PD-L1-Targeting Autophagy Modulator to Upregulate MHC-I and Activate Photo-Immunotherapy for Metastatic Tumor Eradication [0.03%]
以PD-L1为靶标的自噬调节物通过上调MHC-I激活光免疫疗法来消除转移性肿瘤
Zhen-Ming Lu,Zi-Wen Qiu,Yan-Mei Li et al.
Zhen-Ming Lu et al.
Breast cancer cells are characterized by heightened autophagy, which impairs tumor-associated antigen presentation and represents a significant barrier to the antitumor immunity. In this study, a PD-L1-targeting autophagy modulator (PFC@CQ)...
Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway [0.03%]
辐射诱导的肿瘤细胞微颗粒通过DNA双链断裂修复通路上调癌细胞MHC-I分子表达
Suke Deng,Jiacheng Wang,Yan Hu et al.
Suke Deng et al.
Radiotherapy (RT) is used for over 50 % of cancer patients and can promote adaptive immunity against tumour antigens. However, the underlying mechanisms remain unclear. Here, we discovered that RT induces the release of irradiated tumour ce...
A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I [0.03%]
编码干扰素-γ的人腺病毒可以转导塔斯马尼亚恶魔面部肿瘤细胞并上调MHC-I类分子的表达
Ahab N Kayigwe,Jocelyn M Darby,A Bruce Lyons et al.
Ahab N Kayigwe et al.
The devil facial tumour disease (DFTD) has led to a massive decline in the wild Tasmanian devil (Sarcophilus harrisii) population. The disease is caused by two independent devil facial tumours (DFT1 and DFT2). These transmissible cancers ha...