Xuebing Xu,Xuming Wu,Dandan Jin et al.
Xuebing Xu et al.
Lactylation has been proved to play an important regulatory role in a variety of diseases, including tumors, metabolic disorders, cardiovascular diseases, and neurodegenerative diseases.
Decoding meningioma prognosis with multi-omics: macrophage diversity, immune-CNV interplay, and novel SPP1-targeted strategies [0.03%]
Hailang Fan,Xiaojie Li,Yaqian Zhao et al.
Hailang Fan et al.
Type-specific CNV profiles showed chromosome 22 deletions relating to immune infiltration, and SPP1-centered gene networks highlighted its regulatory role in macrophage plasticity.
SIRT3 regulates CPT1a acetylation and fatty acid oxidation in renal tubular epithelial cells under diabetic condition [0.03%]
Shuqing Yang,Xingyue Wang,Yu Zhang et al.
Shuqing Yang et al.
In this study, we aimed to investigate the regulatory role of SIRT3 in CPT1a and its protective role against tubular injury in mice with diabetic kidney disease.
Klotho Regulates the Extracellular Matrix Metabolism via TGF-β1/Wnt Signaling Pathway of Fibroblasts in Pelvic Organ Prolapse [0.03%]
Zexuan Zhou,Meixian Fang,Jiashou Luo et al.
Zexuan Zhou et al.
This study aimed to investigate the regulatory role and potential molecular mechanism of Klotho in the pathological process of POP.
FimC binds to the promoter region of agn43 to modulate autoaggregation [0.03%]
FimC通过结合agn43的启动子区域来调控自聚集反应
Zhihao Wang,Xiangpeng Niu,Ningyuan Zhong et al.
Zhihao Wang et al.
However, its regulatory role in agn43-mediated autoaggregation remains unclear.
Unraveling the Role of N6-Methylation Modification: From Bone Biology to Osteoporosis [0.03%]
揭秘N6-甲基化修饰：从骨生物学至骨质疏松症
Junyi Liu,Xiang Chen,Xijie Yu
Junyi Liu
Furthermore, we summarize the regulatory role of m6A modification in various biological processes in osteoblasts, osteoclasts and osteocytes, focusing on its potential signaling pathways in osteoblast and osteoclast differentiation.
Liposomal Nanoparticle Delivery of Ginkgo Flavone Glycosides Enhances SIRT1 Activation and Improves Diabetic Cardiomyopathy [0.03%]
载银杏黄酮苷脂质体纳米粒子通过增强SIRT1激活来改善糖尿病心肌病
Wei Gao,Ruoran Chen,Huixin Tong et al.
Wei Gao et al.
Proteomic sequencing further validated the regulatory role of the SIRT1/FOSL1/TSPAN4 signaling pathway in DCM and suggested that GFGs might enhance energy metabolism and autophagy in diabetic hearts by activating SIRT1.
Pan-cancer analysis of TMED2: unraveling potential immune characteristics and prognostic value in cancer therapy [0.03%]
TMED2的泛癌症分析：揭示其在癌症治疗中的潜在免疫特征和预后价值
Zhuangzhi Wang,Changning Sun,Pengfei Wang et al.
Zhuangzhi Wang et al.
Recent research has identified a close association between TMED2 and tumorigenesis, yet its regulatory role and underlying mechanisms in pan-cancer signaling pathways remain unexplored.
Study on the pathogenesis of idiopathic pediatric acute pancreatitis by combining intestinal microbiome and metabolome [0.03%]
结合肠道微生物组和代谢组研究儿童特发性急性胰腺炎发病机制
Feng Liu,Ying Sun,Jizhong Wang et al.
Feng Liu et al.
SCFAs metabolome analysis indicated that acetic acid, as a key intermediate metabolite, may play a regulatory role in the pathogenesis of IPAP.
Mechanistic and Therapeutic Insights Into the Function of Netrin1 in the Joint Tissue of Osteoarthritis [0.03%]
Netrin1在骨关节炎软骨组织中功能的机制和治疗学见解
Yuzhe Guan,Huifei Tian,Qian Chen et al.
Yuzhe Guan et al.
The Netrin family, part of the laminin superfamily, includes various subtypes, with Netrin1 being notably researched for its regulatory role in bone tissue.Netrin1 protein can activate downstream signaling pathways that affect cell function and regulate the functional activity of various cells in joint
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