Unraveling Homologous Recombination Deficiency in Ovarian Cancer: A Review of Currently Available Testing Platforms [0.03%]
卵巢癌中同源重组缺陷检测平台的研究进展及应用展望
Nicola Marconato,Orazio De Tommasi,Dino Paladin et al.
Nicola Marconato et al.
Challenges related to dynamic tumor evolution and the interpretation of HRD status in recurrent disease settings are also addressed.
Competing Subclones and Fitness Diversity Shape Tumor Evolution Across Cancer Types [0.03%]
竞争的亚克隆和适应度多样性塑造癌症类型间的肿瘤进化路径
Hai Chen,Jingmin Shu,Rekha Mudappathi et al.
Hai Chen et al.
Intratumor heterogeneity arises from ongoing somatic evolution complicating cancer diagnosis, prognosis, and treatment. Here we present TEATIME (es t imating e volution a ry events t hrough s i ngle-ti m epoint s e quencing), a novel comput...
The bile duct and liver cancer: ON-treatment surveillance of tumor evolution and response to systemic treatment (BILLIONSTARS) study [0.03%]
胆管和肝脏癌症：肿瘤发展及全身治疗反应的监控（BILLIONSTARS）研究
Philip Falk,Sofie Olsson Hau,Hedda Jacobsen et al.
Philip Falk et al.
Background: Malignancies of the liver and bile ducts are associated with high recurrence rates after surgery and poor prognosis when disseminated. Medical treatment has been improved in recent years, with chemotherapy, ta...
Observational Study
BMC cancer. 2025 Jun 11;25(1):1017. DOI:10.1186/s12885-025-14429-w 2025
Polystyrene nanoplastics induced transgenerational reproductive toxicity in Caenorhabditis elegans through enhanced DNA damage accompanied by DNA repair inhibition [0.03%]
聚苯乙烯纳米塑料通过增强DNA损伤并抑制DNA修复在秀丽隐杆线虫中诱导跨代生殖毒性
Fanghao Li,Xinran Xu,Zhiyuan Wang et al.
Fanghao Li et al.
Microplastics (MPs) are omnipresent environmental pollutants posing potential impacts on organisms. To explore the transgenerational effects of polystyrene nanoplastics (PS-NPs) and the molecular mechanisms at environmental relevant concent...
Unraveling metastatic timing: insights and challenges from genomic evolution [0.03%]
解开转移性肿瘤的时序：来自基因组进化的一些见解和挑战
Qiu-Luo Liu,Zong-Guang Zhou,Ziqiang Wang et al.
Qiu-Luo Liu et al.
Metastasis, a significant hurdle in cancer treatment, is driven by genetic alterations that shape tumor evolution and dissemination. Traditionally viewed as a late-stage event, recent evidence suggests that metastasis may initiate earlier in tumor progression than previously assumed.
Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients [0.03%]
全面表征中国肺癌患者体细胞突变发生时间以揭示肺腺癌的进化轨迹
Na Qin,Zhoufeng Wang,Xianfeng Xu et al.
Na Qin et al.
Deciphering the timing of driver mutations may lead to insights into tumor evolution that can inform diagnostic and therapeutic approaches for LUAD.
Irradiation-induced increase in nuclear p62 levels contributes to chromosomal fragmentation and chromothripsis [0.03%]
辐照诱导的核p62水平升高导致染色体碎片化和染色体碎裂症
Xiaojuan Yang,Ying Zhou,Buzhe Zhang et al.
Xiaojuan Yang et al.
These chromosomal alterations may play a significant role in tumor evolution and treatment resistance. Our findings suggest that irradiation-induced p62 accumulation is crucial for chromothripsis and may affect nuclear repair processes, impacting chromosomal stability.
Patient-specific prediction of glioblastoma growth via reduced order modeling and neural networks [0.03%]
基于降阶建模和神经网络的胶质母细胞瘤个体化生长预测方法
D Cerrone,D Riccobelli,S Gazzoni et al.
D Cerrone et al.
The framework exploits a diffuse-interface mathematical model to describe the tumor evolution and a reduced-order modeling strategy, relying on proper orthogonal decomposition, trained on synthetic data derived from patient-specific brain anatomies reconstructed from magnetic resonance imaging and diffusion...A neural network surrogate learns the inverse mapping from tumor evolution to model parameters, achieving significant computational speed-up while preserving high accuracy.
Monitoring Abundance and Activity of Electrochemically Inactive Protein in a Single Cell by an Atomically Precise Metal Cluster-Based Electrochemical Sensor [0.03%]
基于原子级金属团簇的电化学传感器单细胞内非原位蛋白质丰度及活性监测研究
Ying Han,Cuicui Qiu,Fuping Gao et al.
Ying Han et al.
The analysis of tumor metastasis-associated proteins is of vital importance for monitoring tumor evolution and evaluating therapeutic outcomes of protein-targeted drugs.
Characterization of Extrachromosomal Circular DNA in Primary and Cisplatin-Resistant High-Grade Serous Ovarian Cancer [0.03%]
高_grade浆液性卵巢癌细胞系中细胞质 circular DNA的特征分析
Youya Wang,He Li,Qinglan Li et al.
Youya Wang et al.
Extrachromosomal circular DNA (eccDNA) has emerged as a critical factor in tumor evolution and drug resistance. However, the specific contribution of eccDNA to cisplatin resistance in HGSOC remains unclear.
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