Epigenetic modulation of signal transduction pathways in HPV-associated HNSCC [0.03%]
人乳头瘤病毒相关性头颈鳞癌中表观遗传调控的信号转导通路研究进展
Maria J Worsham,Kang Mei Chen,Tamer Ghanem et al.
Maria J Worsham et al.
Objective: Human papilloma virus (HPV) positive and HPV negative head and neck squamous cell cancer (HNSCC) are biologically distinct with a prognostic advantage for HPV positive patients compared to HPV negative cases. D...
Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma [0.03%]
与HPV有关的口咽癌中的潜在预后miRNA
Angela B Y Hui,Alice Lin,Wei Xu et al.
Angela B Y Hui et al.
Purpose: Deregulation of miRNAs is associated with almost all human malignancies. Human papillomavirus (HPV)-associated oropharyngeal carcinoma (OPC) has a significantly more favorable outcome compared with HPV-negative O...
MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers [0.03%]
miRNA变异可增加从未吸烟者的口腔咽喉部HPV相关鳞状细胞癌风险
Xicheng Song,Erich M Sturgis,Jun Liu et al.
Xicheng Song et al.
Background: Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). In addition, microRNAs affect all facets of the immune/...
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma [0.03%]
细胞学在HPV相关头颈部癌的诊断和治疗中的作用
Jeffrey F Krane
Jeffrey F Krane
Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) accounts for up to 25% of all HNSCCs. These tumors largely arise from the oropharynx, particularly the tonsil and base of tongue. The first manifestation of...
Immunotherapy in new pre-clinical models of HPV-associated oral cancers [0.03%]
人乳头瘤病毒相关口腔癌症新前期模型的免疫疗法研究
Francesca Paolini,Silvia Massa,Isabella Manni et al.
Francesca Paolini et al.
Cervical, anal, penile and a sub-set of head and neck (HN) tumors are critical health problems caused by high risk Human Papilloma Viruses (HPVs), like HPV type 16. No specific/effective pharmacological treatments exist. A valid preventive ...
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma [0.03%]
程序性死亡配体1在HPV相关头颈鳞癌中的免疫逃逸作用研究
Sofia Lyford-Pike,Shiwen Peng,Geoffrey D Young et al.
Sofia Lyford-Pike et al.
Human papillomavirus-associated head and neck squamous cell carcinomas (HPV-HNSCC) originate in the tonsils, the major lymphoid organ that orchestrates immunity to oral infections. Despite its location, the virus escapes immune elimination ...
DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia [0.03%]
与肛鳞状上皮瘤变相关的HPV表观遗传调控研究
Jonathan M Hernandez,Erin M Siegel,Bridget Riggs et al.
Jonathan M Hernandez et al.
Background: Changes in host tumor genome DNA methylation patterns are among the molecular alterations associated with HPV-related carcinogenesis. However, there is little known about the epigenetic changes associated spec...
Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies [0.03%]
人乳头瘤病毒16型E6/E7特异性的细胞毒性T淋巴细胞用于治疗与HPV相关的肿瘤的过继免疫疗法
Carlos A Ramos,Neeharika Narala,Gayatri M Vyas et al.
Carlos A Ramos et al.
Vaccines prevent human papillomavirus (HPV)-associated cancer but, although these tumors express foreign, viral antigens (E6 and E7 proteins), they have little benefit in established malignancies, likely due to negative environmental cues t...
The Lower Anogenital Squamous Terminology Standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology [0.03%]
低肛生殖器鳞状上皮HPV相关病变术语标准化项目：病理医师学院和阴道镜及宫颈病理学会共识建议
Teresa M Darragh,Terence J Colgan,J Thomas Cox et al.
Teresa M Darragh et al.
The terminology for human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge ...
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