Transcriptome-wide gene-age interaction study and multi-omics comprehensive analysis reveals heterogeneous regulation of NLRC4 during aging on HNSCC prognosis and immune microenvironment [0.03%]
转录组基因年龄交互作用研究及多组学综合分析揭示了NLRC4在衰老过程中对头颈部鳞癌预后和免疫微环境的异质性调控
Ziang Xu,Maojie Xue,Yuqing Yang et al.
Ziang Xu et al.
Our research identified the complex interaction effects among multiple environment and transcriptomic factors, and provided therapeutic target for HNSCC patients.
Vehicle-specific toxicological profiles of tire wear particles: Physiological, microbial, and transcriptomic disruptions in zebrafish induced by light and heavy-duty vehicle emissions [0.03%]
轮胎磨损颗粒的车辆特异性毒理学特征：轻型和重型汽车排放物对斑马鱼生理、微生物和转录组的干扰
Qingxuan Meng,Qianqian Song,Xinrui Meng et al.
Qingxuan Meng et al.
Here, we comprehensively evaluated physiological responses, gut microbiota alterations, and liver transcriptomic changes in zebrafish exposed to HTWPs and LTWPs. Scanning electron microscopy (SEM) analysis revealed that HTWPs exhibit rougher surfaces and sharper edges compared to LTWPs.
Targeting IL-33 to Suppress Ferroptosis and Alleviate Inflammation in Asthma Exacerbations [0.03%]
靶向IL-33抑制哮喘加重的铁死亡和炎症
Yuhuan Liu,Lianhua Jin,Li Peng et al.
Yuhuan Liu et al.
Through comprehensive transcriptomic and proteomic analyses, IL-33 and GPX4 emerged as crucial regulators in this intricate process. In vitro experiments showcased the remarkable anti-inflammatory and ferroptosis-mitigating effects of an IL-33 antibody in IL-13-induced BEAS-2B cells.
Elucidating Adaptive Compensatory Tigecycline Resistance Mechanisms of RamA, RarA and SoxS in Klebsiella pneumoniae [0.03%]
揭示肺炎克雷伯菌中RamA、RarA和SoxS介导的替加环素适应性耐药机制
Junyang Kuai,Yifan Zhao,Ruobing Wang et al.
Junyang Kuai et al.
Genetic and transcriptomic variations were analyzed using whole-genome and RNA sequencing. Adaptive compensatory mechanisms of RamA, RarA, and SoxS in tigecycline resistance of K. pneumoniae were investigated.
Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma [0.03%]
原发性和转移性食管腺癌不同临床阶段的细胞状态及相邻细胞簇
Josephine Yates,Camille Mathey-Andrews,Jihye Park et al.
Josephine Yates et al.
To decipher EAC disease progression and therapeutic response, we perform multiomic analyses of a cohort of primary and metastatic EAC tumors, incorporating single-nuclei transcriptomic and chromatin accessibility sequencing along with spatial profiling.
Integrated genomic, transcriptomic, and metabolomic analyses provide novel insights into high cadmium accumulation in Phytolacca icosandra L [0.03%]
集成基因组、转录组和代谢组分析为Phytolacca icosandra L.的高镉积累提供了新的见解
Xiong Li,Tao Jin,Yanxia Jia et al.
Xiong Li et al.
The evolutionary features and molecular basis of the conserved abilities of Phytolacca species to accumulate cadmium (Cd) and manganese (Mn) are poorly understood. In this study, the chromosomal-level genome of P. icosandra (2n = 2x = 36) w...
Uncovering PD-L1 among immune cell predictive biomarkers and actionable genetic alterations in anal squamous-cell carcinomas in the era of immunotherapy [0.03%]
免疫治疗时代的肛门鳞状细胞癌免疫细胞预测性生物标志物和可操作的遗传改变中的PD-L1检测
G Sharma,Y Baca,A F Shields et al.
G Sharma et al.
We aimed to analyze the genomic and transcriptomic profiles of ASCC to predict ICI efficacy. Materials and methods: Next-generation sequencing (NGS) of DNA and RNA was carried out.
Reference Vector-guided Evolutionary Algorithm for cluster analysis of single-cell transcriptomes [0.03%]
参考向量引导进化算法在单细胞转录组聚类分析中的应用研究
Fernando M Rodríguez-Bejarano,Miguel A Vega-Rodríguez,Sergio Santander-Jiménez
Fernando M Rodríguez-Bejarano
Background and objective: Single-cell RNA-sequencing (scRNA-seq) has revolutionized transcriptomic studies by providing detailed insights into gene expression profiles at the single-cell level....Clustering is a crucial step in the analysis of scRNA-seq data, since it enables the identification of distinct cell populations based on their transcriptomic profiles and serves as a foundation for downstream analysis.
Integrated transcriptomic, metabolomic, and lipidomic analyses reveal a unique lipid profile of regulatory T cells upon activation [0.03%]
整合转录组、代谢组和脂质组分析揭示激活后调节性T细胞独特的脂质特征
Yohei Sato,Misa Yura,Alana Chandler et al.
Yohei Sato et al.
Regulatory T cells (Tregs) exhibit stable FOXP3 expression and regulate the immune response through suppressive activity. Their unique metabolic properties include increased glycolysis and oxidative phosphorylation. We combined transcriptom...
Network architecture of transcriptomic stress responses in zebrafish embryos [0.03%]
斑马鱼胚胎转录组应激反应的网络架构
Kaylee Beine,Lauric Feugere,Alexander P Turner et al.
Kaylee Beine et al.
Therefore, we examined here whether the transcriptomic response to two environmental stressors (heat, UV, and their combination) is related to PPI architecture in zebrafish (Danio rerio) embryos. We show that stress response genes are situated more centrally in the PPI network....The transcriptomic response to heat was located in both central and peripheral positions, whereas UV response transcripts occupied central to intermediate positions.
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