Oriane Turrel,Lili Gao,Stephan J Sigrist
Oriane Turrel
The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic regulators, the small G...
Complexins: Ubiquitously Expressed Presynaptic Regulators of SNARE-Mediated Synaptic Vesicle Fusion [0.03%]
复杂蛋白：普遍表达的前突触调节器，调控SNARE介导的囊泡融合作用
Francisco José López-Murcia,Kerstin Reim,Holger Taschenberger
Francisco José López-Murcia
Neurotransmitter release is a spatially and temporally tightly regulated process, which requires assembly and disassembly of SNARE complexes to enable the exocytosis of transmitter-loaded synaptic vesicles (SVs) at presynaptic active zones ...
Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming [0.03%]
presynaptic Rac1通过调节突触小泡的锚定控制突触效力
Christian Keine,Mohammed Al-Yaari,Tamara Radulovic et al.
Christian Keine et al.
Although actin dynamics impact synaptic transmission, how presynaptic regulators of actin signaling cascades control SV release and replenishment remains unresolved. Rac1, a Rho GTPase, regulates actin signaling cascades that control synaptogenesis, neuronal development, and postsynaptic function.
Cornelia Ablinger,Clarissa Eibl,Stefanie M Geisler et al.
Cornelia Ablinger et al.
Taken together, our study identifies both α2δ-4 and Cachd1 as presynaptic regulators of synapse formation, differentiation, and calcium channel functions that can at least partially compensate for the loss of α2δ-1-3.
Vas deferens neuro-effector junction: from kymographic tracings to structural biology principles [0.03%]
输精管神经效应器连接：从运动描记轨迹到结构生物学原理
L Camilo Navarrete,Nelson P Barrera,J Pablo Huidobro-Toro
L Camilo Navarrete
ATP and adenosine (its metabolic byproduct) are powerful presynaptic regulators of co-transmitter actions. In addition, neuropeptide Y, the third member of the sympathetic triad, is an endogenous modulator.
Sabine Herbst,Noa Lipstein,Olaf Jahn et al.
Sabine Herbst et al.
Munc13 proteins are essential presynaptic regulators that mediate synaptic vesicle priming and play a role in the regulation of neuronal short-term synaptic plasticity.
Munc13-like skMLCK variants cannot mimic the unique calmodulin binding mode of Munc13 as evidenced by chemical cross-linking and mass spectrometry [0.03%]
化学交联和质谱分析表明类似skMLCK的变异体无法模仿Munc13独特的钙调蛋白结合模式
Sabine Herbst,Daniel Maucher,Marian Schneider et al.
Sabine Herbst et al.
Among the neuronal binding partners of calmodulin (CaM) are Munc13 proteins as essential presynaptic regulators that play a key role in synaptic vesicle priming and are crucial for presynaptic short-term plasticity.
Cell and receptor type-specific alterations in markers of GABA neurotransmission in the prefrontal cortex of subjects with schizophrenia [0.03%]
精神分裂症患者额皮质伽玛氨基丁酸神经传递标志物的细胞和受体类型特异性改变
David A Lewis,Takanori Hashimoto,Harvey M Morris
David A Lewis
Specifically, using a combination of methods, we found that subjects with schizophrenia exhibited expression deficits in GABA-related transcripts encoding presynaptic regulators of GABA neurotransmission, neuropeptide markers of specific subpopulations of GABA neurons, and certain subunits of the GABA
Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice [0.03%]
α2B-肾上腺素受体缺陷型小鼠胎盘血管生成障碍与可溶性血管内皮生长因子受体1表达上调有关
Verena Muthig,Ralf Gilsbach,Miriam Haubold et al.
Verena Muthig et al.
Alpha2-adrenoceptors are essential presynaptic regulators of norepinephrine release from sympathetic nerves. Previous studies in mice with targeted deletions in the 3 alpha2-adrenoceptor genes have indicated that these receptors are essential for embryonic development.
Comparative Study
Circulation research. 2007 Sep 28;101(7):682-91. DOI:10.1161/CIRCRESAHA.107.151563 2007
Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia [0.03%]
精神分裂症患者背外侧前额叶皮层相关基因表达变化的研究
T Hashimoto,D Arion,T Unger et al.
T Hashimoto et al.
Subjects with schizophrenia exhibited expression deficits in GABA-related transcripts encoding (1) presynaptic regulators of GABA neurotransmission (67 kDa isoform of glutamic acid decarboxylase (GAD(67)) and GABA transporter 1), (2) neuropeptides (somatostatin (SST), neuropeptide Y (NPY) and cholecystokinin
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