Re-Evaluating Recurrent Events in Heart Failure Trials: Patterns, Prognostic Implications, and Analytical Improvements [0.03%]
心力衰竭试验中反复发生事件的再评价：模式、预后意义和分析改进
Audinga-Dea Hazewinkel,John Gregson,Stuart J Pocock et al.
Audinga-Dea Hazewinkel et al.
Alternative approaches using area under the curve and win ratio methods for the composite of cardiovascular death and all HFHs strengthened the treatment effect. But still, time-to-first event analyses tended to give the strongest evidence.
Long-Acting Factor XI Inhibition and Periprocedural Bleeding: An Analysis From AZALEA-TIMI 71 [0.03%]
长效第十一因子XI抑制与手术前后出血：AZALEA-TIMI 71试验分析结果
Siddharth M Patel,Robert P Giugliano,David A Morrow et al.
Siddharth M Patel et al.
Periprocedural bleeding events were identified as major/CRNM bleeds, as adjudicated by a clinical events committee blinded to treatment assignment, occurring within 30 days after a procedure, and related to the procedure on blinded review.
Randomized Controlled Trial
Journal of the American College of Cardiology. 2025 Jun 17;85(23):2288-2298. DOI:10.1016/j.jacc.2025.04.018 2025
Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Results of an International Multicenter Prospective Registry [0.03%]
慢性血栓栓塞性肺动脉高压患者肺动脉内球囊成形术的疗效：国际多中心前瞻性注册登记研究结果
Irene M Lang,Philippe Brenot,Hélène Bouvaist et al.
Irene M Lang et al.
Main treatment has been pulmonary endarterectomy, a complex surgical procedure removing vascular obstruction. However, at least 40% of patients are not candidates for pulmonary endarterectomy because of technical inoperability, comorbidities, or limited access to surgery....Balloon pulmonary angioplasty (BPA) has emerged as an interventional treatment for these patients.
Combination therapy of rituximab and mycophenolate in patients with systemic sclerosis and primary cardiac involvement refractory to cyclophosphamide: a retrospective exploratory analysis of 10 cases [0.03%]
利妥昔单抗联合霉酚酸酯治疗环磷酰胺疗效不佳的以心脏受累为主SSc患者：10例回顾性分析
El-Baraa Adjailia,Hanna Grasshoff,Susanne Schinke et al.
El-Baraa Adjailia et al.
Despite the high mortality risk, no specific treatment options for cardiac manifestations in systemic sclerosis (SSc) currently exist....We performed a retrospective medical records analysis at our centre to explore the therapeutic effects of a combination therapy with rituximab (RTX) and mycophenolate (MMF) in 10 patients with SSc-related primary cardiac involvement refractory to previous primary treatment with cyclophosphamide (CP).
Beyond the individual: a qualitative case study into the systemic determinants of speaking-up behaviour in multidisciplinary team meetings [0.03%]
超越个体：多学科团队会议中发言行为的系统决定因素定性案例研究
Dimmy van Dongen,Jaco Tresfon,Frank Guldenmund et al.
Dimmy van Dongen et al.
Yet, this is underused, especially during multidisciplinary team meetings (MDTMs), where diverse professionals collaborate to optimise patient treatment plans.
Effectiveness of the BioFire FilmArray for the rapid detection of bloodstream infection in haematological patients with febrile neutropenia (the ONFIRE study): study protocol of a prospective, multicentre observational study at three reference university hospitals in Spain [0.03%]
西班牙三家大学附属医院发热性中性粒细胞减少症患者血液感染的快速检测（ONFIRE研究）前瞻性多中心观察性研究方案：BioFire FilmArray的有效性
Alba Bergas,Guillem Lopez de Egea,Adaia Albasanz-Puig et al.
Alba Bergas et al.
Blood cultures, the current gold standard for the diagnosis of BSI, present two main drawbacks: the prolonged time to results and their low sensitivity, especially if the patient has received antimicrobial treatment before blood extraction.
Observational Study
BMJ open. 2025 Jun 10;15(6):e101040. DOI:10.1136/bmjopen-2025-101040 2025
ARBOR-Telehealth study: an examination of telerehabilitation to improve function and reduce opioid use in persons with chronic low back pain in rural communities - protocol of a pragmatic, individually randomised group treatment trial [0.03%]
ARBOR-远程医疗研究：一种针对农村社区慢性腰背痛患者改善功能和减少阿片类药物使用情况的远程康复治疗方法——务实型个体随机分组治疗试验方案
Richard L Skolasky,Elizabeth Colantuoni,Stephen T Wegener et al.
Richard L Skolasky et al.
Methods and analysis: This prospective, individually randomised group treatment trial will involve primary care clinics serving rural communities on Maryland's Eastern Shore. We will enroll 434 individuals with chronic LBP....Implementation outcomes are acceptability, adoption, feasibility and fidelity of our treatment approach guided by the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework and assessed using surveys, semi-structured interviews and key performance metrics.
Non-randomised prospective clinical trial to improve follow-up adherence, survivorship knowledge and late effects documentation at a childhood cancer clinic in Western Kenya: a study protocol [0.03%]
肯尼亚西部一家儿童癌症诊所改善随访依从性、幸存者知识和晚期效应记录的非随机前瞻性临床试验：一项研究方案
Jesse Lemmen,Susan Mageto,Terry Vik et al.
Jesse Lemmen et al.
Methods and analysis: This non-randomised prospective clinical trial will be performed at a referral hospital in Western Kenya. 100 caregivers of children diagnosed with cancer, who will complete treatment within 2 months, will be enrolled and followed for 24 months after completion
Systemic indocyanine green administration to detect bile leakage after liver surgery: a prospective clinical trial, using historical controls [0.03%]
系统性注射吲哚菁绿检测肝手术后胆漏的临床研究（历史对照）
Takehiko Hanaki,Keisuke Goto,Naruo Tokuyasu et al.
Takehiko Hanaki et al.
Design: This was a prospective clinical trial with historical controls that involved inverse probability of treatment weighting (IPTW) analysis to adjust for potential confounding biases resulting from nonrandomised treatment assignments.
Clinical Trial
BMJ open. 2025 Jun 10;15(6):e097205. DOI:10.1136/bmjopen-2024-097205 2025
Unravelling VEXAS syndrome: shedding light on a recently recognised medical condition [0.03%]
解开VEXAS综合征之谜：一种新认识的医学状况不容小觑
Syeda Sarah Raza,Abdullah Ahmad Orakzai,Ahmed Salman et al.
Syeda Sarah Raza et al.
The discussion explores VEXAS syndrome's multifaceted nature, its association with myelodysplastic syndrome, diagnostic complexities and varied treatment responses. Despite advances, the prognosis remains guarded.
Case Reports
BMJ case reports. 2025 Jun 10;18(6):e263248. DOI:10.1136/bcr-2024-263248 2025
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