A Priyadharshini,T M Vijayakumar,N Damodharan et al. A Priyadharshini et al.

The Vivid™ CYP2C19 Blue Screening Kit was utilized, and fluorescence intensity was measured after incubation with PPIs, using ticlopidine as a positive inhibitor control.

Xiao Feng,Junyong Du,Tong Qu et al. Xiao Feng et al.

The NMA demonstrated that Cilostazol showed the best efficacy in preventing MACEs (surface under the cumulative ranking curve (SUCRA): 90.0%). cilostazol significantly reduced the incidence of MACEs compared to aspirin (OR, 0.66; 95% CI, 0.49-0.89), ticlopidine (OR, 0.65; 95% CI, 0.43-1.00), dipyridamole

Linlin Hao,Songhong Wang,Lian Zhang et al. Linlin Hao et al.

Drug predictions targeting P2RY12 suggested prasugrel, ticagrelor, and ticlopidine as potential options owing to their high binding affinity with this key genes.

Yanni Ma,Xintong Yao,Yunding Zou et al. Yanni Ma et al.

Hepatic ischemia-reperfusion injury (IRI) is a major cause of liver damage during hepatic resection, transplantation, and other surgical procedures, often leading to graft failure and liver dysfunction. Recent studies have identified ferrop...

Yusuke Akagi,Hiroyuki Yamakoshi,Yoshiharu Iwabuchi Yusuke Akagi

The highly sensitive mass spectrometric detection of an unprecedented adduct of the ticlopidine metabolite was realized.

Selvi C Ersoy,Richard A Proctor,Warren E Rose et al. Selvi C Ersoy et al.

Herein, we further investigated the impacts of NaHCO3 exposure on CFX susceptibility in the presence and absence of a WTA synthesis inhibitor, ticlopidine (TCP), in a collection of clinical MRSA isolates from skin and soft tissue infections (SSTI) and bloodstream infections (BSI).

Takaaki Suzuki,Mari Iwata,Mika Maezawa et al. Takaaki Suzuki et al.

Monthly personal income in each prefecture were negatively correlated with outpatient out-of-hospital and outpatient in-hospital prescriptions of the PAIs clopidogrel (75 mg), cilostazol (50 mg), cilostazol (100 mg), and ticlopidine (100 mg), but not between monthly personal income and outpatient out-of-hospital...prescription of ticlopidine (100 mg)....For outpatient out-of-hospital prescriptions and outpatient in-hospital prescriptions, negative correlation was generally observed between the usage rate of generic drug and monthly personal income, except for ticlopidine (100 mg), which has the lowest price among the brand-name drugs.

Rong Xu,Pengxiang Xu,Haiyan Wei et al. Rong Xu et al.

Previously, a few studies have shown that ticlopidine can induce liver injury, but the exact mechanism of hepatotoxicity remains unclear....In this study, in order to deeply explore the potential molecular mechanisms of ticlopidine -induced hepatotoxicity, we used zebrafish as a model organism to comprehensively evaluate the hepatotoxicity of ticlopidine and its associated mechanism....Three days post-fertilization, zebrafish larvae were exposed to varying concentrations (1.5, 1.75 and 2 μg/mL) of ticlopidine for 72 h, in contrast, adult zebrafish were exposed exposure to 4 μg/mL of ticlopidine for 28 days....In conclusion, ticlopidine might inhibit normal development and liver proliferation in zebrafish by upregulation of oxidative stress levels, thus leading to embryonic developmental toxicity and hepatotoxicity....In this study, we used zebrafish as a model organism to elucidate the developmental toxicity and hepatotoxicity induced by ticlopidine upregulation of oxidative stress signaling pathway in zebrafish, providing a theoretical basis for clinical application.

Yiwei Zhang,Zhengwei Duan,Yonghao Guan et al. Yiwei Zhang et al.

In addition, niclosamide, ciclopirox, and ticlopidine were found to be potentially useful for the treatment of OA patients infected with SARS-CoV-2.

Chunyang Bi,Laura Schäkel,Salahuddin Mirza et al. Chunyang Bi et al.

In the present study, we performed an extensive structure-activity relationship (SAR) analysis of ticlopidine derivatives and analogs as CD39 inhibitors followed by an in-depth characterization of selected compounds.