Risankizumab differentially modulates circulating T-cell populations in psoriasis according to autoreactivity status [0.03%]
根据自身反应性状态，risankizumab对银屑病患者循环T细胞群的差异化调节作用
Rebecca Favaro,Paola Facheris,Alessandra Formai et al.
Rebecca Favaro et al.
Background: In a recent paper, our group described that the presence of double autoreactivity to both LL37 and ADAMTSL5 autoantigens in psoriatic patients decreased the clinical responses to risankizumab, but how this inf...
64Cu-labeled Nanobodies Monitor CD4+ T-Cell Populations in Response to Immunotherapy Using PET Imaging [0.03%]
基于PET成像的放射性64Cu标记纳米抗体监测免疫治疗后CD4⁺T细胞动态变化
Laiba Akhtar,Wesley J Hannafon,Lacey R McNally
Laiba Akhtar
Differential Infiltration of T-Cell Populations in Tumor and Liver Tissues Predicts Recurrence-Free Survival in Surgically Resected Hepatocellular Carcinoma [0.03%]
肿瘤和肝脏组织中T细胞浸润差异预测肝癌手术切除后无复发生存率
Eun Ji Jang,Ho Joong Choi,Young Kyoung You et al.
Eun Ji Jang et al.
Background/Objectives: Liver and tumor-infiltrating T cells in hepatocellular carcinoma (HCC) are heterogeneous, comprising the CD69+ tissue-resident T-cell and the CD69- circulating T-cell populations. However, the impact of these distinct...
B-Cell and T-Cell Populations in Peripheral Blood Linked to Ocrelizumab Treatment Efficacy in Multiple Sclerosis [0.03%]
与多发性硬化症奥克雷珠单抗治疗效果有关的外周血B细胞和T细胞群
Akbayir Ece,Kizilay Tugce,Erol Ruziye et al.
Akbayir Ece et al.
Background/aim: Ocrelizumab, a CD20-targeting monoclonal antibody, is used for treatment of multiple sclerosis. The aim of this study was to explore the utility of peripheral blood cell subsets in prediction of treatment ...
Clustering Algorithm-Driven Detection of TRBC1-Restricted Clonal T-Cell Populations Produces Better Results than Manual Gating Analysis [0.03%]
基于聚类算法的TRBC1限制性克隆T细胞群体检测优于手动门控分析
Simon Buček,Andreja Brožič,Simona Miceska et al.
Simon Buček et al.
Flow cytometric (FC) immunophenotyping and T-cell receptor (TCR) gene rearrangement studies are essential ancillary methods for the characterisation of T-cell lymphomas. Traditional manual gating and polymerase chain reaction (PCR)-based an...
Differential Infiltration of Key Immune T-Cell Populations Across Malignancies Varying by Immunogenic Potential and the Likelihood of Response to Immunotherapy [0.03%]
不同免疫原性的癌症中关键T细胞浸润的差异及对免疫治疗反应的可能性不同
Islam Eljilany,Sam Coleman,Aik Choon Tan et al.
Islam Eljilany et al.
Background: Solid tumors vary by the immunogenic potential of the tumor microenvironment (TME) and the likelihood of response to immunotherapy. The emerging literature has identified key immune cell populations that significantly impact imm...
Observational Study
Cells. 2024 Dec 3;13(23):1993. DOI:10.3390/cells13231993 2024
Identification of clonally expanded γδ T-cell populations during CAR-T cell therapy [0.03%]
嵌合抗原受体T细胞治疗过程中γδT细胞克隆的识别扩增
Arman Safavi,Jerome Samir,Mandeep Singh et al.
Arman Safavi et al.
Anti-CD19 Chimeric Antigen Receptor (CAR)-T cell therapies have shown promise for treating B cell malignancies, but the clinical outcome is influenced by both the CAR-T product and the patient's immune system. The role of γδ T cells in th...
Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix [0.03%]
通过改变T细胞外基质的流变学性质来生成功能不同的T细胞群
Kwasi Adu-Berchie,Yutong Liu,David K Y Zhang et al.
Kwasi Adu-Berchie et al.
The efficacy of adoptive T-cell therapies largely depends on the generation of T-cell populations that provide rapid effector function and long-term protective immunity. Yet it is becoming clearer that the phenotypes and functions of T cell...
TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer [0.03%]
TIGIT表达界定了具有不同功能和预后影响的胰腺癌T细胞群体
Max Heiduk,Anna Klimova,Charlotte Reiche et al.
Max Heiduk et al.
Purpose: Immunotherapy has led to a fundamental shift in the treatment of several cancers. However, its efficacy in pancreatic ductal adenocarcinoma (PDAC) is limited. Understanding the expression of inhibitory immune che...
June-Young Koh,Dong-Uk Kim,Bae-Hyeon Moon et al.
June-Young Koh et al.
CD8+ T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through these different processes of Ag...
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