Less is more: once vs. multiple radioactive iodine (RAI) therapy in patients with RAI-avid pulmonary micrometastatic differentiated thyroid cancer [0.03%]
减量不减效：分化型甲状腺癌肺部微小转移灶患者的一次与多次¹³₁I治疗
Cong Shi,Di Sun,Yu-Qing Sun et al.
Cong Shi et al.
Purpose: To date, the survival benefits of multiple radioactive iodine therapies (RAIT) in RAI-avid pulmonary micrometastatic differentiated thyroid cancer (DTC) remain debatable....Methods: Patients with RAI-avid pulmonary micrometastatic DTC were included and divided into either o-RAIT or m-RAIT group according to the number of RAIT cycles....Results: A total of 117 patients with RAI-avid pulmonary micrometastatic DTC were retrospectively included, with 38 (32.5%) from o-RAIT and 79 (67.5%) from m-RAIT....Conclusions: In patients with RAI-avid pulmonary micrometastatic DTC, o-RAIT exhibited non-inferior PFS benefits compared with m-RAIT, suggesting the "less is more" management strategy of RAIT towards such patients.
Possibility of SARS-CoV-2 Infection in the Metastatic Microenvironment of Cancer [0.03%]
癌症转移微环境中SARS-CoV-2感染的可能性
Takuma Hayashi,Kenji Sano,Ikuo Konishi
Takuma Hayashi
In the pulmonary micrometastatic niche of patients with ovarian cancer, alveolar epithelial stem-like cells were found adjacent to ovarian cancer. Moreover, angiotensin-converting enzyme 2, a host-side receptor for SARS-CoV-2, was expressed in these alveolar epithelial stem-like cells.
Tissue factor-specific ultra-bright SERRS nanostars for Raman detection of pulmonary micrometastases [0.03%]
组织因子特异性的超亮SERRS纳米星用于肺微转移的拉曼检测
Tapas R Nayak,Chrysafis Andreou,Anton Oseledchyk et al.
Tapas R Nayak et al.
Successful detection and delineation of pulmonary micrometastatic lesions as small as 200 μm, corroborated by histology, immunohistochemistry, and bioluminescence imaging confirmed the suitability of both TF as a target and αTF-SERRS-NPs as an effective contrast agent for imaging breast cancer lung metastases
TGF-β upregulates miR-181a expression to promote breast cancer metastasis [0.03%]
TGF-β通过上调miR-181a表达促进乳腺癌转移
Molly A Taylor,Khalid Sossey-Alaoui,Cheryl L Thompson et al.
Molly A Taylor et al.
Along these lines, miR-181a expression was essential in driving pulmonary micrometastatic outgrowth and enhancing the lethality of late-stage mammary tumors in mice.
Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma [0.03%]
染料木素抑制人类肝细胞癌转移的作用
Yan Gu,Cheng-Fang Zhu,Ya-Lei Dai et al.
Yan Gu et al.
The number of pulmonary micrometastatic foci in the genistein group was significantly lower compared with the control group (12.3 +/- 1.8 vs 16.6 +/- 2.6, P < 0.05).
D G Hong,Y L Cho,Il S Park et al.
D G Hong et al.
We collected and compared data between the pulmonary micrometastatic and non-metastatic groups based on several factors. The non-parametric, Mann-Whitney, Kaplan-Meier and log-rank tests were used.
Effect of thalidomide on growth and metastasis of canine osteosarcoma cells after xenotransplantation in athymic mice [0.03%]
反宿主小鼠移植犬骨肉瘤细胞的硫利达明疗效研究其生长和转移
James P Farese,Leslie E Fox,Carol J Detrisac et al.
James P Farese et al.
Mean area of the pulmonary micrometastatic foci was determined for mice from each group. Results: Primary tumor size and weight were not significantly different among groups.
Comparative Study
American journal of veterinary research. 2004 May;65(5):659-64. DOI:10.2460/ajvr.2004.65.659 2004
Solid-phase anti-CD3 antibody activation of murine tumor-infiltrating lymphocytes [0.03%]
固相抗CD3抗体活化的小鼠肿瘤浸润淋巴细胞
A F Massaro,D D Schoof,A Rubinstein et al.
A F Massaro et al.
In vivo antitumor activity of TIL was tested by the adoptive transfer of suboptimal doses of TIL plus systemic rIL-2 to mice with pulmonary micrometastatic disease.
Specific immunotherapy of established visceral micrometastases by BCG-tumor cell vaccine alone or as an adjunct to surgery [0.03%]
卡介苗肿瘤细胞疫苗单独或联合手术治疗已经存在的内脏微小转移病灶的特异性免疫疗法
M G Hanna Jr,L C Peters
M G Hanna Jr
Histopathologically it was determined that immunization with these vaccines prevented the progressive growth of pulmonary micrometastatic foci approximately 0.1 mm in diameter.
Comparative Study
Cancer. 1978 Dec;42(6):2613-25. DOI:10.1002/1097-0142(197812)42:63.0.co;2-k 1978