Simultaneous Stereoinvertive and Stereoselective C(sp3)-C(sp3) Cross-Coupling of Boronic Esters and Allylic Carbonates [0.03%]
硼酸酯与烯丙基碳酸酯的交叉偶联反应以对映选择性合成季碳中心
Hong-Cheng Shen,Ze-Shu Wang,Adam Noble et al.
Hong-Cheng Shen et al.
The method shows broad substrate scope, enabling primary, secondary, and even tertiary boronic esters to be employed, and can be used to prepare any of the four possible stereoisomers of a coupled product with vicinal chiral centers.
Stereoselective Synthesis of Secondary and Tertiary Boronic Esters via Matteson Homologation [0.03%]
立体选择性合成二级和三级硼酸酯的研究——迈特逊同系物化的应用
Markus Tost,Uli Kazmaier
Markus Tost
Homologation with substituted carbenoids followed by reaction with carbon nucleophiles resulted in configurationally inverted products and tertiary boronic esters in a highly stereoselective fashion. This approach significantly expands the potential of the Matteson reaction.
Substrate Plasticity Enables Group-Selective Transmetalation: Catalytic Stereospecific Cross-Couplings of Tertiary Boronic Esters [0.03%]
底物的塑形性实现组特异性转金属化：叔硼酸酯的催化立体选择性交叉偶联反应
Hao Liang,James P Morken
Hao Liang
Activation of enantiomerically enriched tertiary alkylboronic esters with adamantyllithium generated in situ enables stereoretentive boron-to-copper transmetalation. The resulting alkylcopper species can undergo cross-coupling reactions wit...
Enantioselective Construction of Carbocyclic and Heterocyclic Tertiary Boronic Esters by Conjunctive Cross-Coupling Reaction [0.03%]
串联交叉偶联反应构建光学活性碳环和杂环 tertiary 烷基硼酸酯
Xuntong Zhang,Chenpeng Gao,James P Morken
Xuntong Zhang
Synthesis of stereodefined carbocyclic and heterocyclic tertiary boronic esters is accomplished by performing a conjunctive cross-coupling reaction on preformed cyclic boron ate complexes.
Electrochemical Borylation of Alkyl Halides: Fast, Scalable Access to Alkyl Boronic Esters [0.03%]
烷基卤化物的电化学硼化反应：快速制备烷基硼酸酯的新方法
Bingbing Wang,Pan Peng,Wan Ma et al.
Bingbing Wang et al.
This process provides an efficient and practical access to primary, secondary, and tertiary boronic esters at a high current.
Chan-Lam Amination of Secondary and Tertiary Benzylic Boronic Esters [0.03%]
二级和三级苄位硼酸酯的串联反应胺化反应（ Chan- lam 镁交换串联反应）
James D Grayson,Francesca M Dennis,Craig C Robertson et al.
James D Grayson et al.
Both secondary and tertiary boronic esters can be used as coupling partners, with mono-alkylation of the aniline occurring selectively. This is a rare example of a transition-metal-mediated transformation of a tertiary alkylboron reagent.
Enantioselective synthesis of tertiary boronic esters through catalytic asymmetric reversed hydroboration [0.03%]
催化不对称逆向硼化合成叔硼酸酯类化合物
Tao-Tao Gao,Hou-Xiang Lu,Peng-Chao Gao et al.
Tao-Tao Gao et al.
Chiral tertiary boronic esters are important precursors to bioactive compounds and versatile synthetic intermediates to molecules containing quaternary stereocenters....Here we show the catalytic asymmetric synthesis of enantioenriched tertiary boronic esters through hydroboration of β,β-disubstituted α,β-unsaturated amides. The Rh-catalyzed hydroboration occurs with previously unattainable selectivity to provide tertiary boronic esters in high enantioselectivity.
Enantioselective Allylation of Alkenyl Boronates Promotes a 1,2-Metalate Rearrangement with 1,3-Diastereocontrol [0.03%]
enantioselective allylation of alkenyl boronates促进1,2-金属酸重排并控制1,3-非对映异构体比例
Colton R Davis,Irungu K Luvaga,Joseph M Ready
Colton R Davis
The three-component coupling provides tertiary boronic esters that can undergo multiple additional functionalizations. An extension to trisubstituted olefins sets three contiguous stereocenters.
A Protocol for Direct Stereospecific Amination of Primary, Secondary, and Tertiary Alkylboronic Esters [0.03%]
用于 primary、secondary 和 tertiary 仲基硼酸酯直接立体专一性氨化的协议
Emma K Edelstein,Andrea C Grote,Maximilian D Palkowitz et al.
Emma K Edelstein et al.
In addition to being stereospecific, this process also enables the direct amination of tertiary boronic esters in an efficient fashion.
Highly Enantiospecific Borylation for Chiral α-Amino Tertiary Boronic Esters [0.03%]
高对映选择性硼化制备α-氨基三级硼酸酯类手性化合物
Qingqing Qi,Xuena Yang,Xiaoping Fu et al.
Qingqing Qi et al.
This reaction has a broad scope, enabling the synthesis of various α-amino tertiary boronic esters in excellent yields and, importantly, with universally excellent enantiospecificity (>99 % es) and complete retention of configuration.
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