Targeted tau protein degradation: a promising therapeutic approach for tauopathies [0.03%]
靶向tau蛋白降解：Tau病治疗的有希望的方法
Narjes Baazaoui,Mohammad Y Alfaifi,Ali A Shati et al.
Narjes Baazaoui et al.
Tauopathies are a spectrum of diseases characterized by the pathological aggregation of tau proteins. Several therapeutic strategies have been developed to treat or stop the progression of these diseases, but all have failed in clinical tri...
An aggregation-induced emission-active theranostic agent for selectively detecting and intervening pathological Tau protein [0.03%]
一种聚集诱导发光型诊疗剂选择性检测和干预病理Tau蛋白
Jixue Yang,Youwen Deng,Shu Qin et al.
Jixue Yang et al.
The accumulation of Tau aggregates is commonly linked with various neurodegenerative diseases, such as Alzheimer's disease, Pick's disease, and corticobasal degeneration. Notwithstanding substantial investments in the development of clinica...
In-Cell Residue-Resolved NMR of Micromolar α-Synuclein and Tau at 310 K [0.03%]
毫摩尔α-突触核蛋白和tau在310 K下的单分子细胞内残留NMR分辨率
Hélène Chérot,Théophile Pred&#x;homme,Robert Thai et al.
Hélène Chérot et al.
Aggregates of nonglobular proteins are associated with several degenerative disorders, e.g., α-synuclein and tau involved in Parkinson's and Alzheimer's diseases. Do these proteins undergo progressive changes in their conformations and int...
Mild hyperhomocysteinemia alters spatial and recognition memories in male, but not female rats. Are inflammation, blood-brain barrier damage and tau expression sex-specific predictors? [0.03%]
炎症、血脑屏障损伤和tau蛋白表达具有性别特异性预测作用？
Alessandra Schmitt Rieder,Laura Teixeira da Rosa,Gustavo R K Prauchner et al.
Alessandra Schmitt Rieder et al.
Homocysteine (Hcy) is a non-proteic amino acid that participates in the remethylation cycle of methionine. Hcy levels in plasma around 16-30 µmol/L are characteristics of mild hyperhomocysteinemia (HHcy), which is a know risk factor for ne...
Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of Neurodegeneration [0.03%]
单细胞空间转录组揭示Tau病理性聚集小鼠模型中的异质性神经退行性反应
Xuehan Sun,Lidan Wu,Timothy C Orr et al.
Xuehan Sun et al.
Intracellular tau accumulation contributes to neurodegeneration and systemic dysfunction. Although tau primarily aggregates in neurons as neurofibrillary tangles (NFTs), it also affects other cell types through poorly understood mechanisms....
Elevated polyglutamylation and tau phosphorylation levels are associated with cognitive impairment at diagnosis in patients with primary central nervous system lymphoma [0.03%]
原发中枢神经系统淋巴瘤患者诊断时聚谷氨酰胺水平升高和tau蛋白磷酸化水平与认知障碍有关
Yuki Takeshima,Naoki Shinojima,Kenji Fujimoto et al.
Yuki Takeshima et al.
Background: Primary central nervous system lymphoma (PCNSL) often manifests with cognitive impairment or nonspecific symptoms, which can delay diagnosis and worsen prognosis. However, the mechanisms underlying these neuro...
Diabetes-linked metabolic dysfunction relates with distinct tau phosphorylation patterns, neuroinflammation and cognitive impairment in mouse models of Alzheimer's disease [0.03%]
糖尿病代谢异常与阿尔茨海默病小鼠模型中的tau蛋白磷酸化模式、神经炎症和认知障碍相关
Maria Vargas-Soria,Miriam Corraliza-Gomez,Carmen Infante-Garcia et al.
Maria Vargas-Soria et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β plaques and tau neurofibrillary tangles, with tau pathology being closely linked to cognitive decline. Growing evidence suggests that metabolic...
Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid [0.03%]
使用tau蛋白磷酸化和β淀粉样蛋白的体液标志物预测连续淀粉样正电子发射断层扫描结果
Niklas Mattsson-Carlgren,Linda Karlsson,Weizhong Tang et al.
Niklas Mattsson-Carlgren et al.
Brain amyloid-β (Aβ) pathology is a core feature of Alzheimer disease (AD) and can be quantified using positron emission tomography (PET). Cerebrospinal fluid (CSF) and plasma biomarkers detect abnormal Aβ, but it is unclear to what degr...
Plasma Phosphorylated Tau 217 and Amyloid Burden in Older Adults Without Cognitive Impairment: A Meta-Analysis [0.03%]
无认知障碍老年人血浆磷酸化tau217和淀粉样蛋白负荷的元分析研究
Michael Malek-Ahmadi,Savar Sharma,Fawaz Stipho et al.
Michael Malek-Ahmadi et al.
Importance: Blood-based biomarkers (BBMs) demonstrate high accuracy in detecting Alzheimer disease (AD) pathological changes in symptomatic individuals. In autosomal dominant AD and in individuals with Down syndrome, both...
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