Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration [0.03%]
Ying Jiang,Kuldeep Sachdeva,Chris N Goulbourne et al.
Ying Jiang et al.
Endosomal system dysfunction within neurons is a prominent early feature of Alzheimer's disease (AD) pathology. Multiple AD risk factors are regulators of endocytosis and are known to cause hyper-activity of the early-endosome small GTPase ...
Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease [0.03%]
印度ewithania somnifera和虫草真菌的药用价值：治疗阿尔茨海默病的神经保护特性（临床前证据）
Gabriele Tancreda,Silvia Ravera,Isabella Panfoli
Gabriele Tancreda
Recognized AD pathological hallmarks include amyloid beta plaque and neurofibrillary tangle formation, synaptic dysfunction with considerable apoptosis of cholinergic and dopaminergic neurons, and high levels of oxidative stress and neuroinflammation.
The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Review [0.03%]
长新冠的认知功能障碍的分子机制：叙述性综述
Elena Popa,Andrei Emilian Popa,Mihaela Poroch et al.
Elena Popa et al.
Microglial activation and cytokine release (e.g., IL-6, TNF-α) promote synaptic dysfunction and neuronal injury, while activation of inflammasomes such as NLRP3 amplifies CNS inflammation.
Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain [0.03%]
染色质可及性空间图谱揭示了阿尔茨海默病小鼠大脑中胶质细胞的改变
Dehui Kong,Hongjie He,Joseph Lechner et al.
Dehui Kong et al.
These alterations were associated with AD-related pathways, including neuroinflammation and immune dysregulation, and synaptic dysfunction and neuronal signaling in microglia, as well as lysosomal and proteasomal activity, lipoprotein metabolism, and mitochondrial dysfunction in astrocytes.
Progress of p53 Involvement in Central Nervous System Diseases and Targeted Drug Discovery [0.03%]
p53在中枢神经系统疾病中作用的研究进展及靶向药物发现
Fenglian Xu,Zijun Liu,Ziyu Wang et al.
Fenglian Xu et al.
Recent studies have shown that p53 regulates pathological processes such as apoptosis, ferroptosis, neuroinflammation, mitochondrial dysfunction, DNA damage, and synaptic dysfunction through complex molecular pathways.
Treatment-resistant patients with focal epilepsy of unknown cause display reduced neurogranin levels: a preliminary study [0.03%]
难治性局灶性癫痫患者神经粒素水平降低：一项初步研究
Şişman Büşra Aysel,Savaş Merve,Koral Gizem et al.
Şişman Büşra Aysel et al.
Background and purpose: The role of synaptic dysfunction in focal epilepsy of unknown cause is not well understood.
Rare Copy Number Variants Reveal Critical Cell Types and Periods of Brain Development in Neurodevelopmental Disorders [0.03%]
罕见拷贝数变异揭示神经发育障碍中大脑发育的关键细胞类型和时期
Susmita Malwade,Carl M Sellgren,Navneet A Vasistha et al.
Susmita Malwade et al.
Group A CNVs were associated with synaptic signaling, suggesting that synaptic dysfunction observed in NDDs may originate very early during fetal brain development. Group B CNVs were related to cell cycle and suggest dysfunction in proliferation and differentiation of precursor cells.
Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer's disease cohort [0.03%]
在高风险的阿尔茨海默病队列中，突触标志物与淀粉样蛋白负担调整后的认知衰退有关
Elizabeth M Planalp,Rebecca E Langhough,Erin M Jonaitis et al.
Elizabeth M Planalp et al.
Moreover, a SNAP-25/NPTX2 ratio of synaptic dysfunction explained more variance in cognitive decline than other biomarkers alone.
Nadine Alshakhshir,Lucy He,Liqin Zhao
Nadine Alshakhshir
We hypothesize that these molecular changes can be a shared mechanistic contributor to synaptic dysfunction in AD and diabetes.
Repetitive transcranial magnetic stimulation increases synaptic plasticity of cortical axons in the APP/PS1 amyloidosis mouse model [0.03%]
重复经颅磁刺激增加APP / PS1淀粉样病变小鼠模型皮层轴突的突触可塑性
Barbora Fulopova,William Bennett,Alison J Canty
Barbora Fulopova
Aim: As synaptic dysfunction is one of the key mechanisms associated with cognitive deficits in dementia, we investigated the effect of rTMS on cortical synapses using an APP/PS1 amyloidosis mouse model of AD crossed with fluorescent reporters linked to the Thy-1 promoter.
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