A rare case report: acute necrotizing encephalopathy and acute fulminant myocarditis [0.03%]
罕见病例报告:急性坏死性脑病和急性爆发性心肌炎
Juan Ma,Chenliang Pan,Nan Bai et al.
Juan Ma et al.
Keywords: IL-6; acute fulminant myocarditis; acute necrotizing encephalopathy; shock; tocilizumab (IL-6 inhibitor). © 2025 Ma, Pan, Bai, Zhang, Mi, Wa and Lu.
Clinical characteristics and treatment of infantile Takayasu arteritis in the Chinese Han population: a single-center study [0.03%]
中国汉族婴儿期塔克ayas病的临床特征和治疗:一项单中心研究
Jia Zhu,Min Kang,Yingjie Xu et al.
Jia Zhu et al.
No significant differences were observed between the tocilizumab and infliximab treatment groups. Conclusion: ITA is primarily characterized by fever and hypertension, along with elevated inflammatory biomarkers....Both infliximab and tocilizumab demonstrated effective control of arterial inflammation.
Therapeutic Choices in Systemic Sclerosis-Associated Interstitial Lung Disease, a Survey of 2 International Research Groups [0.03%]
系统性硬化症相关间质性肺病的治疗选择:两项国际合作组的调查结果
Michael Macklin,Iazsmin Bauer Ventura,Dinesh Khanna
Michael Macklin
Mycophenolate mofetil (MMF) has replaced cyclophosphamide (CYC) in most cases of SSc-ILD, with the recent addition of tocilizumab (TCZ) in SSc-ILD as well. Combination immunosuppressive (CI) therapy with rituximab (RTX) and MMF, along with the antifibrotic nintedanib, have also become options.
Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial [0.03%]
糖皮质激素治疗与早期类风湿关节炎患者血浆PCSK9水平升高独立相关:来自随机对照试验的数据
Kristina Lend,Jos Wr Twisk,Nupur Kumar et al.
Kristina Lend et al.
Methods: In this post hoc analysis of the NORD-STAR trial, 296 newly diagnosed patients starting methotrexate with glucocorticoids, certolizumab pegol, abatacept or tocilizumab were included. Serum PCSK9 and LDL-cholesterol levels were measured at baseline and 24 weeks.
Randomized Controlled Trial
RMD open. 2025 Jun 5;11(2):e005129. DOI:10.1136/rmdopen-2024-005129 2025
Efficacy of tocilizumab monotherapy after ultrashort glucocorticoid administration to treat giant cell arteritis: three year follow-up [0.03%]
托珠单抗单药治疗联合超短程糖皮质激素诱导治疗巨细胞动脉炎的疗效:为期三年的随访研究
Lisa Christ,Luca Seitz,Godehard Scholz et al.
Lisa Christ et al.
Objectives: The GUSTO (GCA treatment with Ultra-Short glucocorticoids (GC) and TOcilizumab (TCZ)) trial was set up to evaluate the efficacy and safety of a 52-week TCZ-monotherapy after a 3-day GC-pulse in new-onset GCA. ...
Steroid refractory immune-related acute disseminated encephalomyelitis (ADEM) successfully treated with 2nd and 3rd line immunosuppressive therapy [0.03%]
糖皮质激素治疗抵抗的免疫相关急性播散性脑脊髓炎(ADEM)采用二线和三线免疫抑制剂成功治疗
Cathryn Ann Rees,Aisling Butler,Shree Muthukrishnan et al.
Cathryn Ann Rees et al.
Refractory to the conventional management of IRAEs with corticosteroids, the patient was successfully treated with intravenous immunoglobulins (IVIG), followed by tocilizumab and mycophenolate mofetil (MMF), ultimately resulting in complete radiological resolution of ADEM.
Case Reports
BMJ case reports. 2025 Jun 4;18(6):e263711. DOI:10.1136/bcr-2024-263711 2025
[Sequential treatment with siltuximab and tocilizumab for childhood idiopathic multicentric Castleman disease: a case report] [0.03%]
序贯使用西利珠单抗和托珠单抗治疗儿童难治性多中心型Castleman病1例报告
Ping Yi,Xing-Xing Zhang,Tian Tang et al.
Ping Yi et al.
Therefore, once a child is diagnosed with idiopathic multicentric Castleman disease -TAFRO syndrome, early use of siltuximab should be considered for rapid disease control, followed by tocilizumab for maintenance therapy.
Tocilizumab-Based Treatment of Microvascular Inflammation in Kidney Transplant Recipients: A Retrospective Study [0.03%]
托珠单抗治疗肾移植受者的微血管炎症:一项回顾性研究
Johan Noble,Giorgia Comai,Valeria Corredetti et al.
Johan Noble et al.
Chronic-active antibody mediated rejection (caAMR) is the leading causes of long-term kidney graft failure. Tocilizumab (TCZ), an anti-IL-6 receptor antibody, has been suggested as a treatment, but data are conflicting. We retrospectively s...
The first nationwide epidemiological survey of chronic recurrent multifocal osteomyelitis in Japan [0.03%]
日本全国首次慢性复发性多灶性骨髓炎流行病学调查
Yukako Maeda,Eitaro Hiejima,Kazushi Izawa et al.
Yukako Maeda et al.
Cases that responded to tocilizumab and canakinumab were also reported. Earlier diagnosis was associated with higher rates of symptom- or drug-free status at the last follow-up visit.
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