Ozlem Akman,Filiz Onat
Ozlem Akman
Concurrently, advances in electrophysiology and neuroimaging are refining our understanding of the signaling mechanisms that drive AS generation.
Kun Wang,Jiajia Zhao,Yanqiu Wang et al.
Kun Wang et al.
Future studies leveraging multi-omics approaches are needed to elucidate cross-organ signaling mechanisms and identify therapeutic targets to mimic exercise-induced benefits.
Updated insights on ASK1 signaling: mechanisms, regulation, and therapeutic potential in diseases [0.03%]
ASK1信号转导更新机制、调控及其在疾病治疗中的潜力
Divyanshi Thakur,Aniket Nandi,Yash Kumar Gaur et al.
Divyanshi Thakur et al.
Apoptosis signal-regulating kinase 1 (ASK1) is a serine-threonine kinase, that is a member of the mitogen-activated protein kinase kinase (MAP3K) family, which is expressed or incorporated in nucleated cells which leads to the activation of...
Targeting endoplasmic reticulum proteostasis in liver fibrosis: From signaling mechanisms to therapeutic opportunities [0.03%]
靶向内质网蛋白质稳态防治肝纤维化：从信号转导机制到治疗策略
Yawei Kong,Zhengyang Chen,Zhentian Nie et al.
Yawei Kong et al.
Liver fibrosis, a progressive consequence of chronic liver disease, is characterized by excessive extracellular matrix (ECM) deposition and persistent inflammation. It poses a substantial global health burden, particularly among individuals...
Select Early Growth Response (Egr) isoforms augment Hypoxia Inducible Factor 2 (HIF-2) regulation of erythropoietin (Epo) gene expression in mammals [0.03%]
选择性早期生长反应(Egr)异构子增强哺乳动物中低氧诱导因子2(HIF-2)对促红细胞生成素(Epo)基因表达的调节作用
Jason S Nagati,Elhadji M Dioum,Catarina S Giardinetto et al.
Jason S Nagati et al.
These results provide insights into HIF-2 selective signaling mechanisms with ramifications that extend well beyond Epo regulation.
Avilash Singh Yadav,Sridevi Sureshkumar,Alok Krishna Sinha et al.
Avilash Singh Yadav et al.
This model integrates current knowledge and distinguishes thermosensing from other conventional sensing and signaling mechanisms in plants.
Computational exploration of Arabidopsis thaliana N-Myc downregulated-like-1 for protein-protein interaction and phylogenetic conservation [0.03%]
拟南芥N-Myc下调样基因1的蛋白质相互作用和系谱保守性的计算研究
Abhishek Kanojia,Asani Bhaduri,Soumya Nayak et al.
Abhishek Kanojia et al.
NDLs are interacting partners of G-protein subunits which are involved in abiotic and biotic stress signaling mechanisms in plants. Three NDLs (NDL1, NDL2, and NDL3) have been identified in Arabidopsis thaliana.
Liankui Zhou,Ying Liu
Liankui Zhou
We focus on the germline-to-soma intertissue signaling mechanisms recently identified in C. elegans, which modulate systemic physiological responses during reproduction.
Advances in the molecular signaling mechanisms of VEGF/VEGFR2 in fundus neovascularization disease (Review) [0.03%]
血管内皮生长因子及其受体信号转导机制在视网膜新生血管疾病中研究进展（英文）
Huan Shen Li,Xiong Gao Huang
Huan Shen Li
Although the role of VEGF and its receptor in angiogenesis is well documented, research on its major molecular signaling mechanisms is limited....In the present review, a basic overview of the VEGF and VEGFR2 pathways, including their downstream signaling mechanisms and the latest therapeutic advances in the context of fundus neovascularization disease, is provided, and the limitations and future perspectives of current anti-VEGF therapies are...Overall, the purpose of the current review is to provide information on the molecular signaling mechanisms associated with VEGF and VEGFR2 and to perform an in-depth examination of these molecular signaling pathways and their interaction mechanisms.
mTORC1 and STAT3 signaling are indispensable for in vitro TGFβ1-dependent three-dimensional (3D) tendon constructs [0.03%]
mTORC1和STAT3信号传导对体外TGFβ1依赖的三维(3D)腱结构的构建是必不可少的
Bon-Hyeock Koo,Aiden Smith,Kyu Sang Joeng
Bon-Hyeock Koo
We previously demonstrated its pivotal role in in vitro 3D tendon constructs formation; however, the downstream signaling mechanisms remain elusive.
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