharyngeal precancerous lesion could be identified by screening with a pap test equivalent or whether one even exists. In this issue of the journal (beginning on page 1378), Fa...
[HPV-associated head and neck cancer. The basics of molecular and translational research] [0.03%]
人乳头瘤病毒相关的头颈部肿瘤:分子及转化研究基础
C Wittekindt,S Wagner,J P Klussmann
C Wittekindt
Translational research refers to the interfaces between preclinical research and targeted short- and medium-term developments through to clinical standards. There are two distinct groups of oropharyngeal malignancies: those caused by tobacc...
The epidemic of HPV-associated oropharyngeal cancer is here: is it time to change our treatment paradigms? [0.03%]
与HPV相关的口咽癌流行病来了:是否到了改变治疗理念的时候了?
Erich M Sturgis,K Kian Ang
Erich M Sturgis
Although relatively uncommon, oropharyngeal cancers are increasing in incidence despite declining prevalence of smoking and in direct opposition to a decreasing incidence of all other head and neck cancers. An epidemic of human papillomavir...
L Feller,R A G Khammissa,N H Wood et al.
L Feller et al.
Human papillomavirus (HPV) is strictly epitheliotropic, infecting stratified squamous cutaneous and mucosal epithelial cells. Oral HPV infection may be subclinical or putatively associated with benign or malignant oral neoplasms. The benign...
The influence of HPV-associated p16-expression on accelerated fractionated radiotherapy in head and neck cancer: evaluation of the randomised DAHANCA 6&7 trial [0.03%]
HPV相关p16表达对头颈部癌症加速分割放射治疗的影响:DAHANCA 6&7 随机试验的评估
Pernille Lassen,Jesper G Eriksen,Annelise Krogdahl et al.
Pernille Lassen et al.
Background and purpose: Tumour HPV-positivity is a favourable prognostic factor in the radiotherapy of HNSCC, but the optimal radiotherapy regimen for HPV-positive HNSCC is not yet defined. Reducing overall treatment time...
Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers [0.03%]
1982至2005年期间澳大利亚头颈癌的发病情况显示,可能与HPV有关的口咽癌发病率上升
J S Hocking,A Stein,E L Conway et al.
J S Hocking et al.
Background: Although tobacco- and alcohol-associated head and neck cancers are declining in the developed world, potentially human papillomavirus (HPV)-associated oropharnygeal cancers are increasing. ...
Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer [0.03%]
Fanconi贫血症DNA损伤反应途径缺陷可增加HPV相关头颈癌易感性
Jung Wook Park,Henry C Pitot,Katerina Strati et al.
Jung Wook Park et al.
Patients with the rare genetic disease, Fanconi anemia (FA), are highly susceptible to squamous cell carcinomas arising at multiple anatomic sites including the head and neck region. Human papillomaviruses (HPVs), particularly HPV16, are as...
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