A dendritic cell population responsible for transglutaminase 2-mediated gluten antigen presentation in celiac disease [0.03%]
负责介导celiac疾病中组织转谷氨酰胺酶2依赖性免疫反应的树突细胞群
Fu-Chen Yang,Harrison A Besser,Hye Rin Chun et al.
Fu-Chen Yang et al.
In celiac disease (CeD), a gluten-dependent autoimmune disorder, transglutaminase 2 (TG2) deamidates selected glutamine residues in gluten peptides, while HLA-DQ2 presents deamidated antigens to inflammatory T cells. The cellular sources of pathogenic TG2 and DQ2 are unclear.
Transglutaminase 2-mediated glutamine deamidation enhances p21 stability during senescence [0.03%]
转谷氨酰胺酶2介导的谷氨酰胺脱氨作用可通过提高p21稳定性来促进衰老过程中的细胞周期退出
Yi-Wen Liao,Hsi-Hsien Hsieh,Jin-Wei Yeh et al.
Yi-Wen Liao et al.
This study reveals that serpinB2 upregulation activates transglutaminase 2 (TGM2), which selectively deamidates multiple glutamine residues on p21, stabilizing the protein and halting cell proliferation in senescent cells.
Serological analysis of gluten-related antibodies in idiopathic neuropathies and cerebellar ataxia [0.03%]
特发性神经病和小脑共济失调患者的胶质相关自身抗体检测分析
Maxine D Rouvroye,Janna Warendorf,Alexander Vrancken et al.
Maxine D Rouvroye et al.
The aim of the current study was to test the prevalence of tissue transglutaminase 2 (anti-TG2), tissue transglutaminase 6 (anti-TG6), and gliadin antibodies (anti-gliadin) in a large cross-sectional study.
Fibronectin Composition and Transglutaminase 2 Cross-linking Cooperatively Regulate Ovarian Cancer Cell Adhesion in ECM-Mimetic Constructs [0.03%]
基底膜模型中纤维连接蛋白组成和转谷氨酰胺酶2交联合作调节卵巢癌细胞粘附
Ning Yang,Ali Abbaspour,James M Considine et al.
Ning Yang et al.
Moreover, the ECM cross-linking enzyme transglutaminase 2 (TG2) was increased in omental metastases, where it is enzymatically active in the extracellular environment.
Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines [0.03%]
胰腺癌细胞自身的转谷胺酰胺酶-2通过微管依赖性分泌免疫抑制性细胞因子促进T细胞功能障碍
Edmund K Waller,Kiranj Chaudagar
Edmund K Waller
Lahusen et al identify transglutaminase 2 (TGM2) as a critical tumor cell-intrinsic regulator of immune suppression in PDAC.
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance [0.03%]
tgase2核定位可增强胶质母细胞瘤的放射抵抗性
Cuiping Sun,Zhiyong Du,Wenhui Yang et al.
Cuiping Sun et al.
It was observed that transglutaminase 2 (TGM2) plays a pivotal role in enhancing radiation resistance in GBM, facilitating cell proliferation, and promoting DNA damage repair following irradiation.
The Alkaloid Gelsemine Reduces Aβ Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme [0.03%]
黄连素通过靶向转谷氨酰胺酶2减少Aβ肽毒性
Jessica Panes-Fernández,Ana M Marileo,Nicole Espinoza-Rubilar et al.
Jessica Panes-Fernández et al.
Our findings indicate that gelsemine inhibits the activity of transglutaminase 2 (TG2), an enzyme involved in protein cross-linking with emerging roles in Aβ aggregation and neurotoxicity.
Prevalence and Clinical Profile of Celiac Disease in Yemeni Children: A Five-Year Retrospective Study at Al-Sabeen Hospital [0.03%]
也门塞宾恩医院5年回顾性研究中的儿童乳糜泻患病率及临床特征
Shafa A Alsofi,Nasher A Alaghbari,Najla N Al-Sonboli et al.
Shafa A Alsofi et al.
Diagnosis followed the guidelines of the ESPGHAN guidelines, using transglutaminase 2 antibody (tTA-IgA) and endomysial antibody IgA (EMA IgA) levels, with biopsy recommended for tTA-IgA
Muriel C Maurer
Muriel C Maurer
Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves' Orbitopathy [0.03%]
规范和截短型转谷胺酰胺酶-2通过诱导GRAVES眼病中TGF-β1自分泌环驱动纤维化
Xiaoli Bao,Zhihui Xu,Xi Wang et al.
Xiaoli Bao et al.
Purpose: To evaluate the role of transglutaminase 2 (TGM2) in fibroblasts of Graves' orbitopathy (GO) and explore its potential mechanisms in orbital fibrosis.
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