Unravelling VEXAS syndrome: shedding light on a recently recognised medical condition [0.03%]
解开VEXAS综合征之谜：一种新认识的医学状况不容小觑
Syeda Sarah Raza,Abdullah Ahmad Orakzai,Ahmed Salman et al.
Syeda Sarah Raza et al.
Despite advances, the prognosis remains guarded. However, individually tailored approaches and continued research will lead to improved outcomes.
Case Reports
BMJ case reports. 2025 Jun 10;18(6):e263248. DOI:10.1136/bcr-2024-263248 2025
Challenges in managing Stewart-Treves Syndrome: navigating complexities in recurrent lymphangiosarcoma [0.03%]
斯特沃兹综合征的管理挑战：反复出现的淋巴血管肉瘤的复杂性应对
Tanvi Rao,Joseph Thomas,Harshavardhan Kushal Shetty et al.
Tanvi Rao et al.
It is associated with poor prognosis due to its high risk of recurrence and metastasis.
Case Reports
BMJ case reports. 2025 Jun 10;18(6):e264152. DOI:10.1136/bcr-2024-264152 2025
Insights into retinoblastoma pathogenesis: unraveling RB1, N-MYC and miRNA profiles [0.03%]
视网膜母细胞瘤发病机制的见解：揭示RB1、N-MYC和miRNA谱型
Mohammad Faranoush,Fatemeh Khesali,Pooya Faranoush et al.
Mohammad Faranoush et al.
This study analyses gene expression and specific microRNAs (miRNAs) in patients with retinoblastoma to enhance early diagnosis, prognosis and treatment strategies.
Transcriptome-wide gene-age interaction study and multi-omics comprehensive analysis reveals heterogeneous regulation of NLRC4 during aging on HNSCC prognosis and immune microenvironment [0.03%]
转录组基因年龄交互作用研究及多组学综合分析揭示了NLRC4在衰老过程中对头颈部鳞癌预后和免疫微环境的异质性调控
Ziang Xu,Maojie Xue,Yuqing Yang et al.
Ziang Xu et al.
Subsequent transcriptome-wide NLRC4-age-based three-way interaction analysis reflected the broad association among NLRC4, age and ECM-related genes (mainly the collagen family) on the prognosis of HNSCC.
ZLY032 mediated activation of Notch1-Hes1 signaling inhibits cardiomyocyte ferroptosis to protect against myocardial Ischemia-Reperfusion injury in mice [0.03%]
ZLY032介导的Notch1-Hes1信号激活通过抑制心肌细胞铁死亡作用来保护小鼠心脏免受缺血/再灌注损伤
Hao-Dong Li,Dong-Ping Liu,Man-Yu Gong et al.
Hao-Dong Li et al.
Myocardial ischemia/reperfusion (I/R) injury seriously compromises patients' prognosis and survival rates. Accumulating evidence shows that ferroptosis is intricately involved in myocardial I/R injury. The activation of Notch1 exerts a protective effect on the heart.
Response to comment on "Low chronotropic response in post-myocardial infarction exercise test predicts worse prognosis in patients with preserved or mildly reduced left ventricular ejection fraction" [0.03%]
对“心肌梗死后运动试验低心率反应预测左室射血分数保留或轻度降低患者预后较差”的评论的回应
Krzysztof Smarz,Maciej Tysarowski
Krzysztof Smarz
COMMONALITIES BETWEEN FIBROTIC AND INFLAMMATORY MECHANISMS IN PROLIFERATIVE VITREORETINOPATHY AND PROLIFERATIVE DIABETIC RETINOPATHY [0.03%]
增生性玻璃体视网膜病变和增生型糖尿病视网膜病变的纤维化和炎症机制之间的共同点
Anirudh Sreenivas Bk,Sriram Simakurthy,P Mahesh Shanmugam et al.
Anirudh Sreenivas Bk et al.
Lower efficiency and the need for repetitive applications make prognosis very difficult. Moreover, patient-to-patient variability in disease manifestation and lack of a definite biomarker also add to the complexity.
The novel diarylurea derivative HPT-15 for potential treatment of triple-negative breast cancer via dual inhibition of the mTOR and MAPK pathways [0.03%]
一种新型二芳基脲衍生物HPT-15通过抑制mTOR和MAPK途径联合治疗三阴性乳腺癌的潜力研究
Yujie Wang,Huanhuan Wu,Jiale Luo et al.
Yujie Wang et al.
Dysregulation of the mTOR serine/threonine protein kinase has been linked to the pathogenesis and prognosis of triple-negative breast cancer (TNBC). Meanwhile, the MAPK signaling pathway has been implicated in the progression and drug resistance of TNBC.
USP47 enhances NRP1-mediated angiogenesis to promote gastric cancer progression [0.03%]
USP47通过增强NRP1介导的血管生成促进胃癌进展
Wei Chen,Huizhi Wang,Haitao Sun et al.
Wei Chen et al.
The limited prognosis for advanced GC patients underscores the need for new therapeutic strategies targeting key molecules involved in tumor progression.
Recombinant human ADAMTS13 attenuates LPS-induced acute kidney injury and renal microangiopathy in murine advanced liver fibrosis by cleaving vWF [0.03%]
重组人ADAMTS13通过切割vWF减轻小鼠肝纤维化晚期LPS诱导的急性肾损伤和肾微血管病
Hiroyuki Masuda,Kosuke Kaji,Norihisa Nishimura et al.
Hiroyuki Masuda et al.
Hepatorenal syndrome (HRS) has a poor prognosis among the complication of cirrhosis, yet treatment options are limited. Thrombotic microangiopathy with reduced ADAMTS13 activity and vWF accumulation has been reported to play a key role in the pathogenesis of acute kidney injury (AKI) in cirrhosis.
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