High-resolution transcriptome atlas of bladder cancer highlights the functional myeloid subsets in modulating immune microenvironment [0.03%]
高分辨率膀胱癌转录图谱揭示功能性髓样亚群在调节免疫微环境中的作用
Jiachen Liu,Zhen Shi,Yajian Li et al.
Jiachen Liu et al.
Background: Despite the recent advancements in characterizing the heterogeneity of the tumour microenvironment (TME), the immunological understanding of myeloid subsets in bladder cancer (BC) remains restricted. A more co...
Sex-specific transcriptome dynamics of Anopheles gambiae during embryonic development [0.03%]
按革氏疟蚊胚胎发育过程中性别特异性的转录组动态变化
Agata Izabela Kalita,Eric Marois,Frank Rühle et al.
Agata Izabela Kalita et al.
Here, we report a comprehensive single-embryo transcriptome atlas of A. gambiae males and females to understand the earliest stages of establishing the sex-specific expression networks.
Single-cell transcriptome atlas of spontaneous dry age-related macular degeneration in macaques [0.03%]
单细胞转录组图谱揭示猴自发干燥年龄相关性黄斑变性
Wenru Su,Yuehan Gao,Xu Jia et al.
Wenru Su et al.
Age-related macular degeneration is the leading cause of irreversible visual impairment in the elderly. It manifests in two forms, wet and dry. However, the mechanisms underlying spontaneous dry age-related macular degeneration (SD-AMD) rem...
A single-cell plume transcriptome atlas of the cold-seep tubeworm Paraescarpia echinospica [0.03%]
日本深海冷泉管栖螠虫Paraescarpia echinospica单细胞羽状触手转录组测序及分析
Yingying Zhang,Xianghui Zhang,Nannan Zhang et al.
Yingying Zhang et al.
Here, we present the single-cell transcriptome atlas of the Paraescarpia echinospica plume, offering single-cell resolution analysis for a deep-sea tubeworm.
A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development [0.03%]
哺乳动物肾脏发育的高分辨率时空转录组图谱
Shan Jiang,Hao Yu,Ting Zhao et al.
Shan Jiang et al.
Here, we present a spatially resolved transcriptome atlas at single-cell resolution to explore the establishment and maintenance of kidney structure in mice. Our analysis reveals 40 migration-related cell-cell communication events during kidney organogenesis.
Genetic effect of the Ph1 locus on transcriptome atlas of anther development-related genes, meiotic chromosome behavior and agronomic traits in bread wheat [0.03%]
Ph1位点的遗传效应及其对小麦小花发育转录谱、减数分裂染色体行为和农艺性状的影响
Rongguang Zhou,Guo Li,Tong Feng et al.
Rongguang Zhou et al.
Proper spatiotemporal expression of meiosis-related genes (MRGs) and other male-microsporogenesis/microgametogenesis-related genes (MMRGs) is crucial for normal anther development, yet their expression patterns remain largely unknown in whe...
Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques [0.03%]
人类动脉粥样硬化斑块中类似三级淋巴器官的单细胞空间转录组学
Zhichao Lai,Deqiang Kong,Qingsong Li et al.
Zhichao Lai et al.
Here we present a spatially resolved single-cell transcriptome atlas of human atherosclerotic plaques, identifying 14 distinct cell types and providing evidence of plaque tertiary lymphoid organs (PTLOs).
Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases [0.03%]
非人灵长类季节性转录组图谱揭示了生理和疾病的季节性变化
Junfeng Chen,Kousuke Okimura,Liang Ren et al.
Junfeng Chen et al.
The metabolic, immune, and endocrine systems show profound seasonal changes in animals, including humans. In addition, morbidity from cardiovascular and psychiatric diseases is more severe and mortality rate is higher in winter. However, th...
A Single-Cell Transcriptome Atlas of Epithelial Subpopulations in HPV-Positive and HPV-Negative Head and Neck Cancers [0.03%]
利用单细胞测序技术绘制HPV阳性和阴性头颈部鳞癌上皮亚群的转录组图谱
Mary C Bedard,Cosette M Rivera-Cruz,Tafadzwa Chihanga et al.
Mary C Bedard et al.
Persistent infection with HPV causes nearly 5% of all cancers worldwide, including cervical and oropharyngeal cancers. Compared to HPV-negative (HPV-) head and neck squamous cell carcinomas (HNSCCs), HPV-positive (HPV+) HNSCCs exhibit a sig...
Cross one single body 49 tissues single-cell transcriptome reveals detailed macrophage heterogeneity during pig pregnancy [0.03%]
猪怀孕期间单个器官49种组织的单细胞转录组揭示巨噬细胞异质性
Xiaoyun Chen,Chenliang Lai,Liping Cai et al.
Xiaoyun Chen et al.
Conclusion: We constructed a multiple-tissue single-cell transcriptome atlas of macrophages in one single healthy pregnant pig, revealing their molecular differences and commonalities across tissues and species.
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