Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities [0.03%]
髓鞘功能障碍在衰老和脑疾病中的机制及治疗机会
Zhihai Huang,Yulan Zhang,Peibin Zou et al.
Zhihai Huang et al.
Myelin is a multilamellar membrane that surrounds axons in the vertebrate nervous system. Properly functioning myelin is essential for the rapid conduction of nerve impulses, and it metabolically supports axonal integrity. Emerging evidence...
Yusha Wang,Jing Huang,Huan Tong et al.
Yusha Wang et al.
Understanding these interactions offers new therapeutic opportunities for cancer prevention and treatment.
The Role of Tumor Microenvironment and Immune Cell Crosstalk in Triple-Negative Breast Cancer (TNBC): Emerging Therapeutic Opportunities [0.03%]
三阴性乳腺癌（TNBC）中肿瘤微环境及免疫细胞互作的作用和新兴治疗机会
Hussein Sabit,Amro Adel,Mariam M Abdelfattah et al.
Hussein Sabit et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by its lack of estrogen, progesterone, and HER2 receptors, leading to limited treatment options and poor prognosis. This review synthesizes current research on the ...
Platelets in cancer and immunotherapy: functional dynamics and therapeutic opportunities [0.03%]
血小板在癌症和免疫治疗中的功能动态与治疗机会
Changjing Cai,Yiting Liu,Ruohuang Lu et al.
Changjing Cai et al.
Platelets play a critical role in tumor immunity, particularly in promoting cancer progression. Numerous studies suggest that platelets could serve as a novel target for cancer immunotherapy, however, no comprehensive reviews have yet summa...
Targeting endoplasmic reticulum proteostasis in liver fibrosis: From signaling mechanisms to therapeutic opportunities [0.03%]
靶向内质网蛋白质稳态防治肝纤维化：从信号转导机制到治疗策略
Yawei Kong,Zhengyang Chen,Zhentian Nie et al.
Yawei Kong et al.
Liver fibrosis, a progressive consequence of chronic liver disease, is characterized by excessive extracellular matrix (ECM) deposition and persistent inflammation. It poses a substantial global health burden, particularly among individuals...
Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1 [0.03%]
储藏型RNA通过促进hnRNP C和ELAVL1定位于细胞质从而促进RNA病毒的感染
Jorn E Stok,Sander B van der Kooij,Dennis Gravekamp et al.
Jorn E Stok et al.
Together, our findings reveal a proviral function of vtRNAs during SINV and EMCV infection, which presents therapeutic opportunities to fight infectious diseases.
Chunyu Yu,Jie Sun,Jinlong Tong et al.
Chunyu Yu et al.
The inherent reversibility of these epigenetic switches presents novel therapeutic opportunities for targeted cancer intervention.
Molecular Insights into Pleural Mesothelioma: Unveiling Pathogenic Mechanisms and Therapeutic Opportunities [0.03%]
分子视角下的胸膜间皮瘤：揭示致病机制与治疗机会
Teodora Zahiu,Carmen Mihaela Mihu,Bianca A Bosca et al.
Teodora Zahiu et al.
Pleural mesothelioma (PM) is a rare disease, which is going to be a global medical concern in the 21st century, because of its aggressiveness, late diagnosis, and insufficient therapies. This review seeks to enhance the comprehension of med...
Yonghao Feng,Hanyin Zhang,Wei Wu et al.
Yonghao Feng et al.
Significance: Targeting FA protein signaling pathways offers novel therapeutic opportunities for mitigating obesity-related metabolic syndrome.
Setdb2 Regulates Inflammatory Trigger-Induced Trained Immunity of Macrophages Through Two Different Epigenetic Mechanisms [0.03%]
组蛋白H3第20位赖氨酸甲基转移酶Setdb2通过两种表观遗传机制调节炎症刺激诱导的巨噬细胞适应性免疫反应
Timothy Osborne,Anant Jaiswal,Laszlo Halasz et al.
Timothy Osborne et al.
These results reveal a previously unknown bifurcation in the downstream pathways that distinguishes between pathogenic and sterile inflammatory signaling responses associated with the innate immune memory response and may provide potential therapeutic opportunities to target cytokine vs. interferon pathways
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