Studying the Effect of Receptors Clustering on Hyaluronic Acid Binding with CD44 and the Cell Entry of Hyaluronic Acid Targeting Nanodrugs at Single Molecule/Particle Level [0.03%]
单分子/颗粒水平研究透明质酸受体聚集对细胞外基质糖胺聚糖透明质酸与受体CD44结合及透明质酸靶向纳米药物细胞摄取的影响
Xuening Li,Zhuang Zhang,Siying Li et al.
Xuening Li et al.
Receptor-ligand interactions on cell membrane play key roles in many physiological and pathological processes, especially in the nanodrug targeted delivery system. Hyaluronic acid (HA) is the main ligand for binding CD44 to modulate the tar...
SRSF6 and SRSF1 coordinately enhance the inclusion of human MUSK exon 10 to generate a Wnt-sensitive MuSK isoform [0.03%]
SRSF6和SRSF1协同增强人类MUSK第10号外显子的包含，以生成Wnt敏感型MuSK亚型
Farhana Nasrin,Preeti Nagar,Md Rafikul Islam et al.
Farhana Nasrin et al.
MUSK exon 10 encodes an important part of the frizzled-like cysteine-rich domain, which is necessary for Wnt-mediated acetylcholine receptors clustering at NMJ. MUSK exon 10 is alternatively spliced in humans but not in mice.
Cerebellar dysfunction in the mdx mouse model of Duchenne muscular dystrophy: An electrophysiological and behavioural study [0.03%]
Duchenne肌营养不良小鼠mdx模型小脑功能障碍的电生理和行为学研究
Cynthia Prigogine,Javier Marquez Ruiz,Ana Maria Cebolla et al.
Cynthia Prigogine et al.
Dystrophin has recently been involved in GABAA receptors clustering at postsynaptic densities, and its absence, by disrupting this clustering, leads to decreased inhibitory input to PC.
Urate crystals directly activate the T-cell receptor complex and induce T-cell proliferation [0.03%]
尿酸盐结晶可直接激活T细胞受体复合物并诱导T细胞增殖
Theodoros Eleftheriadis,Georgios Pissas,Maria Sounidaki et al.
Theodoros Eleftheriadis et al.
In light of the evidence that urate crystals can also activate dendritic cells and macrophages without prior internalization but through sequestration of lipid rafts (and consequently receptors clustering in a non specific manner), the authors evaluated whether such a mechanism is involved in the direct
Agrin mutations lead to a congenital myasthenic syndrome with distal muscle weakness and atrophy [0.03%]
AGRIN突变导致远端肌肉无力和萎缩的先天性肌无力综合征
Sophie Nicole,Amina Chaouch,Torberg Torbergsen et al.
Sophie Nicole et al.
In our patients, we found two missense mutations residing in the N-terminal agrin domain, which reduced acetylcholine receptors clustering activity of agrin in vitro.
Bertrand R Caré,Hédi A Soula
Bertrand R Caré
Conclusions: Changing membrane receptors clustering could be a simple mechanism that allows cells to change and adapt its affinity/sensitivity toward a given stimulus.