David Andras,Stefania D Iancu,Ramona G Cozan et al. David Andras et al.

This study investigates the potential of using surface-enhanced Raman scattering (SERS) serum analysis to assess the response of rectal adenocarcinoma (READ) patients to preoperative radiochemotherapy (RCT). A univariate classification appr...

Tom T Fischer,Kendra K Maaß,Pitithat Puranachot et al. Tom T Fischer et al.

Applying this protocol, cfDNA whole genome profiles were successfully acquired from all liquid biopsy samples (n = 61/61 serum, n = 56/56 CSF, 100%)....Our study underscores the clinical utility of a robust lcWGS-based liquid biopsy assay optimized for low-input samples.

Samaneh Eickelschulte,Anna Starus,David H Murray et al. Samaneh Eickelschulte et al.

Background: Human papillomavirus (HPV) is the primary causative driver of oropharyngeal squamous cell carcinoma (OPSCC). Accurate detection of HPV-DNA is critical for risk stratification and management of OPSCC. However, ...

David O&#x;Reilly,Anthony O&#x;Grady,Conor Hayes et al. David O&#x;Reilly et al.

Background: We report a pilot clinical trial investigating the feasibility of liquid biopsy genotyping (LBG) at the time of radiological suspicion of advanced NSCLC, incorporating a micro-cost model (MCM).

Tong Zhou,Hui Ma,Zhikang Li et al. Tong Zhou et al.

This article provides a comprehensive review of the role and application of exosomes as liquid biopsy markers for early diagnosis of lung cancer, emphasizing their promise in improving patient outcomes through earlier detection and intervention.

Hümeyra Husseini-Wüsthoff,Sabine Riethdorf,Andreas Schneeweiss et al. Hümeyra Husseini-Wüsthoff et al.

In liquid biopsy, detecting and differentiating circulating tumor cells (CTCs) and non-CTCs in metastatic cancer patients' blood samples remains challenging. The current gold standard often involves tedious manual examination of extensive i...

J S Lim,F X Y Kua,T P T Au Yong et al. J S Lim et al.

Cecile Riviere-Cazaux,Terry C Burns Cecile Riviere-Cazaux

Stephen J Bagley,Nike Beaubier,Leonora Balaj et al. Stephen J Bagley et al.

Purpose: Blood-based liquid biopsy has enabled minimally invasive molecular profiling in patients with solid tumors....CSF liquid biopsy is a relatively nascent field, with critical unanswered questions regarding preanalytical variables that may affect assay performance....Through a collaborative and iterative process, we developed a list of key preanalytical variables for cfDNA-based CSF liquid biopsy in patients with primary and metastatic brain malignancies....Results: The Working Group agreed on a recommended list of preanalytical minimum technical data elements, clinical context data elements, and patient context data elements for cfDNA-based CSF liquid biopsy in patients with CNS malignancies....A subset of variables were considered to be of critical priority and are designated as required annotations to submissions of cfDNA-based CSF liquid biopsy sample data into the BLOODPAC Data Commons.

Jens Samol,David Ng,Jonathan Poh et al. Jens Samol et al.

Purpose: To evaluate the performance of a circulating tumor DNA (ctDNA) and circulating tumor RNA (ctRNA) liquid biopsy, LiquidHALLMARK (LHM), compared with tissue next-generation sequencing (NGS) and Guardant360 CDx (G360 ctDNA) liquid biopsy for biomarker detection in metastatic...Treatment outcomes based on liquid biopsy are comparable with those based on tissue NGS. Incorporation of ctRNA into LHM ctDNA improves the diagnostic yield of actionable, tissue NGS-confirmed gene rearrangements.