Conformational Dynamics and Binding Interactions of SARS-CoV-2 Spike Protein Variants: Omicron, XBB.1.9.2, and EG.5 [0.03%]
SARS-CoV-2刺突蛋白变异体（包括Omicron、XBB.1.9.2和EG.5）的构象动力学及结合相互作用
Clauber Henrique Souza da Costa,Camila Auad Beltrão de Freitas,Alberto Monteiro Dos Santos et al.
Clauber Henrique Souza da Costa et al.
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has continuously evolved, generating numerous variants with varying degrees of infectivity and transmissibility. The EG.5 subvariant of SARS-CoV-2 emerged globally in mid-2023 as ...
Computer vision syndrome before and after the SARS-CoV-2 pandemic: New symptom onset and workplace setup of visual display terminals [0.03%]
新冠肺炎大流行前后的计算机视觉综合征：新症状的出现和显示器终端的工作设置
Thomas Behrens,Stephanie Griemsmann,Ingolf Hosbach et al.
Thomas Behrens et al.
Objective: This cross-sectional online survey investigated the associations between the setup of visual display terminals (VDT) and the new onset of symptoms associated with computer-vision syndrome (CVS) after the SARS-C...
Surveillance of severe acute respiratory infections associated with SARS-CoV-2, influenza virus and RSV using ICD-10 codes: a case definition accuracy study across five European countries, 2021 to 2023 [0.03%]
使用ICD-10代码监测与SARS-CoV-2、流感病毒和RSV相关的严重急性呼吸道感染：2021至2023年五国病例定义准确性研究
Miguel Angel Sanchez Ruiz,Diogo Fp Marques,Frederikke Kristensen Lomholt et al.
Miguel Angel Sanchez Ruiz et al.
BACKGROUNDSurveillance of severe acute respiratory infections (SARI) using ICD-10 codes from electronic health records (EHR) lacks consensus on optimal case-defining codes.AIMWe determined codes that maximise sensitivity (Se) and positive p...
Engineering functionally-optimized aptamers against SARS-Cov-2 for blocking spike-ACE2 interaction and aptasensor detection [0.03%]
工程优化SARS-CoV-2功能性适配子以阻断刺突蛋白与ACE2的结合及检测传感
Xiangdong Lai,Weiwei Zhao,Lihua Jiang et al.
Xiangdong Lai et al.
Both the limited research about structure-function relationship and the ill-defined process of conformational dynamic change greatly impede the development of aptamer engineering transformation and seriously restrict the practical applicati...
SARS-CoV-2 Ct values and COVID-19 symptoms in patients with haematological malignancies in South Africa [0.03%]
南非血液系统恶性肿瘤患者中SARS-CoV-2的Ct值和COVID-19症状
Keitumetsi L Sothoane,Sarah A van Blydenstein,Vinitha Philip et al.
Keitumetsi L Sothoane et al.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcriptase polymerase chain reaction (RT-PCR) cycle threshold (Ct) values serve as surrogate markers for estimating viral load. Their use...
Clinical correlation of SARS-CoV-2 wastewater passive sampling in long-term care facilities and wastewater treatment plants [0.03%]
长期照护机构和污水处理厂废水被动采样与SARS-CoV-2的临床相关性研究
William Strike,Alexus Rockward,Blazan Mijatovic et al.
William Strike et al.
Wastewater-based epidemiology (WBE) is a promising tool for improving health outcomes through early detection and cost-effective pathogen surveillance. Long-term care facilities (LTCFs) serve and employ vulnerable populations that may parti...
Electrochemical immunosensor for antibody recognition against SARS-CoV-2 B-cell epitope: impact of RBD mutations on antigen-antibody binding [0.03%]
用于识别SARS-CoV-2 B细胞表位的抗体电化学生物传感器：RBD突变对抗原-抗体结合的影响
Freddy A Nunez,Vivian L de Oliveira,Cesar Remuzgo et al.
Freddy A Nunez et al.
During the SARS-CoV-2 pandemic, the receptor-binding domain (RBD) of the spike protein emerged as a critical target for neutralizing antibodies. While immunoinformatics predicts binding sites, in vitro confirmation of epitope-antibody inter...
Interplay of kidney function and anti-SARS-CoV-2 antibodies in COVID-19 mortality: a prospective cohort study [0.03%]
肾功能与抗SARS-CoV-2抗体在COVID-19死亡率中的交互作用：前瞻性队列研究
Sylvia Mink,Heinz Drexel,Andreas Leiherer et al.
Sylvia Mink et al.
CKD has been recognized as an independent risk factor for severe disease and death in COVID-19. Given the high variability in humoral responses, their general decrease in strength, quality, and durability with age, and the decline of antibo...
Multicenter Study
Scientific reports. 2025 Jul 10;15(1):24978. DOI:10.1038/s41598-025-98788-1 2025
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2 [0.03%]
抑制PIP4K2C可逆转SARS-CoV-2所致的自噬流障碍
Marwah Karim,Manjari Mishra,Chieh-Wen Lo et al.
Marwah Karim et al.
In search for broad-spectrum antivirals, we discover a small molecule inhibitor, RMC-113, that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in human lung organoids. We demonstrate selective inhibition of ...
Author Correction: An RBD-Fc mucosal vaccine provides variant-proof protection against SARS-CoV-2 in mice and hamsters [0.03%]
作者更正：一种RBD-Fc黏膜疫苗可为小鼠和叙利亚金仓鼠提供针对SARS-CoV-2的抗变种保护
Yanjun Zhang,Yan Wu,Meng-Qian Zhang et al.
Yanjun Zhang et al.
Published Erratum
NPJ vaccines. 2025 Jul 10;10(1):150. DOI:10.1038/s41541-025-01210-0 2025
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